Database Query Results : , , PARP

PARP, poly ADP-ribose polymerase (PARP) cleavage: Click to Expand ⟱
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Type:
Poly (ADP-ribose) polymerase (PARP) cleavage is a hallmark of caspase activation. PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a variety of cellular processes, including DNA repair, genomic stability, and programmed cell death. PARP enzymes play a crucial role in repairing single-strand breaks in DNA.
PARP has gained significant attention, particularly in the treatment of certain types of tumors, such as those with BRCA1 or BRCA2 mutations. These mutations impair the cell's ability to repair double-strand breaks in DNA through homologous recombination. Cancer cells with these mutations can become reliant on PARP for survival, making them particularly sensitive to PARP inhibitors.
PARP inhibitors, such as olaparib, rucaparib, and niraparib, have been developed as targeted therapies for cancers associated with BRCA mutations.

PARP Family:
The poly (ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death.
PARP1 is the predominant family member responsible for detecting DNA strand breaks and initiating repair processes, especially through base excision repair (BER).

PARP1 Overexpression:
In several cancer types—including breast, ovarian, prostate, and lung cancers—elevated PARP1 expression and/or activity has been reported.
High PARP1 expression in certain cancers has been associated with aggressive tumor behavior and resistance to therapies (especially those that induce DNA damage).
Increased PARP1 activity may correlate with poorer overall survival in tumors that rely on DNA repair for survival.
Scientific Papers found: Click to Expand⟱
233- AL,  5-FU,    Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway
- in-vivo, Liver, NA
ROS↑, MMP↓, Casp3↑, PARP↑, Bcl-2↓,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1↓, cycE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
586- Api,  5-FU,    5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma
- in-vivo, HCC, NA
ROS↑, MMP↓, Bcl-2↓, Casp3↑, PARP↑,
242- Api,    Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, C8161
ERK↓, PI3k/Akt/mTOR↓, Casp3↑, PARP↑, p‑mTOR↓, p‑Akt↓,
243- Api,    Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
p‑FAK↓, ERK↓, Casp3↑, PARP↑, ITGA5↓, NA↓,
268- Api,    Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
- in-vitro, AML, HL-60
Casp3↑, PARP↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
2600- Ba,    Baicalein Induces Apoptosis and Autophagy via Endoplasmic Reticulum Stress in Hepatocellular Carcinoma Cells
- in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402
ER Stress↑, Bcl-2↓, Ca+2↑, JNK↑, CHOP↑, Casp9↑, Casp3↑, PARP↑, Apoptosis↑, UPR↑,
2023- BBR,    Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
- in-vitro, Colon, NA - in-vitro, Nor, YAMC
TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
2754- BetA,    Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
- in-vitro, Pca, LNCaP
VEGF↓, survivin↓, Sp1/3/4↓, Casp↑, PARP↑, survivin↓, angioG↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1↓, hTERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑,
118- CUR,    Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB↓, MDM2↓,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓,
689- EGCG,    EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9
- vitro+vivo, Bladder, SW780
Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27↑, P21↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
1155- F,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
1966- GamB,  Cisplatin,    Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
- in-vitro, Lung, A549 - in-vitro, Lung, NCIH1299
TumCCA↑, PARP↑, eff↑, ROS↑, ChemoSen↑,
820- GAR,    Garcinol in gastrointestinal cancer prevention: recent advances and future prospects
- Review, NA, NA
Fas↑, TRAIL↑, PARP↑, BAX↑, Bcl-2↓, ROS↑, STAT3↓, Apoptosis↑, MMP2↓, MMP9↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, AMPK↑, mTOR↑, P53↑, H2O2↑, ROS↑, toxicity↝, p62↓, DR5↑, Casp8↑, PARP↑, cl‑Casp3↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB↓, cycA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- in-vitro, Pca, NA
CycB↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓,
71- QC,    Role of Bax in quercetin-induced apoptosis in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PrEC - in-vitro, Pca, YPEN-1 - in-vitro, Pca, HCT116
Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓,
41- QC,    Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
- vitro+vivo, AML, HL-60
Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, PARP↑, MMP↓,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
4468- VitC,  Se,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, NA, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 38

Results for Effect on Cancer/Diseased Cells:
AIF↑,1,   Akt↓,6,   p‑Akt↓,5,   ALAT↓,2,   ALP↓,1,   AMPK↑,1,   angioG↓,3,   AP-1↓,1,   APAF1↑,1,   Apoptosis↑,9,   AR↓,2,   ASC↓,1,   AST↓,1,   ATF3↑,1,   ATF4↑,2,   ATG3↑,1,   ATG5↑,1,   ATP↓,3,   AXL↓,1,   BAD↓,2,   BAD↑,2,   Bak↑,3,   BAX↓,1,   BAX↑,9,   Bax:Bcl2↑,1,   Bcl-2↓,13,   Bcl-xL↓,3,   Beclin-1↓,1,   Beclin-1↑,3,   BID↑,2,   BioAv↑,3,   BioAv↝,1,   Ca+2↑,3,   cachexia↓,1,   cardioP↑,1,   Casp↑,3,   Casp1↓,1,   Casp3↑,20,   cl‑Casp3↑,2,   Casp7↑,3,   Casp8↓,1,   Casp8↑,9,   Casp9↑,11,   cl‑Casp9↑,1,   Catalase↓,2,   CD34↓,1,   CDC2↓,2,   cDC2↓,1,   CDC25↓,1,   Cdc42↓,1,   CDK1↓,4,   CDK2↓,3,   CDK4↓,5,   CDK6↓,1,   CDK6↑,1,   CEA↓,1,   cFLIP↓,1,   cFos↑,1,   chemoP↑,2,   ChemoSen↑,4,   CHK1↓,1,   Chk2↓,1,   CHOP↑,4,   CK2↓,1,   CLDN1↓,2,   cMyc↓,1,   COX2↓,3,   COX2↑,1,   CSCs↓,1,   cycA1↓,2,   CycB↓,4,   cycD1↓,2,   cycE↓,2,   CYP1A1↓,1,   Cyt‑c↑,5,   DNAdam↑,8,   DNMTs↓,1,   DR5↑,4,   E-cadherin↓,2,   E-cadherin↑,1,   E6↓,1,   E7↓,1,   eff↓,4,   eff↑,9,   EGFR↓,5,   EGFR↑,1,   p‑eIF2α↑,2,   EM↑,1,   EMT↓,7,   ER Stress↑,5,   ER-α36↓,1,   ERK↓,5,   ERK↑,3,   FAK↓,1,   p‑FAK↓,1,   Fas↑,6,   FasL↑,2,   Fenton↑,2,   FGF↓,2,   FGFR1↓,2,   FGFR2↓,1,   Fibronectin↓,1,   FOXO3↑,1,   GAPDH↓,1,   GlutMet↓,1,   Glycolysis↓,1,   GPx↓,2,   GRP78/BiP↑,2,   GSH↓,2,   GSR↓,1,   GSR↑,1,   GSTs↓,1,   H2O2↑,2,   H3↓,1,   H3↑,1,   H4↓,1,   HATs↓,1,   HDAC↓,3,   HER2/EBBR2↓,1,   HEY1↓,1,   HGF/c-Met↓,3,   Hif1a↓,2,   HK2↓,1,   HO-1↓,2,   HO-1↑,1,   HSP90↓,1,   hTERT↓,1,   ICAM-1↓,1,   IGF-1R↑,1,   IKKα↓,1,   IL10↓,1,   IL1β↓,1,   IL2↑,1,   IL6↓,2,   IM↓,1,   iNOS↓,1,   ITGA5↓,1,   ITGB1↓,1,   IκB↓,1,   JNK↑,3,   p‑JNK↑,1,   Ki-67↓,2,   lactateProd↓,1,   LC3‑Ⅱ/LC3‑Ⅰ↓,1,   LC3‑Ⅱ/LC3‑Ⅰ↑,1,   LC3B↑,1,   LC3II↓,1,   LC3II↑,2,   LDH↓,1,   LDHA↓,1,   LDL↓,1,   lipid-P↑,4,   MAPK↓,4,   MAPK↑,3,   Mcl-1↓,4,   MDM2↓,1,   p‑MDM2↓,1,   MET↓,1,   p‑MET↓,1,   miR-27a-3p↓,1,   mitResp↓,1,   MMP↓,6,   MMP↑,2,   MMP-10↓,1,   MMP2↓,7,   MMP9↓,8,   MMPs↓,2,   mtDam↑,1,   mTOR↓,3,   mTOR↑,1,   p‑mTOR↓,2,   Myc↓,1,   N-cadherin↓,2,   NA↓,1,   NAD↓,2,   NADPH↑,1,   necrosis↑,1,   neuroP↑,2,   NF-kB↓,6,   NLRP3↓,1,   NOTCH↓,1,   NOTCH1↓,1,   NOTCH1↑,1,   NOTCH3↓,1,   NOXA↑,1,   NQO1↓,1,   NQO1↑,1,   NRF2↓,2,   NRF2↑,1,   NSE↓,1,   other↝,1,   P21↑,5,   p27↑,1,   p38↑,2,   p‑p38↑,2,   P53↑,6,   p62↓,2,   p‑p65↓,1,   p‑P70S6K↓,1,   PARP↑,37,   PCNA↓,2,   PD-1↓,1,   PDGF↓,1,   PDGFR-BB↓,1,   PDK1↓,1,   PGE2↓,1,   PI3K↓,4,   p‑PI3K↓,1,   PI3K/Akt↓,2,   PI3k/Akt/mTOR↓,1,   PPARα↓,1,   PSA↓,1,   PTEN↓,1,   PTEN↑,2,   PUMA↑,1,   Rac1↓,1,   RadioS↑,2,   p‑RB1↓,1,   RenoP↑,2,   Rho↓,1,   ROS↑,19,   ROS⇅,2,   RTK-RAS↓,1,   SCF↓,1,   selectivity↑,4,   Shh↓,1,   SIRT1↓,1,   SIRT3↑,1,   Slug↓,3,   Snail↓,4,   SOD↓,2,   SOD2↓,1,   Sp1/3/4↓,2,   p‑Src↓,1,   STAT3↓,6,   p‑STAT3↓,1,   p‑STAT6↓,1,   survivin↓,4,   Telomerase↓,1,   TET1↑,1,   TGF-β↓,2,   TIMP1↑,2,   TLR4↓,1,   TNF-α↓,2,   TOP1↓,1,   toxicity↝,1,   TP53↓,1,   TRAIL↑,1,   TumAuto↑,2,   TumCCA↑,6,   TumCD↑,3,   TumCG↓,1,   TumCMig↓,1,   TumCP↓,4,   tumCV↓,3,   TumVol↓,1,   TumW↓,1,   Twist↓,2,   Tyro3↓,1,   tyrosinase↓,1,   uPA↓,2,   UPR↑,3,   VEGF↓,9,   Vim↓,3,   Vim↑,1,   VitC↓,1,   VitE↓,1,   Warburg↓,1,   Wnt↑,1,   Wnt/(β-catenin)↓,1,   XBP-1↓,1,   XIAP↓,3,   ZBTB10↑,1,   Zeb1↑,1,   ZO-1↑,1,   β-catenin/ZEB1↓,2,   γH2AX↑,2,  
Total Targets: 277

Results for Effect on Normal Cells:
AntiCan↑,1,   antiOx↑,1,   AP-1↓,1,   AST↓,1,   BAX↓,1,   BBB↑,1,   BioAv↓,3,   BioAv↑,1,   BioAv↝,1,   Ca+2?,1,   cardioP↑,2,   Casp3?,1,   Casp3↓,1,   cl‑Casp8↑,1,   Catalase↑,1,   COX2↓,2,   Cyt‑c↓,1,   Dose↝,1,   E2Fs↑,1,   eff↑,1,   glucose↓,1,   GPx↑,1,   GSH↑,1,   GSTs↑,1,   Half-Life↝,2,   hepatoP↓,1,   IGF-1R↓,1,   IL10↑,1,   IL1β↓,1,   IL6↓,1,   IL8↓,1,   Inflam↓,2,   iNOS↓,2,   JAK↓,1,   LDL↓,1,   lipid-P↓,1,   memory↑,1,   MMP∅,1,   MMP2↓,1,   MPO↓,1,   neuroP↑,2,   NF-kB↓,3,   NRF2↑,1,   other↓,1,   P21↑,1,   P53↓,1,   PARP↑,1,   PDGFR-BB↓,1,   Prx↑,1,   RNS↓,1,   ROS↓,2,   ROS∅,1,   SOD↑,1,   SOD1↑,1,   SOD2↑,2,   TNF-α↓,2,   toxicity↓,4,  
Total Targets: 57

Scientific Paper Hit Count for: PARP, poly ADP-ribose polymerase (PARP) cleavage
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
4 Apigenin (mainly Parsley)
4 Vitamin C (Ascorbic Acid)
3 Curcumin
2 Allicin (mainly Garlic)
2 5-fluorouracil
2 Berberine
2 Docetaxel
2 Garcinol
1 Ashwagandha
1 Baicalein
1 Betulinic acid
1 Chrysin
1 Fucoidan
1 Ferulic acid
1 Gambogic Acid
1 Cisplatin
1 Juglone
1 Luteolin
1 Magnolol
1 Piperlongumine
1 Resveratrol
1 Shikonin
1 Selenium
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:239  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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