Database Query Results : , , Half-Life

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.


Scientific Papers found: Click to Expand⟱
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
2716- BetA,    Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment
- Review, Var, NA
AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
2809- CUR,    Comparative absorption of curcumin formulations
- in-vivo, Nor, NA
BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↓, Half-Life↝,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2922- LT,    Combination of transcriptomic and proteomic approaches helps unravel the mechanisms of luteolin in inducing liver cancer cell death via targeting AKT1 and SRC
- in-vitro, Liver, HUH7
Half-Life↝, TumCCA↑, AKT1↓, ATF2↓, NF-kB↓, GSK‐3β↓, cMyc↓, GSTs↓, TrxR1↓, ROS↑,
2543- M-Blu,    The use of methylene blue to control the tumor oxygenation level
- in-vivo, Lung, NA
OCR↑, OXPHOS↑, Half-Life↝, AntiTum↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
3247- PBG,    Bioavailability and In Vivo Antioxidant Activity of a Standardized Polyphenol Mixture Extracted from Brown Propolis
- Review, NA, NA
Half-Life↝, BioAv↓, Half-Life↝, BioAv↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3915- PS,    Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
- Trial, AD, NA
*memory↑, *cognitive↑, *Half-Life↝, *Mood↑,
4693- PTS,    Pterostilbene in the treatment of inflammatory and oncological diseases
BioAv↑, *Inflam↓, *antiOx↑, AntiTum↑, BBB↑, Half-Life↝, *ROS↓, *NRF2↑, *NQO1↑, *HO-1↑, PTEN↑, miR-19b↓, TumCCA↑, ER Stress↑, PERK↑, ATF4↑, CHOP↑, Ca+2↝, EMT↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, ChemoSen↑, toxicity∅, toxicity↝,
2442- RES,    High absorption but very low bioavailability of oral resveratrol in humans
- in-vitro, Nor, NA
BioAv↝, Half-Life↝, BioAv↓, eff↝,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27↑, TumCCA↑, ChemoSen↑, COX2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
3019- RosA,    Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
- in-vivo, Nor, NA
*BioAv↝, *Half-Life↝, *Half-Life↑, *Half-Life↝, *BioAv↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3291- SIL,    Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
- Review, Nor, NA
*antiOx↑, *ROS↓, *cardioP↑, *BioAv↓, *Half-Life↝, *other↑, IronCh↑,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
4600- SNP,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1↑, *ROS↓, *GutMicro↑, *Risk↓,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, NA, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 50

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned

chemoPv↑, 1,  

Redox & Oxidative Stress

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   Fenton↑, 2,   GPx↓, 1,   GSH↓, 7,   GSR↓, 1,   GSTs↓, 2,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   OXPHOS↓, 1,   OXPHOS↑, 1,   Prx4↑, 1,   ROS↓, 5,   ROS↑, 20,   ROS⇅, 2,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD2↓, 2,   TrxR↓, 2,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology

IronCh↑, 1,  

Mitochondria & Bioenergetics

AIF↑, 1,   ATP↓, 2,   MMP↓, 10,   OCR↓, 1,   OCR↑, 1,   c-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis

ACLY↓, 1,   AKT1↓, 1,   AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 4,   CYP3A4↓, 1,   FASN↓, 2,   GlutMet↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   LDH↓, 1,   LDH↝, 1,   PDK1↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↓, 2,   SIRT2↑, 1,   SREBP1↓, 1,  

Cell Death

Akt↓, 9,   p‑Akt↓, 4,   Apoptosis↑, 8,   ATF2↓, 1,   BAD↑, 1,   Bak↑, 3,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 3,   Casp↑, 2,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 12,   Casp7↑, 3,   Casp8↑, 4,   Casp9↑, 9,   Cyt‑c↑, 9,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   Fas↑, 3,   FasL↑, 1,   GADD34↑, 1,   HGF/c-Met↓, 2,   IAP1↓, 1,   IAP2↑, 1,   JNK↑, 4,   p‑JNK↑, 2,   MAPK↓, 4,   MAPK↑, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27↑, 5,   p38↑, 2,   p‑p38↑, 2,   survivin↓, 6,   Telomerase↓, 4,   TumCD↑, 1,  

Kinase & Signal Transduction

cSrc↓, 1,   EF-1α↓, 1,   HER2/EBBR2↓, 1,   p70S6↓, 2,   p‑p70S6↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics

cJun↓, 1,   cJun↑, 1,   H3↓, 1,   H3↑, 1,   H4↓, 1,   H4↑, 1,   HATs↑, 2,   miR-21↓, 1,   other↑, 1,   other↝, 1,   other∅, 1,   tumCV↓, 2,  

Protein Folding & ER Stress

ATF6↑, 1,   CHOP↓, 1,   CHOP↑, 4,   cl‑CHOP↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 1,   IRE1∅, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes

ATG5↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair

CHK1↓, 1,   DNAdam↑, 5,   DNMTs↓, 1,   P53↑, 9,   PARP↑, 3,   cl‑PARP↑, 9,   PCNA↓, 3,  

Cell Cycle & Senescence

CDK2↓, 3,   CDK4↓, 5,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   P21?, 1,   P21↑, 9,   p‑RB1↓, 2,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State

4E-BP1↓, 1,   CD133↓, 1,   CD34↓, 1,   CD44↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 3,   EMT↓, 10,   EMT↑, 1,   ERK↓, 6,   p‑ERK↓, 1,   FOXO3↑, 1,   FOXO4↑, 1,   GSK‐3β↓, 3,   HDAC↓, 4,   HDAC2↓, 1,   HDAC3↓, 1,   HH↓, 2,   IGF-1?, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   miR-34a↑, 1,   mTOR↓, 12,   mTORC1↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 3,   NOTCH3↓, 2,   OCT4↓, 1,   PI3K↓, 7,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 7,   RAS↓, 2,   SOX2↓, 1,   p‑Src↓, 1,   STAT1↓, 1,   STAT3↓, 11,   STAT6↓, 1,   p‑STAT6↓, 1,   TumCG↓, 2,   Wnt↓, 3,  

Migration

5LO↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   FAK↓, 2,   p‑FAK↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-19b↓, 1,   miR-203↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP9↓, 7,   MMPs↓, 4,   MUC4↓, 1,   N-cadherin↓, 3,   PDGF↓, 1,   Rac1↓, 2,   Rho↓, 1,   Snail↓, 1,   SOX4↓, 1,   SOX4↑, 1,   TGF-β↓, 2,   TIMP1↑, 1,   Treg lymp↓, 1,   TumCI↓, 6,   TumCMig↓, 6,   TumCP↓, 10,   TumMeta↓, 7,   Twist↓, 4,   Tyro3↓, 1,   uPA↓, 4,   Vim↓, 3,   Vim↑, 1,   Zeb1↓, 2,   ZO-1↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature

angioG↓, 7,   angioG↑, 1,   ATF4↑, 3,   ATF4↝, 1,   EGFR↓, 4,   EGFR↑, 1,   Hif1a↓, 9,   Hif1a↝, 1,   NO↑, 1,   TAMS↓, 1,   TAMS↝, 1,   VEGF↓, 12,   VEGFR2↓, 2,  

Barriers & Transport

BBB↑, 2,   GLUT1↓, 1,   NHE1↓, 1,   P-gp↓, 4,   sonoP↑, 1,  

Immune & Inflammatory Signaling

ASC↓, 1,   COX2↓, 8,   CXCR4↓, 2,   ICAM-1↓, 2,   IKKα↓, 2,   IL1↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 5,   IL8↓, 3,   Inflam↓, 5,   IκB↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 17,   p‑NF-kB↑, 1,   p65↓, 2,   p‑p65↓, 2,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 4,   TNF-α↓, 4,  

Protein Aggregation

NLRP3↓, 1,  

Hormonal & Nuclear Receptors

AR↓, 4,   CDK6↓, 3,  

Drug Metabolism & Resistance

BioAv↓, 18,   BioAv↑, 16,   BioAv↝, 3,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↑, 14,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 9,   eff↑, 20,   eff↝, 3,   Half-Life↓, 3,   Half-Life↝, 28,   MDR1↓, 3,   MRP1↓, 1,   P450↓, 1,   RadioS↑, 8,   selectivity↑, 12,  

Clinical Biomarkers

AR↓, 4,   CEA↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 4,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 5,   LDH↓, 1,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 4,  

Functional Outcomes

AntiCan↑, 5,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 8,   ChemoSideEff↓, 2,   hepatoP↑, 2,   neuroP↑, 1,   OS↑, 2,   radioP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 2,  
Total Targets: 346

Pathway results for Effect on Normal Cells:


NA, unassigned

chemoPv↑, 3,  

Redox & Oxidative Stress

antiOx↓, 1,   antiOx↑, 16,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 6,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 9,   GSTA1↑, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 7,   Keap1↓, 1,   lipid-P↓, 6,   mt-lipid-P↓, 1,   MDA↓, 6,   Mets↝, 1,   MPO↓, 3,   NQO1↑, 4,   NRF2↑, 9,   PARK2↑, 1,   RNS↓, 1,   ROS↓, 21,   SIRT3↑, 1,   SOD↑, 9,   SOD1↑, 2,   SOD2↑, 2,   TBARS↓, 1,   TOS↓, 1,   TrxR↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology

IronCh↑, 2,  

Mitochondria & Bioenergetics

ATP↑, 1,   MMP↑, 1,   OCR↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis

ALAT↓, 1,   AMPK↑, 5,   p‑cMyc↑, 1,   H2S↑, 1,   LDH↓, 2,   NADH:NAD↑, 1,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 3,  

Cell Death

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Cyt‑c∅, 1,   iNOS↓, 5,   JNK↓, 2,   p‑MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics

other↓, 1,   other↑, 3,   other↝, 2,  

Protein Folding & ER Stress

HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↑, 1,  

Autophagy & Lysosomes

Beclin-1↑, 1,   MitoP↑, 1,  

DNA Damage & Repair

P53↓, 1,  

Cell Cycle & Senescence

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State

ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   IGFBP3↑, 1,   mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Migration

AntiAg↑, 2,   AP-1↓, 2,   APP↓, 1,   Ca+2↓, 1,   Cartilage↑, 1,   CD31↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↑, 1,   TGF-β↑, 1,   TIMP1↓, 1,   VCAM-1↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature

angioG↑, 1,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↑, 2,  

Barriers & Transport

BBB↓, 1,   BBB↑, 7,  

Immune & Inflammatory Signaling

COX2↓, 8,   ICAM-1↓, 1,   IL1↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 7,   IL6↓, 7,   IL8↓, 4,   Inflam↓, 19,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 3,   TLR4↓, 1,   TNF-α↓, 10,   TNF-α↑, 1,  

Synaptic & Neurotransmission

BDNF↑, 1,   ChAT↑, 1,  

Protein Aggregation

Aβ↓, 5,   BACE↓, 2,   NLRP3↓, 2,  

Drug Metabolism & Resistance

BioAv↓, 8,   BioAv↑, 9,   BioAv↝, 5,   Dose↑, 2,   Dose↝, 7,   eff↑, 10,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 26,  

Clinical Biomarkers

ALAT↓, 1,   AST↓, 1,   Bil↑, 1,   BMD↑, 2,   BP↓, 2,   creat↓, 1,   GutMicro↑, 3,   IL6↓, 7,   LDH↓, 2,  

Functional Outcomes

AntiCan↑, 1,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 1,   cognitive↑, 6,   hepatoP↓, 1,   hepatoP↑, 4,   memory↓, 1,   memory↑, 5,   Mood↑, 1,   motorD↓, 1,   motorD↑, 1,   neuroP↑, 11,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 169

Scientific Paper Hit Count for: Half-Life, Half-Life
4 Resveratrol
3 Boron
3 Silymarin (Milk Thistle) silibinin
3 Shikonin
2 Ashwagandha(Withaferin A)
2 Berberine
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Honokiol
2 Luteolin
2 Rosmarinic acid
2 Thymoquinone
2 Urolithin
1 Allicin (mainly Garlic)
1 Artemisinin
1 Betulinic acid
1 Vitamin D3
1 Aspirin -acetylsalicylic acid
1 Ferulic acid
1 itraconazole
1 Methylene blue
1 Methylsulfonylmethane
1 Oleuropein
1 HydroxyTyrosol
1 Propolis -bee glue
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Phosphatidylserine
1 Pterostilbene
1 SonoDynamic Therapy UltraSound
1 Sulforaphane (mainly Broccoli)
1 Silver-NanoParticles
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1109  State#:0  Dir#:4
wNotes=0 sortOrder:rid,rpid

 

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