Acetyl-L-carnitine (ALC or ALCAR) is a naturally occurring molecule involved in mitochondrial energy metabolism.
-ALC supports mitochondrial energy metabolism by transporting fatty acids into mitochondria.
-Antioxidant effects: Reduces oxidative stress and lipid peroxidation.
-In cancer patients with fatigue or cachexia (wasting), ALC can improve energy metabolism and physical function.
-Acetyl-L-carnitine (ALC or ALCAR) levels are often reduced in Alzheimer's disease (AD) — especially in the brain and cerebrospinal fluid (CSF).
-ALC is present at high concentrations in the brain
-Carnitine is important in the β-oxidation of fatty acids and the acetyl portion can be used to maintain acetyl-CoA levels
-ALC is active in cholinergic neurons, where it is involved in the production of acetylcholine
-ALC significantly reduces Aβ-induced cytotoxicity, protein oxidation and lipid peroxidation in a concentration-dependent manner.
-ALC can cause an increase in the level of ADAM10
|