Database Query Results : , , ERK

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
Scientific Papers found: Click to Expand⟱
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, NA, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
2598- Ba,    Baicalein inhibits melanogenesis through activation of the ERK signaling pathway
- in-vitro, Melanoma, B16-F10
other↓, other?, ERK↑,
2624- Ba,    Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression
- in-vitro, Nor, RAW264.7
*HO-1↑, *ERK↑, *ROS↓, *eff↑, *MMP↑, *Cyt‑c∅,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
1382- BBR,    Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28
Apoptosis↑, necrosis↑, DNAdam↑, TumCCA↑, ROS↑, Casp3↑, p‑P53↑, ERK↑,
2690- BBR,    Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice
- in-vivo, Diabetic, NA
*Inflam↓, *Th17↓, *Th1 response↓, *ERK↑, *p38↓, *JNK↓, *STAT1↓, *STAT4↓, *MAPK↓,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
4175- CUR,    Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- in-vivo, NA, NA
*BDNF↑, *ERK↑,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
3712- FA,    Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- Review, AD, NA
*antiOx↑, *Inflam↓, *ROS↓, *Aβ↓, *HO-1↑, *HSP70/HSPA5↑, *ERK↑, *Akt↑, *iNOS↓, *COX2↓, *cardioP↑, *memory↑, *IL2↓, *cognitive↑, *APP↓, *SOD↑, *Catalase↑, *Akt↑, *BioAv↑,
2850- FIS,    Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways
- in-vitro, BC, MCF-7
TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, NA, NA
*ERK↑, *BDNF↑, *CREB↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4343- H2,    Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation
- vitro+vivo, NA, NA
*antiOx↑, *AntiAg↑, *NO↑, *ERK↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
4146- MF,    Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neurons
- in-vivo, AD, NA
*BDNF↑, *ERK↑,
189- MFrot,  MF,    Cancer treatment by magneto-mechanical effect of particles, a review
- vitro+vivo, Var, NA
CellMemb↑, lysoMP↑, ERK↑, Apoptosis↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP↑, AR↓, other?,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
4704- PTS,  Cisplatin,    Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS
- in-vitro, Bladder, NA
PI3K↓, mTOR↓, P70S6K↓, MEK↑, ERK↑, ChemoSen↑, TumAuto↑,
41- QC,    Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
- vitro+vivo, AML, HL-60
Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, PARP↑, MMP↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
4198- SFN,    Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways
- vitro+vivo, AD, NA
*TrkB↑, *CREB↑, CaMKII ↑, *ERK↑, *ac‑H3↑, *ac‑H4↑, *HDAC↓, *HDAC2↓, *BDNF↑,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
2231- SK,    Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
- in-vitro, CRC, SNU-407
Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, NA, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
3134- VitC,    Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway
- in-vitro, Nor, HUVECs
*ERK↑,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 51

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 2,   GSH↑, 1,   H2O2↑, 1,   MDA↓, 1,   NRF2↑, 3,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 18,   SOD↓, 1,   SOD↑, 2,   SOD2↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   EGF↓, 1,   FGFR1↓, 2,   MEK↑, 1,   MMP↓, 7,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 3,   CAIX↓, 1,   cMyc↓, 3,   Glycolysis↓, 1,   lactateProd↑, 1,   LDH↓, 1,   LDH↑, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 9,   ASK1↑, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 12,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Casp↑, 4,   Casp12?, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 11,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 8,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   Diablo↑, 2,   DR5↑, 2,   Fas↑, 1,   FasL↑, 2,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 6,   lysoMP↑, 1,   MAPK↓, 2,   MAPK↑, 6,   p‑MAPK↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27↑, 1,   p38↓, 2,   p38↑, 6,   p‑p38↑, 3,   survivin↓, 1,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↑, 1,   HER2/EBBR2↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   miR-21↑, 1,   other?, 2,   other↓, 1,   p‑pRB↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

cl‑ATF6↑, 1,   CHOP↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 3,   GRP78/BiP↓, 1,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   p62↓, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   DNArepair↓, 1,   DNMTs↓, 1,   P53↑, 5,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 4,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   CDK4↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 3,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 2,   EMT↓, 6,   EMT↑, 1,   ERK↓, 2,   ERK↑, 27,   FGF↓, 1,   HDAC↓, 2,   IGFBP3↑, 2,   Jun↓, 1,   miR-34a↑, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   mTORC1↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   P70S6K↓, 2,   PI3K↓, 5,   PI3K↝, 1,   PTEN↑, 1,   RAS↓, 1,   Shh↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   STAT6↓, 1,   TumCG↓, 4,   Wnt↓, 2,  

Migration ⓘ

Ca+2↑, 2,   mt-Ca+2↑, 1,   E-cadherin↑, 4,   ER-α36↓, 1,   FAK↓, 2,   Ki-67↓, 2,   MET↓, 1,   MMP1↓, 1,   MMP2↓, 8,   MMP7↓, 1,   MMP9↓, 8,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   PKCδ↓, 2,   Rho↓, 1,   Slug↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TSP-1↑, 2,   TumCI↓, 5,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 2,   TumCP↓, 5,   TumMeta↓, 3,   Twist↓, 2,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   ATF4↑, 1,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↝, 1,   NO↑, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CRP↓, 1,   CXCR4↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 1,   JAK2↓, 2,   NF-kB↓, 7,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 8,   Dose↝, 1,   Dose∅, 2,   eff↓, 5,   eff↑, 15,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 4,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMD↑, 1,   CRP↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 1,   ChemoSideEff↓, 2,   cognitive?, 1,   NDRG1↑, 1,   neuroP↑, 1,   OS↑, 1,   Risk↓, 2,   toxicity∅, 1,   TumW↓, 2,  
Total Targets: 245

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 7,   Catalase↑, 4,   GPx↑, 4,   GSH↓, 1,   GSH↑, 4,   GSR↑, 1,   H2O2↓, 1,   H2O2∅, 1,   HO-1↑, 6,   Iron↓, 1,   Keap1↓, 1,   MDA↓, 2,   NRF2↑, 7,   Prx↑, 1,   ROS↓, 9,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 6,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 2,   adiP↑, 1,   AMPK↑, 2,   cAMP↑, 1,   p‑cMyc↑, 1,   CREB↑, 7,   glucose↑, 1,   GlucoseCon↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↑, 9,   p‑Akt↑, 1,   Apoptosis↓, 1,   BMP2↑, 1,   Casp3↓, 3,   Casp6↓, 1,   Casp9↓, 2,   Cyt‑c∅, 1,   iNOS↓, 2,   iNOS↑, 1,   JNK↓, 3,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 5,   p38↓, 2,   p38↑, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   other↝, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   ERK↑, 24,   GSK‐3β↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   IGF-1↑, 1,   mTOR↑, 1,   PI3K↑, 4,   PTEN↓, 2,   STAT1↓, 1,   STAT4↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APP↓, 2,   Ca+2↓, 1,   MMP9↓, 2,   PKA↑, 3,   PKCδ↓, 1,   PKCδ↑, 2,   VCAM-1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

eNOS↑, 1,   NO↓, 2,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 3,   GLUT1↑, 1,   GLUT4↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   ICAM-1↓, 1,   IL10↑, 1,   IL1β↓, 3,   IL2↓, 1,   IL6?, 1,   IL6↓, 2,   Inflam↓, 10,   NF-kB↓, 5,   p‑NF-kB↓, 1,   Th1 response↓, 1,   Th17↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 8,   BDNF∅, 1,   GABA↑, 1,   PSD95↑, 1,   p‑tau↓, 2,   TrkB↑, 2,  

Protein Aggregation ⓘ

Aβ↓, 4,   Aβ↑, 1,   BACE↓, 1,   IDE↑, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 3,   Dose↝, 1,   eff↓, 1,   eff↑, 4,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP↓, 1,   BP↝, 1,   IL6?, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 4,   cognitive↑, 7,   hepatoP↑, 1,   memory↑, 6,   motorD↑, 1,   neuroP↑, 11,   radioP↑, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 136

Scientific Paper Hit Count for: ERK, ERK signaling
3 Alpha-Lipoic-Acid
3 Baicalein
3 Berberine
3 Magnetic Fields
3 Quercetin
3 Sulforaphane (mainly Broccoli)
2 Radiotherapy/Radiation
2 Curcumin
2 Ferulic acid
2 Fisetin
2 Pterostilbene
2 Thymoquinone
2 Vitamin K2
1 Allicin (mainly Garlic)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Baicalin
1 Caffeic acid
1 Propolis -bee glue
1 Chrysin
1 EGCG (Epigallocatechin Gallate)
1 flavonoids
1 Ginseng
1 Hydrogen Gas
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Luteolin
1 Lycopene
1 Magnetic Field Rotating
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Cisplatin
1 Salvia officinalis
1 Rosmarinic acid
1 Aromatherapy
1 Shikonin
1 Vitamin C (Ascorbic Acid)
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:105  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page