Database Query Results : , , IKKα

IKKα, IκB kinase alpha): Click to Expand ⟱
Source:
Type:
Expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα) IKKα (IκB kinase alpha) is a critical component of the NF-κB signaling pathway, which plays a significant role in regulating immune responses, inflammation, and cell survival.
The NF-κB pathway, activated by IKKα, can lead to the production of pro-Inhibitors of the NF-κB pathway, including those targeting IKKα, are being investigated for their potential to treat various cancers.inflammatory cytokines that may create a tumor-promoting microenvironment.
Scientific Papers found: Click to Expand⟱
3167- Ash,    Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
- in-vitro, MM, H226
TumCP↓, cMyc↓, cFos↓, cJun↓, TIMP2↑, Vim↓, ROS↑, BAX↑, IKKα↑, Casp3↑, cl‑PARP↑,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2728- BetA,    Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy
- in-vitro, Var, NA
NF-kB↑, IKKα↑, eff↓,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2884- HNK,    Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP
- in-vitro, Lung, A549 - in-vitro, Lung, H460
EMT↓, cFLIP↓, N-cadherin↓, Snail↓, p‑SMAD2↓, p‑SMAD3↓, IKKα↑, TumCMig↓, NA↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2385- MET,    Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
- in-vitro, AD, H4 - in-vitro, NA, HEK293 - in-vivo, NA, NA - in-vitro, NA, SH-SY5Y
*HK2↓, *PKM2↓, *Dose↝, IKKα↑, memory↑, p‑Hsc70↑, APP↓,
1940- PL,    Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Results for Effect on Cancer/Diseased Cells:
Akt↓,2,   p‑Akt↓,1,   Apoptosis↑,3,   APP↓,1,   ATF3↑,1,   BAD↑,1,   BAX↑,3,   Bcl-2↓,2,   Bcl-xL↓,1,   BMPs↑,1,   Casp3↑,2,   Casp8↑,1,   Casp9↑,1,   cl‑Casp9↑,1,   CD133↓,1,   cFLIP↓,2,   cFos↓,1,   chemoP↑,1,   CHOP↑,2,   cJun↓,1,   p‑cJun↑,1,   p‑cMET↑,1,   cMyc↓,1,   CXCR4↓,1,   Cyt‑c↑,2,   eff↓,2,   eff↝,1,   EGFR↓,1,   eIF2α↑,1,   EMT↓,1,   ER Stress↑,2,   ERK↓,2,   p‑ERK↑,1,   GRP78/BiP↑,2,   GSH↓,1,   GSK‐3β↑,1,   p‑GSK‐3β↓,1,   HDAC↓,1,   p‑Hsc70↑,1,   IFN-γ↑,1,   IKKα↑,9,   p‑IKKα↓,1,   IL4↑,1,   IL6↑,1,   IRE1↑,1,   JNK↑,1,   p‑JNK↑,2,   memory↑,1,   MMP↓,3,   MMPs↓,1,   mTOR↓,1,   p‑mTOR↓,1,   mTORC1↓,1,   N-cadherin↓,1,   NA↑,1,   Nestin↓,1,   NF-kB↓,4,   NF-kB↑,1,   NOXA↑,1,   p38↑,1,   p‑p38↑,1,   P53↑,1,   cl‑PARP↑,1,   p‑PERK↑,1,   PI3K↓,2,   PTEN↑,1,   RAS↑,1,   ROS↑,4,   selectivity↑,2,   Shh↓,1,   p‑SMAD2↓,1,   p‑SMAD3↓,1,   Snail↓,1,   p‑STAT3↓,1,   T-Cell↑,1,   TIMP2↑,1,   TLR1↑,1,   TLR2↑,1,   TLR4↑,1,   TumAuto↑,1,   TumCG↓,1,   TumCI↓,1,   TumCMig↓,2,   TumCP↓,2,   TumCP∅,1,   tumCV↓,2,   TumVol↓,1,   TumW↓,1,   Twist↓,1,   VEGF↓,1,   Vim↓,1,  
Total Targets: 91

Results for Effect on Normal Cells:
ALAT↓,1,   ALP↓,1,   antiOx↑,1,   AST↓,1,   cardioP↑,1,   Casp3↓,1,   Catalase↑,1,   COX2↓,1,   Dose↝,1,   GSH↑,1,   hepatoP↑,1,   HK2↓,1,   HO-1↑,1,   IKKα↑,1,   IL10↓,1,   IL6↓,1,   Inflam↓,1,   NADPH↓,1,   neuroP↑,1,   NF-kB↓,1,   NRF2↑,1,   P-gp↓,1,   PGE2↓,1,   PKM2↓,1,   p‑Rac1↓,1,   RenoP↑,1,   ROS↓,2,   TNF-α↓,1,  
Total Targets: 28

Scientific Paper Hit Count for: IKKα, IκB kinase alpha)
2 Honokiol
1 Ashwagandha
1 Baicalein
1 Betulinic acid
1 Fenbendazole
1 Fisetin
1 Metformin
1 Piperlongumine
1 Salvia miltiorrhiza
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:156  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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