Database Query Results : , , CDK5

CDK5, Cyclin-dependent kinase 5: Click to Expand ⟱
Source:
Type:
CDK5 is primarily expressed in neurons and is important for normal brain development, synaptic function, and neuronal signaling. However, CDK5 becomes dysregulated in AD, contributing to neurodegeneration. -CDK5 is generally upregulated or hyperactivated in both cancer and Alzheimer's disease (AD)
Scientific Papers found: Click to Expand⟱
3793- CUR,    Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *memory↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3728- MF,    Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *Apoptosis↓, *ROS↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
3796- QC,  BBR,    Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
- Review, AD, NA
*CDK5↓,
3792- RosA,    Molecular docking and dynamics simulations revealed the potential inhibitory activity of honey-iQfood ingredients against GSK-3β and CDK5 protein targets for brain health
- Analysis, AD, NA
*CDK5↓, *GSK‐3β↓,
3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, *ChAT↑, *NGF↑, *CDK5↓, *neuroP↑, *MDA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Results for Effect on Normal Cells:
AChE↓,3,   AMPK↑,1,   AntiAge↑,1,   antiOx↑,1,   Apoptosis↓,1,   Aβ↓,2,   BACE↓,1,   BDNF↑,1,   Catalase↑,1,   CDK5↓,7,   ChAT↑,1,   cognitive↑,1,   COX2↓,1,   Dose↝,1,   GSH↑,1,   GSK‐3β↓,5,   GutMicro↑,1,   HO-1↑,2,   IL10↑,1,   IL12↓,1,   IL17↓,1,   IL1β↓,1,   IL23↓,1,   IL4↑,1,   IL6↓,1,   Inflam↓,1,   IronCh↑,1,   LDL↓,1,   lipid-P↓,1,   MCP1↓,1,   MDA↓,1,   memory↑,2,   MPO↓,1,   mTOR↓,1,   NADPH↓,1,   neuroP↑,3,   NF-kB↓,1,   NGF↑,1,   NLRP3↓,1,   NQO1↑,1,   NRF2↑,2,   OS↑,1,   PPARγ↑,1,   ROS↓,3,   SIRT1↑,1,   SOD↑,2,   p‑tau↓,4,   TNF-α↓,2,   TXNIP↓,1,  
Total Targets: 49

Scientific Paper Hit Count for: CDK5, Cyclin-dependent kinase 5
3 Curcumin
1 Magnetic Fields
1 Quercetin
1 Berberine
1 Rosmarinic acid
1 Shankhpushpi
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1358  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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