Database Query Results : , , Keap1

Keap1, Kelch-like ECH-associated protein 1: Click to Expand ⟱
Source:
Type:
Kelch-like ECH-associated protein 1 (Keap1) is a key regulator of the transcription factor Nrf2.

-In several tumor types, loss of Keap1 function (either due to gene mutations or low protein expression) results in unrestrained Nrf2 activity.
• Persistent Nrf2 activation is thought to:
 - Provide tumor cells with enhanced protection against oxidative stress.
 - Contribute to chemoresistance and radioresistance.
 - Promote metabolic reprogramming that fuels tumor growth.

• Thus, in many cancers, altered Keap1 status can serve as an indicator of poor prognosis and has been investigated as a potential target for therapeutic intervention.
Scientific Papers found: Click to Expand⟱
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3173- Ash,    Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
- in-vitro, neuroblastoma, NA
GPx4↓, HO-1↑, lipid-P↑, Keap1↓, NRF2↑, Ferroptosis↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
3216- EGCG,    Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation
- NA, Colon, Caco-2
NRF2↑, TumCP↓, mt-ROS↓, Keap1↓,
3219- EGCG,    Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling
- in-vitro, Lung, A549
ROS↑, RNS↓, MMP↓, NRF2↑, Keap1↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
*antiOx↑, *Keap1↓, *NRF2↑, *HO-1↑, *GPx↑, *SOD↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
2126- TQ,    Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway
- Review, Nor, NA
*antiOx↑, *Bacteria↓, *RenoP↑, *hepatoP↑, *neuroP↑, *Inflam↓, *Keap1↓, *NRF2↑, *other↝,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Results for Effect on Cancer/Diseased Cells:
Akt↓,3,   angioG↓,1,   AntiCan↑,1,   Apoptosis↑,1,   ATP↓,2,   BAX↑,2,   Bcl-2↓,3,   Beclin-1↓,1,   BioAv↓,1,   Casp↑,1,   Casp12↑,1,   Casp3↑,2,   Casp8↑,1,   Casp9↑,2,   CD8+↑,1,   CDK2↓,1,   CDK4↓,1,   CDK6↓,2,   chemoP↑,1,   ChemoSen↑,1,   CHK1↓,1,   CK2↓,1,   COX2↓,2,   CRP↓,1,   CSCs↓,1,   CycB↓,1,   cycD1↓,1,   cycE↓,1,   Cyt‑c↑,2,   E-cadherin↑,1,   eff↑,2,   EGFR↓,1,   EMT↓,1,   ERK↓,1,   ERK↑,1,   p‑FAK↓,1,   Fas↑,1,   Ferroptosis↑,1,   Fibronectin↓,1,   FOXO4↓,1,   GlutMet↓,1,   GPx4↓,1,   GSH↓,3,   GSSG↑,1,   HIF-1↓,1,   Hif1a↓,2,   HO-1↑,3,   HSP27↝,1,   HSP70/HSPA5↝,1,   IFN-γ↓,1,   IGF-1↓,2,   IL1β↓,1,   IL6↓,2,   IL8↓,2,   iNOS↓,2,   Keap1↓,5,   Ki-67↓,1,   lipid-P↑,1,   MAPK↑,1,   Mcl-1↓,1,   MMP↓,2,   MMP1↓,1,   MMP2↓,2,   MMP3↓,1,   MMP7↓,1,   MMP9↓,2,   mTOR↓,3,   NF-kB↓,1,   NO↓,1,   NOTCH1↓,1,   NRF2↑,6,   other⇅,1,   P21↑,1,   p38↑,1,   P53?,1,   P53↑,1,   p62↓,1,   P70S6K↓,1,   cl‑PARP↑,2,   PD-1↓,1,   PFK↓,1,   PGE2↓,1,   PI3K↓,2,   PI3K/Akt↓,1,   POLD1↓,1,   RadioS↑,1,   RNS↓,1,   ROS?,1,   ROS↑,5,   mt-ROS↓,1,   selectivity↑,1,   SIRT1↑,1,   Slug↓,1,   SMAD2↓,1,   SMAD3↓,1,   Snail↓,1,   SOD↑,1,   STAT3↓,1,   TGF-β↓,1,   Th1 response↑,1,   TNF-α↓,2,   TumCCA↑,4,   TumCI↓,1,   TumCMig↓,1,   TumCP↓,3,   tumCV↓,2,   TumMeta↓,1,   VEGF↓,3,   VEGFR2↓,1,   Vim?,1,   Wnt↓,1,   Zeb1↓,1,  
Total Targets: 112

Results for Effect on Normal Cells:
Akt↓,1,   ALAT↓,3,   Albumin↑,1,   ALP↓,1,   angioG↑,1,   AntiCan↑,1,   antiOx↑,8,   Apoptosis↓,2,   AST↓,3,   ATF6↓,1,   Aβ↓,1,   Bacteria↓,1,   BBB↑,2,   BP↓,1,   cardioP↑,3,   Catalase↑,3,   Catalase↝,1,   chemoP↑,1,   CLDN5↑,1,   cognitive↑,1,   COX2↓,3,   creat↓,1,   DNAdam↓,1,   eff↑,1,   ER Stress↓,1,   GPx↑,5,   GPx↝,1,   GR↝,1,   GRP78/BiP↓,1,   GSH↑,4,   GSH/GSSG↓,1,   GSR↑,1,   GSS↑,1,   GSTs↑,1,   GutMicro↑,1,   H2S↑,1,   Half-Life↝,1,   hepatoP↑,4,   HO-1↑,6,   HO-1⇅,1,   IL10↑,1,   IL1β↓,1,   IL6↓,2,   Inflam↓,6,   iNOS↓,3,   Keap1↓,13,   LDH↓,2,   LDHA↓,1,   lipid-P↓,2,   MDA↓,4,   memory↑,2,   MMP↑,1,   MPO↓,1,   mtDam↓,1,   neuroP↑,5,   NF-kB↓,2,   NO↓,1,   NQO1↑,1,   NRF2↑,14,   other↑,2,   other↝,1,   p62↑,1,   PCNA↑,1,   PGE2↓,1,   PI3K↓,1,   PKM2↓,1,   RenoP↑,2,   ROS↓,9,   ROS∅,1,   SIRT1↑,1,   SOD↑,6,   SOD↝,1,   SOD1↑,1,   SOD2↑,1,   TBARS↓,1,   TGF-β↓,1,   TIMP1↓,1,   TNF-α↓,3,   Trx↑,1,   ZO-1↑,1,  
Total Targets: 80

Scientific Paper Hit Count for: Keap1, Kelch-like ECH-associated protein 1
3 Resveratrol
2 EGCG (Epigallocatechin Gallate)
2 Quercetin
1 Allicin (mainly Garlic)
1 Ashwagandha
1 Boron
1 Selenium
1 Capsaicin
1 Fisetin
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Lycopene
1 Magnetic Fields
1 Piperlongumine
1 Thymoquinone
1 Vitamin K2
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1174  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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