condition found tbRes List
ChAT, Choline acetyltransferase: Click to Expand ⟱
Source:
Type:
Choline acetyltransferase (ChAT) is the enzyme responsible for synthesizing acetylcholine (ACh), a key neurotransmitter involved in memory, learning, and attention.
In AD, one of the hallmark neurochemical findings is a loss of cholinergic neurons, especially in the basal forebrain, leading to:
↓ ChAT activity
↓ Acetylcholine (ACh) levels
↓ Cognitive function (especially memory and attention)

Many AD drugs aim to increase ACh levels by:
-Inhibiting acetylcholinesterase (AChE) (which breaks down ACh), e.g., donepezil, rivastigmine.


Scientific Papers found: Click to Expand⟱
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↑, *TNF-α↑, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3546- ALA,    Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study
- Study, AD, NA
*antiOx↑, *ROS↓, *cognitive∅, *lipid-P↓, *memory↑, *ChAT↑, *Acetyl-CoA↑, *Aβ↓, *BioAv↑, *BBB↑, *toxicity∅,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3557- TQ,    Thymoquinone protects against lipopolysaccharides-induced neurodegeneration and Alzheimer-like model in mice.
- in-vivo, AD, NA
*Inflam↓, *antiOx↑, *cognitive↑, *TNF-α↓, *IL1β↓, *AChE↓, *IL10↑, *ChAT↑, *Aβ↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Results for Effect on Cancer/Diseased Cells:
AMPK↑,2,   Apoptosis↑,1,   BioAv↝,1,   EGFR↓,1,   EGR4↓,1,   FDG↓,1,   Half-Life↓,1,   mTOR↓,1,   NF-kB↓,1,   PDH↑,1,   ROS↑,1,   TumCG↓,1,   TumCI↓,1,   TumCMig↓,1,   TumCP↓,1,  
Total Targets: 15

Results for Effect on Normal Cells:
5HT↑,2,   Acetyl-CoA↑,2,   Ach↑,6,   AChE↓,3,   Akt↑,1,   AntiAge↑,1,   AntiCan↑,1,   antiOx↑,8,   ATP↑,1,   Aβ↓,5,   BBB↑,4,   Bcl-2↑,1,   BioAv↓,1,   BioAv↑,4,   BioAv↝,3,   Ca+2↓,1,   cAMP↑,1,   cardioP↑,1,   Casp3↓,1,   Casp9↓,1,   Catalase↑,2,   ChAT↑,9,   cognitive↑,8,   cognitive∅,1,   COX2↓,1,   eff↑,1,   Ferritin↑,1,   GlucoseCon↑,4,   GLUT3↑,2,   GLUT4↑,2,   GPx↑,3,   GSH↑,6,   Half-Life↓,3,   hepatoP↑,1,   Hif1a↑,1,   HO-1↑,3,   HO-2↓,1,   IGF-1↑,1,   IL10↑,1,   IL1β↓,4,   IL1β↑,1,   IL2↓,1,   IL6↓,2,   INF-γ↓,1,   Inflam↓,7,   iNOS↓,1,   IronCh↑,6,   LDL↓,1,   lipid-P↓,5,   MDA↓,1,   memory↑,7,   motorD↑,1,   neuroP↑,7,   NF-kB↓,1,   NQO1↑,1,   NRF2↑,5,   other↓,1,   other↝,1,   PDH↑,1,   PDKs↓,1,   PGE2↓,1,   PI3K↑,1,   ROS↓,7,   ROS↑,1,   SIRT1↑,1,   SOD↑,3,   tau↓,1,   p‑tau↓,1,   TNF-α↓,3,   TNF-α↑,1,   toxicity∅,1,   VCAM-1↓,2,   VEGF↑,1,   VitC↑,2,   VitE↑,2,   Weight↓,1,  
Total Targets: 76

Scientific Paper Hit Count for: ChAT, Choline acetyltransferase
7 Alpha-Lipoic-Acid
1 Curcumin
1 Thymoquinone
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1346  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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