Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF-7
MMP9↓, COX2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
1134- SANG,    Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
Hif1a↓, EMT↓, Snail↓, PI3K↓, Akt↓, SMAD2↓, SMAD3↓,
3853- SAS,    Sulfur-containing therapeutics in the treatment of Alzheimer's disease
- Review, AD, NA
*antiOx↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT↓, GPx4↓, FTH1↓,
5045- SAS,    Sulfasalazine, a potent cystine-glutamate transporter inhibitor, enhances osteogenic differentiation of canine adipose-derived stem cells
- in-vivo, Var, NA
xCT↓, GSH↓, BMPs↑, Diff↑,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
5043- SAS,    Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
- in-vivo, Nor, NA
*toxicity↝, *xCT↓, toxicity↓,
5042- SAS,    xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- Review, Var, NA
xCT↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,
5041- SAS,  Cisplatin,    Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
- in-vitro, CRC, NA
xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,
5040- SAS,    Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors
- in-vitro, GBM, A172 - in-vitro, Melanoma, A375 - in-vitro, GBM, U87MG - in-vitro, BC, MCF-7
GSH↓, toxicity↓, xCT↓,
5141- SAS,    Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
- in-vitro, CRC, SW-620
NF-kB↓,
5140- SAS,    Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β
- in-vitro, AML, Jurkat - in-vitro, CRC, SW-620
TNF-α↓, IKKα↓, NF-kB↓,
5138- SAS,  Rad,    Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion
- vitro+vivo, GBM, NA
cystine↓, GSH↓, ROS↑, RadioS↑, eff↓, DNAdam↑, OS↑,
5039- SAS,    Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer
- vitro+vivo, BC, NA
xCT↓, ROS↑, GSH↓, Ferroptosis↑, TumCG↓, toxicity↓, lipid-P↑,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,
5037- SAS,    Inhibition of xCT by sulfasalazine alleviates the depression-like behavior of adult male mice subjected to maternal separation stress
- in-vivo, Nor, NA
xCT↓, Mood↑, Inflam↓, glut↓,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, eff↑, TumCG↓,
5035- SAS,    Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use
- Human, GC, NA - in-vitro, GC, NCI-N87 - in-vitro, GC, SGC-7901
other?, TumCP↓, TumMeta↓, TumCI↓, xCT↓, OS↑,
1388- Sco,    Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells
- in-vitro, CRC, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
2536- SDT,    Sonodynamic Therapy: Rapid Progress and New Opportunities for Non-Invasive Tumor Cell Killing with Sound
- Review, Var, NA
ROS↑, eff↑, Dose?,
2551- SDT,    Sonoporation: Past, Present, and Future
- Review, Var, NA
other↝, sonoP↑, Dose↝,
2550- SDT,    Intracellular Delivery and Calcium Transients Generated in Sonoporation Facilitated by Microbubbles
- in-vitro, Nor, NA
*Ca+2↑, sonoP↑, BioEnh↑,
2537- SDT,    Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers
- Review, Var, NA
Dose↝, eff↑, eff↑, eff↑, eff↑,
2548- SDT,    Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature
- Review, Var, NA
sonoP↑, Dose↝, eff↓, Dose↝, BioEnh↑, toxicity↝,
2141- Se,    Selenium and cancer risk: Wide-angled Mendelian randomization analysis
- Review, NA, NA
Dose↝, Risk↝,
2140- Se,    Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression
- Review, Var, NA
Risk↓, antiOx↑, eff↑, eff↝,
2142- Se,    A U-shaped association between selenium intake and cancer risk
- Review, NA, NA
*Risk↝, Dose↝, *Risk↓,
1696- Se,    Selenium dietary intake and survival among CRC patients
- Human, CRC, NA
OS↑,
1695- Se,    Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study
- Trial, CRC, NA
Risk↓, selm↑, Dose↓, antiOx↑, Dose↑, Dose↝,
1689- Se,    Selenium and breast cancer - An update of clinical and epidemiological data
- Analysis, BC, NA
OS↑, eff↑, Dose∅, *toxicity↝, eff↑,
1690- Se,    Selenium and cancer: a story that should not be forgotten-insights from genomics
- Review, Var, NA
Dose↓, other↝,
1691- Se,    The influence of selenium and selenoprotein gene variants on colorectal cancer risk
- Analysis, CRC, NA
Risk↓,
1692- Se,    Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status
- Analysis, CRC, NA
Risk↓,
1693- Se,    Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study
- Analysis, BC, NA
Risk↓, other∅,
1694- Se,    Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer
- Analysis, CRC, NA
AntiCan↑, selenoP↓,
1705- Se,    Serum Selenium Level and 10-Year Survival after Melanoma
- Study, Melanoma, NA
OS↑,
1704- Se,    Prospective study of toenail selenium levels and cancer among women
- Study, Var, NA
Risk∅,
1703- Se,    An Assessment of Serum Selenium Concentration in Women with Endometrial Cancer
- Study, EC, NA
Risk↓, selm↝,
1702- Se,    Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women
- Human, Ovarian, NA
Risk↓, eff∅,
1701- Se,    An Assessment of Serum Selenium Concentration in Women with Ovarian Cancer
- Human, Ovarian, NA
Risk↓, Risk↓, Dose∅,
1700- Se,    Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers
- Review, Var, NA
Dose↝, Risk↑, Dose↝, Risk↓,
1699- Se,    Vegetarianism and colorectal cancer risk in a low-selenium environment: effect modification by selenium status? A possible factor contributing to the null results in British vegetarians
- Analysis, CRC, NA
Dose↑, eff↓, Dose↓,
1698- Se,    Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study
- Human, CRC, NA
Risk↓,
4214- Se,    Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway
- in-vivo, NA, NA
*memory↑, *other↑, *BDNF↑, *TrkB↑,
4751- Se,  Chemo,    Selenium Protects Against Toxicity Induced by Anticancer Drugs and Augments Antitumor Activity: A Highly Selective, New, and Novel Approach for the Treatment of Solid Tumors
- in-vivo, Var, NA
Dose↝, ChemoSen↑, chemoP↑,
4755- Se,  Chemo,    Selenium Prevention of Alopecia, Bladder and Kidney Toxicity Induced by Chemotherapeutic Agents
- in-vitro, Var, NA
chemoP↑, creat↓, BUN↓,
4754- Se,  Chemo,    The effect of selenium yeast in the prevention of adverse reactions related to platinum-based combination therapy in patients with malignant tumors
- Trial, Var, NA
chemoP↑, QoL↑, chemoP↑, Pain↓,
4757- Se,  Chemo,    The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
- Trial, NA, NA
Dose↝, *ALP↓, chemoP↑,

Showing Research Papers: 4851 to 4900 of 5925
Prev Page 98 of 119 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5925

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   cystine↓, 1,   Ferroptosis↑, 3,   GPx4↓, 1,   GSH↓, 11,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 1,   ROS↑, 11,   selenoP↓, 1,   SOD↓, 2,   xCT↓, 11,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,   selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

BUN↓, 1,   glut↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Casp7↑, 2,   Ferroptosis↑, 3,   Myc↓, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↑, 1,   other↝, 2,   other∅, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNArepair↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   Diff↑, 1,   EMT↓, 1,   p‑ERK↓, 1,   PI3K↓, 1,   TumCG↓, 5,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 1,   MMP9↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,   sonoP↑, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL2↓, 1,   Inflam↓, 2,   NF-kB↓, 4,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioEnh↑, 2,   ChemoSen↑, 2,   Dose?, 1,   Dose↓, 3,   Dose↑, 2,   Dose↝, 13,   Dose∅, 2,   eff↓, 6,   eff↑, 12,   eff↝, 2,   eff∅, 1,   Half-Life↝, 1,   RadioS↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

BMPs↑, 1,   creat↓, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 5,   Mood↑, 1,   OS↑, 6,   Pain↓, 1,   QoL↑, 1,   Risk↓, 11,   Risk↑, 1,   Risk↝, 1,   Risk∅, 1,   toxicity↓, 3,   toxicity↝, 1,  
Total Targets: 102

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   xCT↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

Ca+2↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   TrkB↑, 1,  

Clinical Biomarkers ⓘ

ALP↓, 1,  

Functional Outcomes ⓘ

memory↑, 1,   Risk↓, 1,   Risk↝, 1,   toxicity↝, 2,  
Total Targets: 12

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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