NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱
Source:
Type:
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.
Scientific Papers found: Click to Expand⟱
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, eff↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
2434- 2DG,    Inhibition of Key Glycolytic Enzyme Hexokinase 2 Ameliorates Psoriasiform Inflammation in vitro and in vivo
- in-vitro, PSA, NA - in-vivo, PSA, NA
HK2↓, NF-kB↓, NLRP3↓,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
5146- AgNPs,    Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent
- in-vitro, Liver, HepG2
TumAuto↑, EPR↑, LC3B↑, CHOP/DDIT3↑, ER Stress↑, NLRP3↑, Casp1↓,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
3393- ART/DHA,    Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis
- in-vivo, Col, NA
*ROS↓, *NLRP3↓, *Inflam↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2↓, *p62↓, *NP/CIPN↓,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
3519- Bor,    Boron-Based Inhibitors of the NLRP3 Inflammasome
- Review, NA, NA
NLRP3↓,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *eff↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5875- CA,    Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway
- in-vivo, IBD, NA
*antiOx↑, *Weight↑, *p65↓, *cJun↓, *NLRP3↓, *Casp1↓, *NRF2↑, *GSH↑, *SOD↑, *MDA↓, *iNOS↓, other↝,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1↓, LDHA↓, GLUT1↓, ECAR↓,
5988- Chit,    Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways
- Review, Var, NA
DDS↑, *Cartilage↑, *Wound Healing↑, Imm↑, cGAS–STING↑, STAT1↑, NLRP3↑, *DCells↑, *IL10↓, *TGF-β1↓, *TNF-α↓, IL1β↓, ROS↑,
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
6316- Cro,    NLRP3_pathway_inhibition">Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCI↓, Apoptosis↑, TLR4↓, NF-kB↓, IKKα↓, NLRP3↓, TumCG↓,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
3225- EGCG,    Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway
- in-vitro, Nor, NA - in-vivo, Nor, NA
*RenoP↑, *NLRP3↓, *TXNIP↓, *ASC↓, *Casp1↓, *IL1β↓, *ROS↓, *TNF-α↓, *IL6↓, *IL18↓,
3224- EGCG,    Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis
- in-vitro, Nor, NA
*Casp1↓, *NLRP3↓, *Inflam↓,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE↓, *LC3II↓, *Beclin-1↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
7052- Gallo,    Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment
- in-vivo, Colon, SW48
TumCMig↓, TumCI↓, NLRP3↓, LDH↓, Inflam↓, IL6↓, TNF-α↓, IL1β↓,
7269- GGB,    Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease
- in-vivo, AD, NA
*Inflam↓, *cognitive↑, *NLRP3↓, *neuroP↑,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
854- Gra,  AgNPs,    Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
- vitro+vivo, AML, THP1 - in-vitro, AML, AMJ13 - vitro+vivo, lymphoma, HBL
TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
4345- H2,    The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
- Human, NA, NA
*Inflam↓, *antiOx↑, *ROS↓, *NLRP3↑, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAg↑,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3787- H2,    Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis
- Review, AD, NA
*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,

Showing Research Papers: 1 to 50 of 108
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 108

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   Buty↑, 1,   compII↑, 1,   diuretic↑, 1,   GLP-1R↑, 1,   SCFAs↑, 1,   SpO2↑, 1,   Stroke↓, 2,   TMAO↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 24,   ARE↑, 2,   Bil↑, 2,   Catalase↑, 11,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 5,   GPx1↑, 1,   GSH↑, 5,   GSTA1↑, 1,   HNE↓, 1,   HO-1↑, 17,   lipid-P↓, 8,   MDA↓, 10,   MPO↓, 4,   MPO↑, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↑, 21,   PARK2↑, 1,   RNS↓, 1,   ROS↓, 31,   ROS↑, 2,   ROS↝, 1,   mt-ROS↓, 1,   SIRT3↑, 2,   SOD↑, 15,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   compIII↑, 1,   MMP↓, 1,   MMP↑, 2,   mtDam↓, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 4,   AMPK↑, 8,   cAMP↑, 1,   CREB↑, 2,   glucose↓, 1,   LDL↓, 4,   NADPH↓, 5,   NADPH↑, 1,   PPARγ↓, 1,   PPARγ↑, 4,   SIRT1↑, 8,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Akt↑, 6,   Apoptosis↓, 2,   ASK1↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Casp9↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 5,   JNK↓, 3,   p‑JNK↓, 1,   MAPK?, 1,   MAPK↓, 5,   p‑MAPK?, 1,   p‑MAPK↓, 1,   p38↓, 3,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   cJun↓, 1,   other↓, 1,   other↑, 1,   other↝, 5,   TFAM↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   cl‑PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   ERK↑, 1,   FOXO↑, 1,   FOXO3↑, 3,   GSK‐3β↓, 5,   mTOR↓, 5,   p‑mTOR↓, 1,   neuroG↑, 1,   PI3K↓, 2,   PI3K↑, 5,   PTEN↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   APP↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 1,   CDK5↓, 1,   CLDN1↓, 1,   COL1↓, 1,   Fibrosis↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   PKA↑, 1,   PKCδ↑, 2,   RAGE↓, 1,   TGF-β↑, 1,   TGF-β1↓, 2,   TJ↓, 1,   TJ↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TXNIP↓, 2,   VCAM-1↓, 3,   ZO-1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   Hif1a↓, 1,   NO↓, 5,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   IBI↑, 2,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2↓, 9,   DCells↑, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 3,   IFN-γ↓, 2,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 4,   IL12↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 13,   IL2↓, 1,   IL2↑, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 16,   IL8↓, 2,   Imm↑, 3,   Inflam?, 1,   Inflam↓, 33,   Inflam↑, 1,   JAK2↓, 1,   JAK2↑, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 23,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 7,   RANTES↓, 1,   TLR3↓, 1,   TLR4↓, 7,   TNF-α↓, 18,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   AChE↓, 4,   BChE↓, 1,   BDNF↑, 7,   BrainVol↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 1,   tau↓, 1,   p‑tau↓, 3,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 10,   BACE↓, 3,   NLRP3↓, 35,   NLRP3↑, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 10,   BioAv↝, 3,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 6,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   AST↓, 4,   Bil↑, 2,   BloodF↑, 2,   creat↓, 1,   GutMicro↑, 8,   IL6↓, 16,   MUC19↓, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 2,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 6,   cognitive↓, 2,   cognitive↑, 9,   hepatoP↑, 8,   memory↑, 10,   neuroP↑, 18,   NP/CIPN↓, 1,   Obesity↓, 4,   OS↑, 2,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 5,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 3,   Weight↑, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 5,   Sepsis↓, 5,  
Total Targets: 259

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3
11 Hydrogen Gas
9 Resveratrol
5 Quercetin
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
4 Thymoquinone
3 Silver-NanoParticles
3 Cucurbitacin
3 EGCG (Epigallocatechin Gallate)
3 Ferulic acid
3 Piperlongumine
3 Pterostilbene
3 Silymarin (Milk Thistle) silibinin
3 Urolithin
3 Vitamin C (Ascorbic Acid)
2 Beta-Caryophyllene
2 Carnosic acid
2 Chlorogenic acid
2 Curcumin
2 Emodin
2 Luteolin
2 Magnetic Fields
2 Methylsulfonylmethane
1 1,8-Cineole
1 2-DeoxyGlucose
1 Selenite (Sodium)
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Cannabidiol
1 Boron
1 Butyrate
1 Caffeic acid
1 Celastrol
1 chitosan
1 Choline
1 Crocetin
1 Fucoidan
1 Galloflavin
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 hydrogen sulfide
1 Lycopene
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Phenylbutyrate
1 Propolis -bee glue
1 Radiotherapy/Radiation
1 Selenium
1 doxorubicin
1 Selenium NanoParticles
1 Shikonin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:908  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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