Database Query Results : , , CLDN2

CLDN2, claudin-2: Click to Expand ⟱
Source:
Type:
Claudin-2 is a member of the claudin family of tight junction proteins that regulate paracellular permeability and influence cell signaling.

• High expression of CLDN2 has been associated in several studies with enhanced tumor aggressiveness, increased invasiveness, and, in some cancers (e.g., colorectal and hepatocellular carcinoma), poorer prognostic outcomes.
Scientific Papers found: Click to Expand⟱
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1↓, CycB↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Results for Effect on Cancer/Diseased Cells:
Akt↓,2,   p‑Akt↓,1,   angioG↓,1,   AntiAg↓,1,   Apoptosis↑,1,   BAX↑,2,   i-Ca+2↑,1,   Casp3↓,1,   Casp3↑,1,   cl‑Casp3↑,1,   cl‑Casp8↑,2,   Casp9↑,1,   CDK1↓,1,   p‑CDK1↓,1,   CDK6↓,1,   cFLIP↓,1,   ChemoSen↑,2,   CLDN2↓,2,   cMyc↓,1,   COX2↓,1,   CXCL12↓,1,   CXCR4↓,1,   cycA1↓,1,   CycB↓,1,   cycD1↓,2,   Cyt‑c↑,2,   Diablo↑,1,   DNMTs↓,1,   E-cadherin↑,1,   eff↑,7,   EGFR↓,1,   eIF2α↑,1,   EMT↓,1,   ER Stress↑,2,   p‑ERK↓,1,   FOXO3↓,1,   GRP78/BiP↑,1,   GSK‐3β↓,1,   H3↓,1,   ac‑H3↑,1,   ac‑H4↑,1,   HDAC↓,1,   Hif1a↓,1,   HK2↓,1,   IL10↓,1,   IL6↓,1,   iNOS↓,1,   Ki-67↓,1,   LDHA↓,1,   lipid-P↑,1,   MMP↓,3,   MMP2↓,1,   MMP9↓,1,   MMPs↓,1,   p‑mTOR↓,1,   N-cadherin↓,1,   NF-kB↓,1,   NO↓,1,   P21↑,1,   p27↑,1,   P53↑,1,   P70S6K↓,1,   cl‑PARP↑,1,   PARP1↑,1,   PCNA↓,1,   PERK↑,1,   PFK↓,1,   PI3K↓,1,   PKCδ↓,1,   PKM2↓,1,   PTEN↑,1,   PUMA↑,1,   RadioS↑,1,   ROS↓,1,   ROS↑,4,   Snail↓,1,   STAT3↓,1,   TGF-β↓,1,   TLR4↓,1,   TSP-1↑,1,   TumCCA↑,2,   TumCMig↓,1,   TumCP↓,1,   TumMeta↓,1,   uPA↓,1,   UPR↑,1,   VEGF↓,1,   VEGFR2↓,1,   Vim↓,1,   α-tubulin↓,1,   β-catenin/ZEB1↓,1,  
Total Targets: 91

Results for Effect on Normal Cells:
AntiCan↑,1,   antiOx↑,1,   Inflam↓,1,  
Total Targets: 3

Scientific Paper Hit Count for: CLDN2, claudin-2
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1163  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page