Database Query Results : Vitamin B5,Pantothenic Acid, ,

VitB5, Vitamin B5,Pantothenic Acid: Click to Expand ⟱
Features:
Vitamin B5 (Pantothenic Acid) plays several roles in the brain, and emerging evidence suggests it may be relevant to Alzheimer’s disease (AD)—particularly through its involvement in acetylcholine synthesis, energy metabolism, and oxidative stress response.
-Precursor to Coenzyme A (CoA)
-CoA is essential for mitochondrial energy production, lipid metabolism, and acetylcholine synthesis.
-CoA + choline → acetylcholine. ACh levels are reduced in AD; B5 deficiency may worsen this.
-Pantothenic acid is indirectly involved in cysteamine production, via CoA turnover.
-cysteamine can cross the BBB and increases BDNF levels.
-Pantothenic Acid (D-calcium pantothenate) Most common, stable, and well-absorbed form, water soluable
-Heat(cooking) may degrade the B5.
-Adequate Intake is 5mg/day. Target 10-15mg/day (300–900 mg/day under supervision)

-must be replenished daily; no long-term storage
Beef liver (3 oz cooked)   ~8.3 mg
Sunflower seeds (1 oz)	   ~2.0 mg
Chicken (3 oz cooked)	   ~1.0 mg
Salmon (3 oz cooked)	   ~1.6 mg
Avocado (1 whole)	   ~1.0–2.0 mg
Egg (1 large)	           ~0.7 mg
Mushrooms (½ cup cooked)   ~1.5 mg


Scientific Papers found: Click to Expand⟱
4317- VitB5,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Ach↑, *ROS↓, *Inflam↓, *p‑tau↓, *Aβ↓, *Acetyl-CoA↑, *ATP↑, *ChAT↑, *memory↑,
4323- VitB5,    Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease
- Study, AD, NA
*Risk↓, *Acetyl-CoA↑, *Ach↑, *neuroP↑,
4324- VitB5,    Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
- Study, AD, NA - Study, Park, NA
*Risk↓, *other↝, *other↝, *Ach↑, *Aβ↑, *other?,
4325- VitB5,    Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain
- Study, AD, NA - Study, Park, NA
*Risk↑, *Dose↝, *Dose↓, *other↝,
4326- VitB5,    Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
- in-vivo, HD, NA
*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, *Mood↑, *neuroP↑, *Inflam↓, *TNF-α↓, *BBB↝, *other↝, *Dose↝,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,
4334- VitB5,    Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model
- in-vivo, AD, NA
*neuroP↑, *motorD↑, *MMP↑, *OCR↑,
4335- VitB5,    Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
- Trial, NA, NA
*LDL↓,
4336- VitB5,    Effectiveness of long-term treatment with pantethine in patients with dyslipidemia
- Trial, NA, NA
*LDL↓, *HDL↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Results for Effect on Normal Cells:
Acetyl-CoA↑,2,   Ach↑,4,   adiP↑,1,   ALAT↓,1,   AST↓,1,   ATP↑,2,   Aβ↓,2,   Aβ↑,1,   BBB↝,2,   ChAT↑,1,   Dose↓,1,   Dose↝,2,   eff↓,1,   G6PD↑,1,   HDL↑,1,   IL1β↓,1,   Inflam↓,4,   LDL↓,3,   lipid-P↓,1,   memory↑,1,   MMP↑,1,   Mood↑,1,   motorD↑,1,   NADPH↑,1,   neuroP↑,5,   OCR↑,1,   other?,2,   other↝,7,   Risk↓,3,   Risk↑,1,   ROS↓,1,   p‑tau↓,1,   TGF-β↓,1,   TNF-α↓,1,  
Total Targets: 34

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:368  Target#:%  State#:%  Dir#:%
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