Database Query Results : , , BChE

BChE, butyrylcholinesterase: Click to Expand ⟱
Source:
Type:
BChE is an enzyme that hydrolyzes choline-based esters. In the brain, it works alongside acetylcholinesterase (AChE) to regulate levels of the neurotransmitter acetylcholine. Since cholinergic deficits are a hallmark of AD, both enzymes have been studied in relation to AD pathology.
- In some AD patients, BChE activity increases relative to AChE.
- Aβ neurotoxicity is amplified when BChE is added to Aβ in tissue culture
Scientific Papers found: Click to Expand⟱
3817- Aroma,    Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms
- Review, AD, NA
*BChE↓, *AChE↓, *other↓, *other?, *Ach?, *eff↑, *antiOx↑, *ROS↓, *cognitive↑, *Mood↑, *Sleep↑,
3821- Aroma,    Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
- Review, AD, NA
*cognitive↑, *AChE↓, *BChE↓, *ROS↓, *other↓, *other↓, *other↓, *other↓, *other↓, *memory↑, *BACE↓, *Mood↑, *motorD↑,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,
3749- BBR,    Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE?,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
3784- CA,  CGA,    Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro
- Study, AD, NA
*AChE↓, *BChE↓, *eff↑, *ROS↓, *neuroP↑,
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
*BChE↓, *AChE↓, *Ach↑, *cognitive↑, *memory↑, *ROS↓, *Inflam↓, *NF-kB↓, *COX2?,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3781- FA,    Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *AChE↓, *BChE↓,
3779- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *COX2↓, *Casp↓, *NOS2↓, *HO-1↑, *AChE∅, *BChE∅, *memory↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
4085- Se,    Role of micronutrients in Alzheimer's disease: Review of available evidence
- Review, AD, NA
*AChE↓, *BChE↓, *antiOx↑, *memory↑, *cognitive↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Results for Effect on Normal Cells:
5LO↓,1,   Ach?,1,   Ach↑,2,   AChE↓,16,   AChE∅,1,   Akt↓,1,   Akt↑,1,   AMPK↑,1,   antiOx↓,1,   antiOx↑,9,   Apoptosis↓,1,   APP↓,1,   Aβ↓,6,   BACE↓,3,   BBB?,1,   BBB↑,3,   BChE?,1,   BChE↓,14,   BChE∅,1,   BDNF↓,1,   BioAv↑,1,   Ca+2↓,1,   cardioP↑,1,   Casp↓,1,   Casp3↓,1,   Catalase↑,3,   ChAT↑,1,   cognitive↑,7,   COX2?,1,   COX2↓,2,   Dose↝,1,   eff↑,4,   p‑ERK↓,1,   GPx↑,1,   GSH↑,3,   GSK‐3β↓,1,   GutMicro↑,1,   H2O2↓,1,   hepatoP↑,1,   HO-1↑,4,   HSPs↝,1,   IKKα↓,1,   IL1β↓,2,   IL4↓,1,   Inflam↓,7,   iNOS↓,1,   IronCh↑,1,   p‑JNK↓,1,   LDL↓,2,   lipid-P↓,5,   MAOA↓,2,   MAOB↓,2,   MAPK↓,2,   MDA↓,2,   memory↑,10,   MMP↑,2,   Mood↑,2,   motorD↑,1,   necrosis↓,1,   neuroP↑,7,   NF-kB↓,6,   NLRP3↓,1,   NOS2↓,1,   NRF2↑,1,   other?,1,   other↓,6,   p‑p38↓,1,   PI3K↓,1,   PI3K↑,1,   RenoP↑,1,   RNS↓,1,   ROS↓,12,   Sleep↑,1,   SOD↑,3,   SOD2↑,1,   Strength↑,1,   tau↓,2,   p‑tau↓,2,   TLR4↓,1,   TNF-α↓,3,   toxicity↓,1,  
Total Targets: 81

Scientific Paper Hit Count for: BChE, butyrylcholinesterase
4 Berberine
3 Ferulic acid
2 Aromatherapy
2 Curcumin
2 Caffeic acid
1 Ashwagandha
1 EGCG (Epigallocatechin Gallate)
1 Huperzine A/Huperzia serrata
1 Chlorogenic acid
1 Galantamine
1 Quercetin
1 Selenium
1 Silymarin (Milk Thistle) silibinin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:606  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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