Database Query Results : , , Prx

Prx, Peroxiredoxin: Click to Expand ⟱
Source:
Type:
also known as Prx
Peroxiredoxins are endogenous antioxidants and redox sensors. Properties of the peroxiredoxins make them suitable as markers of oxidative stress.
Peroxiredoxins (Prxs) are a family of antioxidant enzymes that play a crucial role in cellular redox signaling and the detoxification of reactive oxygen species (ROS). They are involved in various cellular processes, including cell proliferation, differentiation, and apoptosis.
Prx isoforms (such as Prx1 and Prx4) are often overexpressed. This overexpression can help cancer cells cope with increased levels of reactive oxygen species (ROS) generated during rapid cell division and metabolic changes.
Elevated Prx levels have been linked to resistance against chemotherapy and radiation therapy. For example, Prx2 and Prx3 have been implicated in protecting cancer cells from oxidative damage caused by these treatments.
Some Prxs, such as Prx3, can act as tumor suppressors. Their downregulation or loss of function has been associated with increased tumorigenesis and poor prognosis in certain cancers.

PRDX family comprises several isoforms (for example, PRDX1, PRDX2, PRDX3, etc.) that function as antioxidant enzymes to reduce reactive oxygen species (ROS) and maintain redox balance.

PRDX family—especially key isoforms like PRDX1 and PRDX2—are often upregulated in various cancers, correlating with worse prognosis and enhanced tumor cell survival. Through their ROS-detoxifying capabilities, these proteins generally play protumorigenic roles by protecting malignant cells from oxidative stress and supporting resistance to apoptosis and therapy.


Scientific Papers found: Click to Expand⟱
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   AP-1↓,1,   ATF3↑,1,   ATF4↑,1,   Bcl-2↓,1,   cl‑Casp3↑,1,   cl‑Casp9↑,1,   CDC2↓,1,   CDK1↓,1,   CDK2↓,1,   CDK4↓,2,   CHK1↓,1,   Chk2↓,1,   CHOP↑,1,   COX2↓,1,   CSCs↓,1,   cycA1↓,1,   CycB↓,1,   cycE↓,1,   Cyt‑c↑,1,   E6↓,1,   E7↓,1,   eff↑,3,   EMT↓,1,   ER Stress↑,1,   ER-α36↓,1,   FOXO3↑,1,   GSR↑,1,   H3↑,1,   HEY1↓,1,   HO-1↑,1,   HSP90↓,1,   LDHA↓,1,   lipid-P↑,1,   MAPK↑,1,   Mcl-1↓,1,   mitResp↓,1,   MMP↓,1,   MMP2↓,1,   MMP9↓,1,   MMPs↓,1,   N-cadherin↓,1,   NADPH↑,1,   NF-kB↓,1,   NOTCH↓,1,   NQO1↑,1,   NRF2↑,1,   other↑,1,   P21↑,1,   p38↑,1,   P53↑,1,   PARP↑,1,   PDGFR-BB↓,1,   p‑RB1↓,1,   RenoP↑,1,   ROS↑,1,   selectivity↑,1,   SIRT3↑,1,   Slug↓,1,   Snail↓,1,   STAT3↓,1,   TumCCA↑,1,   TumCD↑,1,   uPA↓,1,   VEGF↓,1,   Vim↓,1,   β-catenin/ZEB1↓,1,   γH2AX↑,1,  
Total Targets: 68

Results for Effect on Normal Cells:
antiOx↑,1,   AP-1↓,1,   ATP↑,2,   BioAv↑,1,   Casp3?,1,   Casp3↓,1,   Catalase↑,4,   cognitive↑,1,   COX1↓,1,   COX2↓,1,   CRP↓,1,   DNAdam↓,1,   eff↝,1,   ERK↑,1,   GABA↑,1,   GlucoseCon↓,1,   Glycolysis↝,1,   GPx↑,2,   GSH↓,1,   GSH↑,4,   GSR↑,1,   GutMicro↑,1,   HK2↓,1,   HO-1↑,3,   IL10↑,1,   IL1β↓,1,   IL4↑,1,   IL8↓,1,   Inflam↓,2,   iNOS↓,2,   lactateProd↓,1,   LDHA↓,1,   lipid-P↓,1,   LOX1↓,1,   MDA↓,3,   memory↑,2,   MMP↑,1,   MMP9↓,1,   MMPs↓,1,   NADPH↓,2,   neuroP↑,1,   NF-kB↓,1,   NRF2↑,2,   PFK2↓,1,   PPP↓,1,   Prx↑,6,   radioP↑,1,   ROS↓,6,   SOD↑,4,   SOD2↑,1,   TGF-β↓,1,   TLR4↓,1,   TNF-α↓,1,   toxicity↓,1,   Trx↑,2,   TXNIP↓,1,   α-SMA↓,1,  
Total Targets: 57

Scientific Paper Hit Count for: Prx, Peroxiredoxin
2 Ashwagandha
1 Radiotherapy/Radiation
1 Propolis -bee glue
1 Rosmarinic acid
1 Taurine
1 Thymoquinone
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:263  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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