Database Query Results : , , BACE

BACE, β-site APP-cleaving enzyme: Click to Expand ⟱
Source:
Type:
BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.
Scientific Papers found: Click to Expand⟱
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
3884- Api,    Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,
3821- Aroma,    Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
- Review, AD, NA
*cognitive↑, *AChE↓, *BChE↓, *ROS↓, *other↓, *other↓, *other↓, *other↓, *other↓, *memory↑, *BACE↓, *Mood↑, *motorD↑,
3671- Ash,    Withania somnifera showed neuroprotective effect and increase longevity in Drosophila Alzheimer’s disease model
- in-vivo, AD, NA
*OS↑, *BACE↓,
4300- BBR,    Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis
- Review, AD, NA
*APP↓, *cognitive↑, *Aβ↓, *BACE↓, *tau?,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,
4082- betaCar,    Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis
- Study, AD, NA
*cognitive↑, *BACE↓, *memory↑,
3693- BM,    Bacopa monnieri prevents colchicine-induced dementia by anti-inflammatory action
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE↓, *Inflam↓, *ROS↓, *antiOx↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3860- CUR,    Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice
- in-vivo, AD, NA
*Aβ↓, *BACE↓, *memory↑,
3756- EA,    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
- Analysis, AD, NA
*AChE↓, *BACE↓, *MAOB↓,
3591- EGCG,    Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats
- in-vivo, AD, NA
*p‑tau↓, *BACE↓, *Aβ↓, *Ach↑, *AChE↓, *antiOx↑, *memory↑, *hepatoP↑, *ROS↓, *GPx↑, *SOD↑,
3830- EMD,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *BACE↓,
3782- FA,    Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
- in-vivo, AD, NA
*cognitive↑, *ERK↓, *p‑Akt↓, *AChE↓, *BACE↓, *neuroP↑, *ROS↓, *MDA↓, *GSH↑, *GSSG↓, *p‑tau↓, *lipid-P↓, *Aβ↓,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1↓, *IL6↓, *cognitive↑, *toxicity∅,
4211- Hup,    Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
- in-vitro, NA, NA
*memory↑, *p‑Akt↑, *BACE↓, *cognitive↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
3828- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer's disease
- in-vitro, AD, M146L
*ROS↓, *PI3K↑, *Akt↑, *NRF2↓, *antiOx↑, *BACE↓, *MDA↓,
3746- MF,    Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease
- in-vitro, AD, NA
*cognitive↑, *memory↑, *BACE↓,
3834- Moringa,    Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Aβ↓, *BACE↓, *cal2↓, *p‑tau↓, *ROS↓, *SOD↑, *MDA↓, *cognitive↑, *memory↑,
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
3604- QC,    Quercetin enrich diet during the early-middle not middle-late stage of alzheimer’s disease ameliorates cognitive dysfunction
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *neuroP↑, *BACE↓, *p‑SMAD2↓, *p‑STAT3↓, *SPARC↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
3736- RF,    Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1
- in-vivo, AD, NA
*cognitive↓, *BACE↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
4313- VitA,RetA,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*neuroP↑, memory↑, *Inflam↓, *neuroG↑, *cognitive↑, *Aβ↓, p‑tau↓, *BACE↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE↓, *ATP↑, *neuroP↑,
4034- VitB3,    Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models
- in-vivo, AD, NA
*cognitive↑, *NAD↑, *BACE↓, *Aβ↓, *PGC-1α↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE↓, *p‑tau↓, *p‑CREB↑, *p‑NF-kB↓, *neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 41

Results for Effect on Normal Cells:
Acetyl-CoA↓,1,   Ach↑,1,   AChE↓,11,   ADAM10↑,2,   AEP↓,1,   Akt↓,1,   Akt↑,2,   p‑Akt↓,1,   p‑Akt↑,1,   AMPK↑,4,   AntiAg↑,1,   AntiAge↑,1,   antiOx↓,1,   antiOx↑,16,   Apoptosis↓,2,   APP↓,8,   ATP↑,5,   Aβ↓,29,   BACE↓,40,   BACE↑,1,   BAX↓,1,   Bax:Bcl2↓,1,   BBB↑,7,   BChE↓,3,   Bcl-2↑,1,   BDNF↑,7,   BioAv↓,1,   BioAv↑,1,   BioAv↝,1,   BloodF↑,1,   BP∅,1,   Ca+2↓,2,   cal2↓,1,   cardioP↑,1,   Casp3↓,1,   Casp9↑,1,   Catalase↑,1,   CDK5↓,1,   cognitive↓,1,   cognitive↑,25,   COX2↓,5,   CREB↓,1,   CREB↑,2,   p‑CREB↑,3,   DNAdam↓,1,   Dose↝,1,   eff↑,6,   ER(estro)↓,1,   ERK↓,1,   ERK↑,1,   p‑ERK↑,1,   FAO↑,1,   FOXO3↑,1,   GlucoseCon↑,1,   GPx↑,2,   GRP78/BiP↑,1,   GSH↑,7,   GSK‐3β↓,2,   GSSG↓,1,   GSTs↑,1,   GutMicro↑,1,   Half-Life↑,1,   Half-Life↝,1,   hepatoP↑,1,   HO-1↑,5,   HSP70/HSPA5↑,2,   IDE↑,2,   IFN-γ↓,1,   IL10↑,1,   IL17↓,1,   IL1β↓,9,   IL23↓,1,   IL33↓,1,   IL6↓,8,   IL8↓,1,   Inflam↓,15,   iNOS↓,6,   IRF3↓,1,   IronCh↑,1,   LDL↓,2,   lipid-P↓,7,   LRP1↑,1,   MAOA↓,1,   MAOB↓,2,   MAPK↓,1,   MAPK↑,1,   MCP1↓,2,   MDA↓,5,   memory↑,20,   MMP9↓,2,   Mood↑,2,   motorD↑,1,   MPO↓,2,   mtDam↓,1,   mTOR↓,1,   MyD88↓,1,   NAD↑,1,   NADPH↓,1,   NADPH↑,1,   NEP↑,1,   neuroG↑,1,   neuroP↑,21,   NF-kB↓,7,   p‑NF-kB↓,2,   NLRP3↓,4,   NO↓,2,   NQO1↑,3,   NRF2↓,1,   NRF2↑,6,   OS↑,2,   other↓,6,   other↑,3,   PGC-1α↓,1,   PGC-1α↑,1,   PI3K↓,1,   PI3K↑,2,   PKA↑,2,   PP2A↑,3,   PPARγ↓,1,   PPARγ↑,2,   PSD95↑,1,   RenoP↑,2,   Risk↓,1,   ROS↓,24,   SIRT1↑,3,   p‑SMAD2↓,1,   SOD↑,6,   SOD1↑,1,   SPARC↓,1,   p‑STAT3↓,1,   STEP↓,1,   TAC↑,1,   tau?,1,   tau↓,2,   p‑tau↓,14,   TfR1/CD71↓,1,   TLR2↓,1,   TLR4↓,1,   TNF-α↓,9,   toxicity↓,1,   toxicity∅,1,   TrkB↑,1,   TrxR↑,2,   TXNIP↓,1,   UPR↑,1,   VEGF↑,1,  
Total Targets: 146

Scientific Paper Hit Count for: BACE, β-site APP-cleaving enzyme
3 Berberine
3 Curcumin
3 Huperzine A/Huperzia serrata
3 Resveratrol
2 EGCG (Epigallocatechin Gallate)
2 Ginseng
2 Hydrogen Gas
2 Moringa oleifera
2 Quercetin
2 Sulforaphane (mainly Broccoli)
2 Vitamin B3,Niacin
1 Anthocyanins
1 Apigenin (mainly Parsley)
1 Aromatherapy
1 Ashwagandha
1 beta-carotene(VitA)
1 Bacopa monnieri
1 Ellagic acid
1 Emodin
1 Ferulic acid
1 Luteolin
1 Lycopene
1 Magnetic Fields
1 Mushroom Lion’s Mane
1 EMF
1 Thymoquinone
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid
1 Vitamin D3
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1349  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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