Database Query Results : , , ROCK1

ROCK1, Rho-associated coiled-coil containing protein kinase 1: Click to Expand ⟱
Source:
Type:
ROCK1 (Rho-associated coiled-coil containing protein kinase 1)
– ROCK1 is a serine/threonine kinase and a major effector of the Rho GTPase signaling pathway.

– Elevated expression of ROCK1 has been observed in various cancers, including breast, prostate, lung, colorectal, and gastric cancers.

– In many tumors, ROCK1 overexpression correlates with increased cell motility, invasion, and metastatic potential.
Scientific Papers found: Click to Expand⟱
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, Foxm1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   angioG↓,1,   BMPs↑,1,   Ca+2↑,1,   CDK2↓,1,   CDK4↓,1,   CDK6↓,1,   cFLIP↓,1,   cJun↓,1,   COX2↓,1,   cycD1↓,1,   Cyt‑c↑,1,   ECAR↓,1,   Endon↑,1,   ERK↓,1,   FAK↓,1,   Foxm1↓,1,   FOXO3↑,1,   Hif1a↓,1,   HO-1↓,1,   HSPs↓,1,   iNOS↓,1,   JNK↓,1,   MEK↓,1,   MMP↓,1,   MMP-10↓,1,   MMP2↓,2,   MMP7↓,1,   MMP9↓,1,   mTOR↓,1,   NF-kB↓,2,   OCR↑,1,   P-gp↓,1,   P21↑,1,   p27↑,1,   p38↓,1,   p65↓,1,   PI3K↓,2,   RAS↓,2,   Rho↑,1,   ROCK1↑,2,   ROS↑,1,   TumCCA↓,1,   TumCMig↓,1,   Twist↓,1,   uPA↓,1,   VEGF↓,2,  
Total Targets: 47

Results for Effect on Normal Cells:
AntiAg↑,1,   antiOx↑,1,   Aβ↓,1,   BBB↑,1,   BioAv↓,1,   cardioP↑,1,   Casp3↓,1,   ERK↓,1,   Keap1↑,1,   memory↑,1,   neuroP↑,1,   NF-kB↓,1,   NRF2↑,1,   PGC-1α↑,1,   PPARγ↑,1,   Rho↓,1,   ROS↓,2,   SIRT3↑,1,  
Total Targets: 18

Scientific Paper Hit Count for: ROCK1, Rho-associated coiled-coil containing protein kinase 1
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1284  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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