Database Query Results : , , PSD95

PSD95, Postsynaptic density protein 95: Click to Expand ⟱
Source:
Type:
PSD95 (Postsynaptic density protein 95) is a critical scaffolding protein in excitatory synapses, particularly abundant in the postsynaptic density (PSD) of neurons. It plays a key role in synaptic signaling and plasticity, including anchoring NMDA receptors and organizing signaling complexes.
-↓ PSD95 levels in hippocampus and cortex in AD patients and models.
-Loss of PSD95 impairs synaptic plasticity (e.g., LTP) and memory formation
-Hyperphosphorylated tau disrupts PSD95-mediated signaling.
-Agents that preserve or restore PSD95 levels show cognitive benefits in models
Scientific Papers found: Click to Expand⟱
3797- CUR,    Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice
- in-vitro, NA, NA
*cognitive↑, *BDNF↑, *PSD95↑, *memory↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4231- Lut,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
4227- Lyco,    Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway
- in-vivo, NA, NA
*BDNF↑, *TrkB↑, *PSD95↑,
3740- MF,    Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *Dose↝, *Aβ↓, *PSD95↑,
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, NA, NA
*SIRT1↑, *BDNF↑, *PSD95↑, *memory↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Results for Effect on Normal Cells:
AChE↓,1,   AEP↓,1,   antiOx↑,2,   Apoptosis↓,1,   APP↓,1,   Aβ↓,2,   BACE↓,1,   Bax:Bcl2↓,1,   BBB↑,1,   BDNF↑,7,   BioAv↑,1,   Casp3↓,1,   Casp3↑,1,   cognitive↑,5,   CREB↑,1,   p‑CREB↑,1,   Dose↝,1,   ER Stress↓,1,   ERK↑,1,   FTL↓,1,   GPx↑,1,   GSTA1↑,1,   IDE↑,1,   Inflam↓,2,   Iron↓,2,   LRP1↑,1,   MDA↓,1,   MDA↑,1,   memory↑,4,   Mood↑,2,   NADPH↓,1,   NEP↑,1,   neuroP↑,4,   NOX↓,1,   PKA↑,1,   PSD95↑,9,   ROS↓,2,   SIRT1↑,1,   SOD↑,2,   STEP↓,1,   TfR1/CD71↓,2,   TrkB↑,1,  
Total Targets: 42

Scientific Paper Hit Count for: PSD95, Postsynaptic density protein 95
2 Huperzine A/Huperzia serrata
1 Curcumin
1 Lutein
1 Lycopene
1 Magnetic Fields
1 Moringa oleifera
1 Pterostilbene
1 Resveratrol
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1359  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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