Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

RES,

The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1

in-vitro,

Melanoma,

MSTO-211H

IC50 for Res was 17 µM in MSTO-211H cells.

tumCV↓, Apoptosis↑, Sp1/3/4↓, p27↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,

2983-

RES,

Resveratrol Improves Diabetic Retinopathy via Regulating MicroRNA-29b/Specificity Protein 1/Apoptosis Pathway by Enhancing Autophagy

in-vitro,

Nor,

 retinal Müller cells (RMCs)

*Beclin-1↑, *p62↓, *Sp1/3/4↓, *Apoptosis↓,

2984-

RES,

Involvement of miR-539-5p in the inhibition of de novo lipogenesis induced by resveratrol in white adipose tissue

in-vivo,

Nor,

 Male Wistar rats were fed (6 weeks) an obesogenic diet: a control group and a group treated with resveratrol (30 mg kg(-1) d(-1))

*Sp1/3/4↓, *SREBP1↓, *FASN↓,

2985-

RES,

Resveratrol Inhibits Diabetic-Induced Müller Cells Apoptosis through MicroRNA-29b/Specificity Protein 1 Pathway

in-vivo,

Nor,

Retina was obtained from normal and diabetic rats with or without RSV (5 and 10 mg/kg/day)

vitro+vivo,

Diabetic,

*Sp1/3/4↓, *miR-29b↑,

2986-

RES,

Effect of the natural compound trans‑resveratrol on human MCM4 gene transcription

in-vitro,

Cerv,

HeLa

in-vitro,

AML,

HL-60

Sp1/3/4↑,

2987-

RES,

Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1

in-vivo,

Nor,

demonstrated in rat myocardial infarction (MI) model

*VEGF↑, *iNOS↑, *NF-kB↑, *Sp1/3/4↑, *cardioP↑,

2988-

RES,

The Antimetastatic Effects of Resveratrol on Hepatocellular Carcinoma through the Downregulation of a Metastasis-Associated Protease by SP-1 Modulation

in-vitro,

HCC,

HUH7

TumCMig↓, TumCI↓, uPA↓, Sp1/3/4↓,

2991-

RES,

Chemo,

Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells

in-vitro,

Melanoma,

MSTO-211H

in-vitro,

Nor,

MeT5A

eff↑, selectivity↑, Sp1/3/4↓,

101-

RES,

Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis

in-vitro,

GC,

SGC-7901

 10 uM

HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑, TumCI↓, TumMeta↓,

105-

RES,

QC,

The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell

in-vitro,

Pca,

PANC1

 10 uM

 CSCS (CD133-)

N-cadherin↓, TNF-α↓, ACTA2↓, EMT↓, CD133↓, CSCs↓,

104-

RES,

QC,

Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a

in-vitro,

Colon,

HT-29

 18.7 ug/mL

Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,

103-

RES,

CUR,

QC,

The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice

vitro+vivo,

BC,

4T1

 Mice: 24 mg/kg
Res, 24 mg/kg
Cur, 12 mg/kg
Que
Translated into an edible human dose of 738 mg/day (including 295.2 mg Res, 295.2 mg Cur, and 147.6 mg Que)

 8.5mg/L

 mice

ROS↑, MMP↓, Bcl-2↓, BAX↑, Casp9↑, T-Cell↑, TGF-β↓,

102-

RES,

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

in-vitro,

PC,

MIA PaCa-2

HH↓, PTCH1↓, Smo↓, HH↓, EMT↓, PI3K/Akt↓, NF-kB↓, TumCP↓, Apoptosis↑, ChemoSen↑,

1047-

RES,

Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells

in-vitro,

Lung,

H1299

below 5 μM

in-vitro,

Lung,

A549

in-vitro,

Lung,

H460

PD-L1↑, Snail↑, E-cadherin↓, N-cadherin↑, Fibronectin↑, Vim↑, Axin2↓,

967-

RES,

Resveratrol binds and inhibits transcription factor HIF-1α in pancreatic cancer

Analysis,

PC,

silico approach

Hif1a↓,

882-

RES,

Resveratrol: A Double-Edged Sword in Health Benefits

Review,

NA,

AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,

880-

RES,

Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol

in-vitro,

BC,

MDA-MB-231

other↓, TumW↓, FOXO↑, BMP2↑,

881-

RES,

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

PANC1

in-vitro,

Pca,

DU145

TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,

879-

RES,

Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it

in-vitro,

CRC,

HCT116

TumCP↓, NF-kB↓,

924-

RES,

Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells

in-vitro,

OS,

U2OS

in-vitro,

Lung,

A549

TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,

878-

RES,

Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

vitro+vivo,

CRC,

LoVo

12.5uM, 150 mg/Kg

mice

TumMeta↓, E-cadherin↑, Vim↓, TGF-β↓, SMAD2↓, EMT↓, SMAD3↓,

877-

RES,

Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway

in-vitro,

CRC,

LoVo

55uM

in-vitro,

CRC,

HCT116

MALAT1↓, Wnt/(β-catenin)↓, TumCI↓, TumMeta↓,

885-

RES,

Resveratrol induces intracellular Ca2 + rise via T-type Ca2 + channels in a mesothelioma cell line

in-vitro,

RCC,

REN

EC50 = 2.7 μM

in-vitro,

Nor,

MeT5A

EC50 = 4.9 μM

as normal cell model

TumCG↓, Ca+2↑, *toxicity↓,

871-

RES,

CUR,

QC,

The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice

in-vitro,

BC,

4T1

8.55mg/L

 Res:Cur:Que = 1:1:0.5

in-vivo,

BC,

4T1

tumor bearing mice- subcutaneous injection of 4T1 breast cancer cells

T-Cell↑, Neut↓, Macrophages↓, ROS↑, MMP↓, other↓, AntiTum↑, TumVol↓,

884-

RES,

PTS,

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

pterostilbene displayed a 1.97-fold lower IC50 when compared to resveratrol (42.3 µM vs. 83.5 µM

TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,

883-

RES,

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

HDAC↓, TumCCA↑, Apoptosis↑, angioG↓, ROS↑,

993-

RES,

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

in-vitro,

CRC,

Caco-2

10 µM, 48 hr

in-vivo,

Nor,

HCEC 1CT

TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,

4706-

RES,

Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications

Review,

Nor,

*SIRT1↑, *CLOCK↝,

4657-

RES,

Resveratrol, cancer and cancer stem cells: A review on past to future

Review,

Var,

CSCs↓, CD133↓, Shh↓, Twist↓, Snail↓, MMP2↓, MMP9↓, Smad1↓, CD44↓, ALDH1A1↓, OCT4↓, Nanog↓, STAT3↓, survivin↓, cycD1/CCND1↓, COX2↓, cMyc↓,

4669-

RES,

Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis

in-vitro,

Cerv,

RAD51↓, CSCs↓,

4668-

RES,

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

in-vitro,

NPC,

ROS↑, MMP↓, CSCs↓, P53↑, EMT↓,

4667-

RES,

CUR,

SFN,

Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models

Review,

Var,

CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,

4666-

RES,

Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway

in-vitro,

Lung,

H23

in-vitro,

Lung,

H292

in-vitro,

Lung,

A549

CSCs↓, eff↑, Akt↓, GSK‐3β↑, SOX2↓, cMyc↓, TumCCA↑, ROS↑, Apoptosis↑,

4663-

RES,

Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models

Review,

Var,

*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,

4670-

RES,

CUR,

EGCG,

TQ,

Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol

Review,

Nor,

*antiOx↑, *Inflam↓, *AntiAge↑, *SIRT1↑, *SIRT3↑, *FOXO↑, *ROS↓,

4662-

RES,

A Promising Resveratrol Analogue Suppresses CSCs in Non-Small-Cell Lung Cancer via Inhibition of the ErbB2 Signaling Pathway

in-vitro,

NSCLC,

A549

 25 and 50 μM

in-vitro,

NSCLC,

H460

CSCs↓, CD133↓, OCT4↓, β-catenin/ZEB1↓, HER2/EBBR2↓, TumCP↓, PI3K↓, Akt↓, ALDH1A1↓, eff↑,

4289-

RES,

Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells

in-vitro,

AD,

0.1–10 μM

 N2a cells

*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,

4288-

RES,

Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β

in-vivo,

AD,

Rats

*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,

4287-

RES,

Resveratrol targeting tau proteins, amyloid-beta aggregations, and their adverse effects: An updated review

Review,

AD,

*p‑tau↓,

4286-

RES,

Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease

Review,

AD,

*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,

4285-

RES,

Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy

in-vivo,

AD,

PS19 mice

*tau↓, *cognitive↑, *Inflam↓,

4284-

RES,

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex

in-vitro,

AD,

HEK293

NA,

Stroke,

in-vivo,

AD,

Female wild type C57BL/6 mice

*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,

4570-

RF,

Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems

Review,

Nor,

*ETC↓, *ROS↑, *ROS∅,

4357-

RF,

Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies

Review,

Var,

other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,

3729-

RF,

Review of the Evidence that Transcranial Electromagnetic Treatment will be a Safe and Effective Therapeutic Against Alzheimer's Disease

in-vivo,

AD,

pulsed at 918 MHz, 1.05 W/kg SAR

mice

*cognitive↑, *Aβ↓, *ROS↓, *ATP↑,

3730-

RF,

Transcranial electromagnetic treatment against Alzheimer's disease: why it has the potential to trump Alzheimer's disease drug development

Review,

AD,

300-1900 MHz

*cognitive↑, *Aβ↓,

3731-

RF,

Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice

in-vivo,

AD,

(918 MHz; 0.25 w/kg

mice

*cognitive↑, *Aβ↓, *neuroP↑, *memory↑,

3732-

RF,

Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit

in-vivo,

AD,

GSM, pulsed/modulated, 918 MHz, 0.25–1.05 W/kg

mice

*cognitive↑, *Aβ↓,

3733-

RF,

Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit?

in-vivo,

AD,

two 1-h periods daily at 918 MHz, 0.25â
1.05 specific absorption rate (SAR

mice

*Aβ↓, *cognitive↑, *mt-ROS↓, *ATP↑,

3736-

RF,

Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1

in-vivo,

AD,

100 Hz (100 pulses per second) and field strength
was 50 kV/m

healthy Sprague Dawley (SD) rats, EMP pulses were generated by a spark gap pulse

*cognitive↓, *BACE↑,

Showing Research Papers: 4651 to 4700 of 5902
Prev Page 94 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5902

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes ⓘ

AntiTum↑, 3, TumVol↓, 1, TumW↓, 1,
Total Targets: 128

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 5, GSH↑, 2, HO-1↑, 1, lipid-P↓, 1, MDA↓, 1, ROS↓, 4, ROS↑, 1, ROS∅, 1, mt-ROS↓, 1, SIRT3↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 2, ETC↓, 1, PGC-1α↓, 1,

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1, AMPK↑, 3, p‑CREB↑, 1, ECAR∅, 1, FAO↑, 1, FASN↓, 1, SIRT1↑, 4, SREBP1↓, 1,

Cell Death ⓘ

Akt↑, 1, Apoptosis↓, 1, BAX↓, 1, Bcl-2↑, 1, iNOS↓, 1, iNOS↑, 1,

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1, Sp1/3/4↓, 3, Sp1/3/4↑, 1,

Transcription & Epigenetics ⓘ

other?, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1, p62↓, 1,

Proliferation, Differentiation & Cell State ⓘ

CLOCK↝, 1, FOXO↑, 1, GSK‐3β↓, 2, PI3K↑, 1,

Migration ⓘ

AntiAg↑, 1, miR-29b↑, 1, MMP9↓, 1, PKA↑, 1,

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1, IL6↓, 1, Inflam↓, 5, NF-kB↓, 1, NF-kB↑, 1,

Synaptic & Neurotransmission ⓘ

ADAM10↑, 1, BDNF↑, 1, tau↓, 1, p‑tau↓, 5,

Protein Aggregation ⓘ

Aβ↓, 7, BACE↓, 2, BACE↑, 1, NLRP3↓, 1, PP2A↑, 4,

Clinical Biomarkers ⓘ

IL6↓, 1,

Functional Outcomes ⓘ

AntiAge↑, 1, cardioP↑, 1, chemoPv↑, 1, cognitive↓, 1, cognitive↑, 6, memory↑, 4, neuroP↑, 4, toxicity↓, 1,
Total Targets: 65

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Autophagy & Lysosomes ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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