Database Query Results : , , PP2A

PP2A, serine/threonine phosphatase: Click to Expand ⟱
Source:
Type:
Protein Phosphatase 2A (PP2A) plays a critical role in Alzheimer’s disease (AD), especially in relation to tau pathology.
-PP2A dephosphorylates tau, thus reducing its toxicity.
-MID1 Negatively Regulates PP2A
-In AD, PP2A activity is decreased, leading to accumulation of hyperphosphorylated tau.
-Amyloid-β (Aβ) peptides may inhibit PP2A, indirectly promoting tau pathology.
-Aβ and tau pathologies are interconnected, and PP2A sits at a crossroads of both.

Some natural products that might upregulate PP2A:
-resveratrol
-Sodium selenate
-Berberine
-Fisetin
-Metformin (via indirect mechanisms)
Scientific Papers found: Click to Expand⟱
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Results for Effect on Normal Cells:
Acetyl-CoA↓,1,   ADAM10↑,2,   Akt↑,3,   AMPK↑,3,   AntiAg↑,1,   antiOx↑,3,   APP↓,1,   Aβ↓,3,   BACE↓,3,   BAX↓,1,   Bcl-2↑,1,   BDNF↑,1,   Beclin-1↑,1,   CaMKII ↓,1,   cognitive↑,2,   CREB↑,1,   p‑CREB↑,1,   eff↑,1,   ERK↑,1,   FAO↑,1,   GSH↑,2,   GSK‐3β↓,3,   HO-1↑,1,   IDE↑,1,   IL1β↓,1,   IL6↓,1,   Inflam↓,2,   iNOS↓,1,   LC3II↑,1,   lipid-P↓,1,   MAPK↑,1,   MDA↓,1,   memory↑,5,   MMP9↓,1,   neuroP↑,4,   NF-kB↓,1,   NLRP3↓,1,   NRF2↑,1,   PGC-1α↓,1,   PI3K↑,2,   PKA↑,2,   PP2A↑,6,   PPARγ↓,1,   ROS↓,2,   SIRT1↑,2,   p‑tau↓,6,  
Total Targets: 46

Scientific Paper Hit Count for: PP2A, serine/threonine phosphatase
4 Resveratrol
1 Berberine
1 Ginseng
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1371  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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