Database Query Results : , , ADAM10

ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10: Click to Expand ⟱
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ADAM10 (A Disintegrin And Metalloproteinase Domain-Containing Protein 10) plays a critical protective role in Alzheimer’s disease (AD) due to its function as an α-secretase, an enzyme involved in the non-amyloidogenic processing of the amyloid precursor protein (APP).
-By preventing Aβ accumulation, ADAM10 indirectly reduces amyloid plaques.br> -Downregulation of ADAM10 is observed in AD brains.
-ADAM10 levels are especially diminished in individuals with an APOE4 genotype
Scientific Papers found: Click to Expand⟱
3859- ALC,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*ROS↓, *ADAM10↑,
3855- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Risk↓, *Aβ↓, *p‑tau↓, *Inflam↓, *neuroP↑, *cognitive↑, *ADAM10↑, *PPARα↑,
3856- CUR,    Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase
- in-vitro, AD, NA
*ADAM10↑, *Inflam↓,
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*Inflam↓, *antiOx↑, *IronCh↑, *BBB↑, *ADAM10↝,
3861- CUR,    Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
- Review, Var, NA
*antiOx↑, *Inflam↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, NF-kB↓, HH↓, NOTCH↓, JAK↓, STAT3↓, ADAM10↓,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
*SIRT1↑, *ADAM10↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
3863- RES,  MEL,  VitA,RetA,    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
- Review, AD, NA - Review, Park, NA
*ADAM10↑, *ADAM10↑, *ADAM10↑,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Results for Effect on Normal Cells:
Acetyl-CoA↓,1,   ADAM10↑,10,   ADAM10↝,1,   Akt↑,1,   AMPK↑,1,   AntiAg↑,1,   antiOx↑,4,   APP↓,1,   Aβ↓,3,   BACE↓,2,   BBB↑,1,   cognitive↑,2,   CREB↑,1,   eff↑,1,   ERK↑,1,   FAO↑,1,   IDE↑,1,   Inflam↓,5,   IronCh↑,1,   LDL↓,1,   MAPK↑,1,   memory↑,2,   neuroP↑,4,   NRF2↑,1,   PI3K↑,1,   PKA↑,1,   PP2A↑,2,   PPARα↑,1,   PPARγ↓,1,   Risk↓,1,   ROS↓,2,   SIRT1↑,2,   p‑tau↓,3,  
Total Targets: 33

Scientific Paper Hit Count for: ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10
4 Curcumin
4 Resveratrol
1 Acetyl-l-carnitine
1 Capsaicin
1 Ginseng
1 Melatonin
1 Vitamin A, Retinoic Acid
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1368  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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