γ-Toc, γ-Tocotrienol: Click to Expand ⟱
Features:
γ‐Tocotrienol is one of the tocotrienol isomers in the vitamin E family.
γ‐Tocotrienol is naturally found in certain plant oils.

– Notable sources include palm oil, rice bran oil, barley, and annatto.
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).

• Relationship within the Vitamin E Family
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).

Pathways:
-Inhibition of NF‑κB Signaling
-downregulate the PI3K/Akt signaling cascade
-inhibit STAT3 activation
-Cell Cycle Arrest
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)

Gamma E Complex (Tocopherols/Tocotrienols) example source
Scientific Papers found: Click to Expand⟱
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   ATP↓,1,   cMyc↓,1,   GlucoseCon↓,1,   Glycolysis↓,1,   HK2↓,1,   lactateProd↓,1,   LDHA↓,1,   p‑mTOR↓,1,   PFK↓,1,   PKM2↓,1,   TumCG↓,1,  
Total Targets: 12

Results for Effect on Normal Cells:

Total Targets: 0

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:321  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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