Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3644- Sage,    Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers
- Human, AD, NA
*memory↑, *cognitive↑,
3645- Sage,  RosA,    Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family
- Study, AD, NA
*AChE↓, *AChE↓,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
2040- SAHA,    The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
- in-vitro, Pca, LNCaP - in-vitro, CRC, T24/HTB-9 - in-vitro, BC, MCF-7
HDAC↓, TumCG↓, Diff↑, Apoptosis↑, TXNIP↑,
4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Ferroptosis↑, CSCs↓, NF-kB↓, GSR↓, GSH↑, Iron↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4899- Sal,    Anticancer activity of salinomycin quaternary phosphonium salts
- in-vitro, Var, NA
eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5005- Sal,    Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting
- Review, Var, NA
CSCs↑,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
5002- Sal,  SFN,    Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo
- in-vivo, CRC, Caco-2 - vitro+vivo, CRC, CX-1
Apoptosis↑, PI3K↓, Akt↓, P53↑, BAX↑, Bax:Bcl2↑, p‑PARP↑, TumCMig↓,
5001- Sal,    Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex
- in-vitro, CRC, NA
CSCs↓, β-catenin/ZEB1↓, Wnt↓,
5000- Sal,    Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- vitro+vivo, BC, NA
CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,
4999- Sal,    Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells
- in-vitro, Pca, PC3
Bacteria↓, CSCs↓, ER Stress↑,
4997- Sal,    Salinomycin Treatment Specifically Inhibits Cell Proliferation of Cancer Stem Cells Revealed by Longitudinal Single Cell Tracking in Combination with Fluorescence Microscopy
- in-vitro, BC, NA
CD24↓, TumCP↓, CSCs↓,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,
4994- Sal,  Rad,    Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation
AntiCan↑, RadioS↓, Apoptosis↑, NRF2↓, ROS↑, DNAdam↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, eff↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4907- Sal,    A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents
- Review, Var, NA
Apoptosis↑, MDR1↓, CSCs↓,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
4912- Sal,    Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157
CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP↑, AKT1↓, mTOR↓,
4998- Sal,    Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain
- in-vitro, NPC, NA
CSCs↓,
5128- Sal,    Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
- in-vitro, AML, NA
CSCs↓,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
5126- Sal,    Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
CSCs↓, Ca+2↑, cal2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, MMP↓,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
5123- Sal,    Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells
- in-vitro, BC, MCF-7 - in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HEK293
Wnt↓, β-catenin/ZEB1↓, mTORC1↓, GSK‐3β↑, cycD1/CCND1↓, survivin↓, LRP6↓, TumCG↓, Apoptosis↑,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5121- Sal,    Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, BC, NA
CSCs↓, Wnt↓, selectivity↑,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
3939- SAMe,  VitB12,  ALC,    Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- Trial, NA, NA
*cognitive↑, *Mood↑,
3938- SAMe,    S-adenosyl-L-methionine in the treatment of Alzheimer's disease
- Human, AD, NA
*other↑,
4115- SAMe,    Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
- Review, AD, NA
*Mood↑, *BBB↑,
4114- SAMe,    S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research
- Review, AD, NA
*Mood↑, *BBB↑, *5HT↑, *p‑tau↓, *Aβ↓, *other↑,
1210- SANG,    Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer
- in-vitro, BC, NA
EphB4↓, Hif1a↓, STAT3↓, MAPK↓, ERK↓,
1209- SANG,    Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration
- in-vitro, Lung, A549
VEGF↓, TumCMig↓, Akt↓, p38↓,
1208- SANG,    Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single-stranded DNA-binding protein 1 (SSBP1) promoter region
- in-vitro, OS, NA
SSBP1↑, mtDam↑, Apoptosis↑, JAK↓, STAT3↓, PI3k/Akt/mTOR↓, ROS↑, MMP↓,
1307- SANG,    Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway
- in-vitro, CRC, HT-29
Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑,
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF-7
MMP9↓, COX2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
1134- SANG,    Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
Hif1a↓, EMT↓, Snail↓, PI3K↓, Akt↓, SMAD2↓, SMAD3↓,
3853- SAS,    Sulfur-containing therapeutics in the treatment of Alzheimer's disease
- Review, AD, NA
*antiOx↑,

Showing Research Papers: 4801 to 4850 of 5922
Prev Page 97 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5922

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 2,   Ferroptosis↑, 3,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   GSR↓, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 4,   lipid-P↑, 3,   MDA↑, 1,   NRF2↓, 2,   OXPHOS↓, 3,   ROS↑, 17,   SOD↓, 2,   SOD1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 5,   mitResp↑, 1,   MMP↓, 8,   mtDam↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMPK↑, 1,   cMyc↓, 1,   Glycolysis↓, 1,   LDH↓, 1,   NADPH↓, 1,   PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 14,   Apoptosis∅, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 1,   Casp12↑, 1,   Casp3↑, 5,   Casp9↑, 3,   Cyt‑c↑, 1,   Ferroptosis↑, 3,   JNK↑, 1,   lysoMP↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MOMP↑, 1,   Myc↓, 1,   necrosis↑, 2,   p27↑, 1,   p38↓, 1,   survivin↓, 2,   TumCD↑, 3,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 6,   ERStress↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes ⓘ

autoF↓, 2,   LC3II↑, 1,   lysosome↓, 1,   lysosome↝, 1,   MitoP↑, 1,   TumAuto↓, 1,   TumAuto↑, 7,  

DNA Damage & Repair ⓘ

DNAdam↑, 7,   P53↑, 3,   p‑P53↑, 1,   p‑PARP↑, 1,   cl‑PARP↝, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 5,   P21↑, 3,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 3,   CD24↓, 3,   CD44↓, 3,   CSCs↓, 24,   CSCs↑, 3,   CSCsMark↓, 2,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,   Diff↑, 4,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   LRP6↓, 1,   mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 2,   PTCH1↓, 1,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 3,   TumCG↓, 8,   Wnt↓, 12,  

Migration ⓘ

AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 3,   cal2↑, 1,   E-cadherin↑, 1,   EphB4↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   MMP9↓, 1,   MUC1-C↓, 1,   N-cadherin↓, 1,   PKCδ↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TumCI↓, 2,   TumCMig↓, 4,   TumCP↓, 6,   TumMeta↓, 1,   TXNIP↑, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↑, 1,   Hif1a↓, 3,   VEGF↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CTSZ↓, 1,   JAK↓, 1,   NF-kB↓, 3,   PGE2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ABC↓, 1,   BioAv↓, 1,   ChemoSen↑, 7,   Dose↝, 1,   eff↓, 3,   eff↑, 7,   MDR1↓, 1,   RadioS↓, 1,   RadioS↑, 4,   selectivity↑, 8,   selectivity↝, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ferritin↓, 1,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   toxicity⇅, 1,   toxicity↝, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 162

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 3,   BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   Aβ↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 3,   memory↑, 2,   Mood↑, 3,   neuroP↑, 1,   toxicity↝, 1,  
Total Targets: 17

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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