| 7610- | I3C, | Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line |
| - | in-vitro, | BC, | MDA-MB-468 | - | in-vitro, | Nor, | HBL-100 | - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 7611- | I3C, | Long-term responses of women to indole-3-carbinol or a high fiber diet |
| - | Trial, | Nor, | NA |
| 7612- | I3C, | Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells |
| - | in-vitro, | Nor, | MCF10 |
| 7587- | I3C, | Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest |
| - | in-vitro, | Cerv, | HeLa |
| 7595- | I3C, | Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans |
| - | Human, | Nor, | NA |
| 7580- | I3C, | Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane |
| - | Trial, | NA, | NA |
| 7581- | I3C, | A phase I study of indole-3-carbinol in women: tolerability and effects |
| - | Trial, | Nor, | NA |
| 7582- | I3C, | Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway |
| - | vitro+vivo, | ESCC, | NA |
| 7583- | I3C, | Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer |
| - | vitro+vivo, | CRC, | NA |
| 7584- | I3C, | Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | CRC, | HCT8 | - | in-vitro, | Liver, | HepG2 |
| 7585- | I3C, | Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells |
| - | in-vitro, | BC, | NA |
| 7586- | I3C, | Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells |
| - | in-vitro, | BC, | NA |
| 7588- | I3C, | Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells |
| - | in-vitro, | AML, | NA |
| 7589- | I3C, | Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells |
| - | vitro+vivo, | Laryn, | HEp2 |
| 7590- | I3C, | Indole-3-carbinol synergistically sensitises ovarian cancer Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatmentcells to bortezomib treatment |
| - | in-vivo, | Ovarian, | NA |
| 7591- | I3C, | Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway |
| - | in-vitro, | NPC, | CNE2 |
| 7592- | I3C, | Indole-3-carbinol as a chemopreventive and anti-cancer agent |
| - | Review, | Var, | NA |
| 7593- | I3C, | Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells |
| - | Review, | Pca, | NA |
| 7594- | I3C, | Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers |
| - | Human, | Nor, | NA |
| 1277- | I3C, | GEN, | Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein |
| - | in-vitro, | PC, | PANC1 |
| 1278- | I3C, | Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin |
| - | in-vivo, | Pca, | DU145 |
| 7385- | IBC, | Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction |
| - | vitro+vivo, | Lung, | A549 | - | in-vitro, | BC, | 4T1 |
| 7801- | IBC, | Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter |
| - | in-vitro, | CRC, | HT-29 |
| 7770- | IBC, | Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction |
| - | in-vitro, | Lung, | NA | - | vitro+vivo, | BC, | 4T1 |
| 7802- | IBC, | Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression |
| - | in-vitro, | NA, | HepG2 |
| 7803- | IBC, | Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response |
| - | in-vivo, | Nor, | NA | - | in-vitro, | NA, | HepG2 |
| 7804- | IBC, | Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms |
| - | Review, | Nor, | NA |
| 7805- | IBC, | The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder |
| - | in-vivo, | Nor, | NA |
| 7806- | IBC, | Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway |
| - | in-vitro, | PC, | NA |
| 7807- | IBC, | Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | Hep3B | - | in-vitro, | Nor, | L02 |
| 7808- | IBC, | Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells |
| - | in-vitro, | Tong, | Tca8113 |
| 7809- | IBC, | Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways |
| - | in-vitro, | GC, | MGC803 |
| 7818- | IBC, | Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma |
| - | in-vitro, | neuroblastoma, | NA |
| 7767- | IBC, | Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway |
| - | vitro+vivo, | GC, | NA |
| 7768- | IBC, | Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells |
| - | in-vitro, | NA, | PC3 |
| 7769- | IBC, | Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters |
| - | in-vivo, | NA, | NA |
| 7776- | IBC, | Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation |
| - | vitro+vivo, | PC, | Panc02 |
| 7775- | IBC, | Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 7774- | IBC, | Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 |
| 7773- | IBC, | Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells |
| - | in-vitro, | Var, | NA |
| 7772- | IBC, | Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation |
| - | vitro+vivo, | AML, | NA |
| 7771- | IBC, | Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME |
| - | vitro+vivo, | Thyroid, | CAL-62 |
| 7709- | IBC, | Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 7710- | IBC, | Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice |
| - | vitro+vivo, | AD, | NA |
| 7711- | IBC, | Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo |
| - | vitro+vivo, | BC, | NA |
| 7578- | IMA, | Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia |
| - | Trial, | CML, | NA |
| 7579- | IMA, | One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial |
| - | Trial, | GC, | NA |
| 7613- | InA, | Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii |
| - | Study, | Nor, | NA |
| 7614- | InA, | Inoscavin A, a new free radical scavenger from the mushroom Inonotus xeranticus |
| - | Study, | Nor, | NA |
| 33- | InA, | Inoscavin A, a pyrone compound isolated from a Sanghuangporus vaninii extract, inhibits colon cancer cell growth and induces cell apoptosis via the hedgehog signaling pathway |
| - | vitro+vivo, | Colon, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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