condition found tbRes List
AChE, acetylcholinesterase: Click to Expand ⟱
Source:
Type:
AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals.
- In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine.
- Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling.

For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA


Scientific Papers found: Click to Expand⟱
3562-   ACETYLCHOLINESTERASE AND GROWTH INHIBITORY EFFECTS–VARIOUS GRADES OF N. SATIVA OILS
- Review, AD, NA - Review, Var, NA
*AChE↓, *other↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↑, *TNF-α↑, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3514- Bor,  CUR,    Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta
- in-vivo, AD, NA
*DNAdam↓, *MDA↓, *AChE↓, *neuroP↑, *ROS↓, *NO↓,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↓, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam?, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↓, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓,
3316- SIL,  Chemo,    Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis
Inflam↓, antiOx↓, neuroP↑, cognitive↑, NRF2↑, HO-1↑, memory↑, AChE↓, Casp3↓,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3555- TQ,    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
- in-vivo, AD, NA
*memory↑, *BAX↓, *Aβ↓, *p‑tau↓, *AChE↓, *p‑Akt↓, *Ach↑, *Inflam↓,
3565- TQ,    Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model
*cognitive↑, *ROS↓, *SOD↑, *AChE↝, *Aβ↓,
3557- TQ,    Thymoquinone protects against lipopolysaccharides-induced neurodegeneration and Alzheimer-like model in mice.
- in-vivo, AD, NA
*Inflam↓, *antiOx↑, *cognitive↑, *TNF-α↓, *IL1β↓, *AChE↓, *IL10↑, *ChAT↑, *Aβ↓,
3561- TQ,    Studi In Silico Potensi Piperine, Piperlongumine, dan Thymoquinone Sebagai Obat Alzheimer
- NA, AD, NA
*AChE↓, *BBB↑,
3560- TQ,    Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *TAC↑, *AChE↓, *MDA↓, *NO↓, *TNF-α↓, *Bcl-2↑, *Ach↑, *neuroP↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↑, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   AChE↓,1,   Akt↓,2,   Akt↑,1,   p‑Akt↓,1,   angioG↓,1,   AntiCan↑,1,   antiOx↓,1,   APAF1↑,1,   Apoptosis↑,3,   AR↓,1,   BAX↑,2,   Bcl-2↓,1,   Beclin-1↑,1,   BNIP3↑,1,   cardioP↑,1,   Casp3↓,1,   Casp3↑,1,   Casp9↑,1,   proCasp9↓,1,   Catalase↓,1,   Catalase↑,1,   CDC2↓,1,   CDK2↓,2,   ChemoSen↑,2,   cognitive↑,2,   cycA1↑,1,   CycB↓,1,   Cyt‑c↑,1,   DR5↑,1,   E-cadherin↑,1,   p‑EGFR↓,1,   EMT↓,1,   p‑ERK↓,1,   FAK↓,1,   GSH↑,1,   GutMicro↑,1,   HO-1↑,1,   hTERT↓,1,   IGF-1R↓,1,   IL1↓,1,   IL6↓,1,   Inflam↓,1,   lipid-P↓,1,   MAPK↑,1,   MDM2↓,1,   MDR1↓,1,   memory↑,1,   MMP↓,1,   MMP2↓,1,   MMP9↓,1,   MMPs↓,1,   N-cadherin↓,1,   NADPH↓,1,   neuroP↑,1,   NF-kB↓,2,   NLRP3↓,1,   NOTCH↓,1,   NRF2↓,1,   NRF2↑,1,   P53↑,2,   PI3K↓,2,   ROS↓,2,   ROS↑,1,   Snail↓,1,   SOD↓,1,   SOD↑,1,   p‑STAT3↓,1,   TIMP2↑,1,   TNF-α↓,1,   Trx1↑,1,   TumCCA↑,2,   TumCG↓,1,   TumCMig↓,1,   TumCP↓,2,   TumMeta↓,1,   Twist↓,1,   VEGF↓,1,   Vim↓,1,  
Total Targets: 79

Results for Effect on Normal Cells:
5HT↑,1,   ACC↑,1,   Ach↑,4,   AChE↓,23,   AChE↝,1,   Akt↑,3,   p‑Akt↓,1,   p‑Akt↑,1,   AMPK↑,2,   antiOx↓,2,   antiOx↑,9,   AP-1↓,1,   Apoptosis↓,2,   ATP↑,1,   Aβ↓,10,   BAX↓,2,   BBB?,1,   BBB↓,1,   BBB↑,5,   BChE↓,2,   Bcl-2↑,2,   BioAv↓,1,   BioAv↑,7,   BioAv↝,1,   BP↓,1,   Ca+2↓,2,   cardioP↑,4,   Casp3↓,1,   Catalase↑,9,   ChAT↑,3,   Choline↑,1,   CHOP↓,1,   cMyc↓,1,   cognitive↑,14,   COX2↓,5,   CRP↓,2,   cycD1↓,1,   DNAdam↓,1,   Dose↝,1,   eff↑,1,   ERK↑,1,   p‑ERK↓,1,   Fas↓,1,   Ferritin↑,1,   GlucoseCon↑,2,   GLUT3↑,1,   GLUT4↑,1,   GPx↑,6,   GR↑,1,   GRP78/BiP↓,1,   GSH↑,10,   GSK‐3β↓,2,   GSR↓,1,   GSR↑,2,   GSTs↑,2,   GutMicro↑,1,   H2O2↓,2,   Half-Life↓,1,   HDAC↓,1,   hepatoP↑,4,   HO-1↑,8,   HO-2↓,1,   HSP70/HSPA5↑,1,   ICAM-1↓,1,   IFN-γ↓,1,   IFN-γ↑,1,   IGF-1↑,1,   IKKα↓,1,   IL10↑,3,   IL12↓,1,   IL17↓,1,   IL1β↓,9,   IL1β↑,1,   IL4↓,1,   IL6↓,4,   IL6↑,1,   Inflam?,1,   Inflam↓,12,   Inflam↑,1,   iNOS↓,6,   iNOS↑,1,   IRF3↓,1,   IronCh↑,2,   JNK↓,2,   JNK↑,1,   p‑JNK↓,1,   LDH↓,2,   LDL↓,1,   lipid-P↓,10,   MAPK↓,4,   MAPK↑,1,   MCP1↓,1,   MDA↓,8,   memory↑,12,   MMP↑,6,   MMP2↓,1,   MMP9↓,2,   motorD↑,3,   MPO↓,1,   mTOR↑,1,   MyD88↓,1,   NAD↑,1,   NADPH↓,1,   NADPH↑,1,   necrosis↓,1,   neuroP↑,18,   NF-kB↓,10,   NF-kB↑,1,   NLRP3↓,2,   NO↓,6,   NQO1↑,2,   NRF2↑,8,   other↓,1,   p‑p38↓,1,   Pain↓,1,   PGC-1α↑,1,   PGE2↓,1,   PI3K↑,2,   PKCδ↓,1,   PPARγ↑,1,   RenoP↑,1,   ROS↓,16,   mt-ROS↓,1,   SIRT3↑,1,   SOD↑,12,   SOD2↑,1,   Strength↑,1,   TAC↑,1,   tau↓,2,   p‑tau↓,3,   TBARS↓,1,   Telomerase↓,1,   TGF-β↓,1,   TLR1↓,1,   TLR2↓,1,   TLR4↓,3,   TLR4↑,1,   TNF-α↓,10,   TNF-α↑,1,   toxicity∅,1,   TRIF↓,1,   TumCI↓,1,   TumCP↓,1,   VCAM-1↓,1,   VEGF↓,1,   VitC↑,2,   VitE↑,1,   β-catenin/ZEB1↑,1,  
Total Targets: 148

Scientific Paper Hit Count for: AChE, acetylcholinesterase
7 Thymoquinone
4 Silymarin (Milk Thistle) silibinin
3 Quercetin
2 Alpha-Lipoic-Acid
2 Curcumin
1 Boron
1 Boswellia (frankincense)
1 Chrysin
1 Honokiol
1 Luteolin
1 Propolis -bee glue
1 Chemotherapy
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1329  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

Home Page