Database Query Results : , , STEP

STEP, STriatal-Enriched protein tyrosine Phosphatase: Click to Expand ⟱
Source:
Type:
STEP (STriatal-Enriched protein tyrosine Phosphatase)(also known as PTPN5) is a brain-specific phosphatase that plays a significant role in synaptic plasticity and cognitive function. It is particularly relevant in the context of Alzheimer's disease (AD) due to its dysregulation in this neurodegenerative condition.
- upregulated/hperactive in AD Brains.
- leads to disruption i learning and memory.
- Inhibition of STEP has shown to improve cognition and synaptic function in AD models
- Enhancing SIRT1 downregulated STEP indirectly.
Scientific Papers found: Click to Expand⟱
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Results for Effect on Normal Cells:
AChE↓,1,   AEP↓,1,   antiOx↑,1,   APP↓,1,   Aβ↓,1,   BACE↓,1,   cognitive↑,1,   IDE↑,1,   Inflam↓,1,   LRP1↑,1,   memory↑,1,   Mood↑,1,   NEP↑,1,   neuroP↑,1,   PSD95↑,1,   STEP↓,1,  
Total Targets: 16

Scientific Paper Hit Count for: STEP, STriatal-Enriched protein tyrosine Phosphatase
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1367  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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