Database Query Results : , , MAOB

MAOB, Monoamine oxidase B: Click to Expand ⟱
Source:
Type:
Monoamine oxidase B (MAO-B) is an enzyme involved in the metabolism of monoamines, especially dopamine and phenylethylamine, primarily in the brain. Its activity has been implicated in both Alzheimer's disease (AD) and cancer, but in very different contexts. -Increased MAO-B expression is observed in the brains of aging individuals and even more so in AD patients, particularly in astrocytes.
-High MAO-B activity may accelerate β-amyloid (Aβ) and tau pathology.
-MAO-B inhibitors are potential agents to combat neurodegenerative diseases, including AD and Parkinson’s disease

MAO-B inhibitors have shown anti-cancer effects in preclinical models:
   Inducing apoptosis in tumor cells.
   Sensitizing cells to chemotherapy or radiotherapy.
   Inhibiting tumor angiogenesis and invasion.


Scientific Papers found: Click to Expand⟱
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3756- EA,    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
- Analysis, AD, NA
*AChE↓, *BACE↓, *MAOB↓,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
3943- Shank,    Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach
- Review, AD, NA
*neuroP↑, *memory↑, *other↝, *AChE↓, *MAOA↓, *MAOB↓, *TrkB↓, *tau↓, *APP↓, *ROS↓, *Mood↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Results for Effect on Normal Cells:
5HT↑,1,   AChE↓,6,   Akt↓,1,   angioG↑,1,   antiOx↓,1,   antiOx↑,3,   Apoptosis↓,2,   APP↓,3,   Aβ↓,3,   BACE↓,2,   BAX↑,1,   BBB↑,1,   BChE↓,2,   Bcl-2↑,1,   Casp3↓,1,   CD31↑,1,   cognitive↑,2,   Dose↝,1,   GSH↑,2,   IL10↓,1,   IL1β↓,1,   IL1β↑,1,   Inflam↓,1,   iNOS↓,1,   LDL↓,1,   lipid-P↓,3,   MAOA↓,3,   MAOB↓,6,   MAPK↓,1,   MDA↓,1,   memory↑,4,   Mood↑,1,   N-cadherin↑,1,   neuroP↑,4,   NF-kB↓,1,   NO↓,1,   other↝,1,   PI3K↓,1,   RNS↓,1,   ROS↓,4,   SOD↓,1,   tau↓,1,   p‑tau↓,3,   TNF-α↓,2,   toxicity↓,1,   TrkB↓,1,   VEGF↑,1,  
Total Targets: 47

Scientific Paper Hit Count for: MAOB, Monoamine oxidase B
3 Berberine
1 Ellagic acid
1 Ginkgo biloba
1 Shankhpushpi
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1352  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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