Database Query Results : , , Cyc

Cyc, Cyclin: Click to Expand ⟱
Source:
Type:
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation.
Scientific Papers found: Click to Expand⟱
259- ALA,    Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
- in-vitro, Liver, HepG2 - in-vitro, Liver, FaO
Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB↓, CDK1↓, P21↑, PCNA↝, HDAC↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
709- Bor,    Cellular changes in boric acid-treated DU-145 prostate cancer cells
- in-vitro, Pca, DU145
Cyc↓, MAPK↓, TumCMig↓, LAMP2↓, p‑ERK⇅, TumCM/A↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27↑, P53↑, VEGF↓, MAPK↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Results for Effect on Cancer/Diseased Cells:
ACC↓,1,   Akt↓,1,   p‑Akt↓,1,   AMPK↑,1,   angioG↓,2,   AntiCan↑,1,   antiOx↑,1,   APAF1↑,1,   Apoptosis↑,3,   ATF4↑,1,   ATF6↑,1,   BAX↑,4,   Bax:Bcl2↑,1,   Bcl-2↓,5,   Bcl-xL↓,3,   BID↑,1,   BRAF↝,1,   Ca+2↑,1,   CAFs/TAFs↓,1,   Casp↑,1,   Casp3↑,2,   cl‑Casp3↑,1,   Casp8↑,1,   cl‑Casp8↑,1,   Casp9↑,2,   Catalase↓,1,   Catalase↑,1,   CD133↓,1,   CDK1↓,3,   CDK1↑,1,   CDK2↓,1,   CDK4/6↓,1,   ChemoSen↑,3,   CHOP↑,1,   Copper↑,1,   COX2↓,1,   CSCs↓,1,   Cyc↓,12,   CycB↓,1,   Cyt‑c↑,2,   Cyt‑c↝,1,   DNAdam↑,1,   DR5↑,1,   E-cadherin↑,1,   ECAR↓,1,   eff↑,2,   eIF2α↑,1,   p‑ERK↓,1,   p‑ERK⇅,1,   Gli1↓,1,   GLI2↓,1,   Glycolysis↓,1,   GPx↑,1,   GPx4↓,1,   GSH↓,2,   GSH↑,1,   HDAC↓,2,   HH↓,1,   HIF-1↓,1,   HO-1↓,1,   IGF-1↓,2,   IL1↓,1,   IL6↓,1,   Inflam↓,1,   IRE1↑,1,   JNK↑,1,   lactateProd↓,1,   LAMP2↓,1,   LC3A↑,1,   lipid-P↑,1,   MAPK↓,2,   MAPK↝,1,   Mcl-1↓,1,   MDA↑,1,   p‑MEK↓,1,   MMP↓,2,   MMP2↓,2,   MMP9↓,2,   MMPs↓,1,   p‑mTOR↓,1,   N-cadherin↓,1,   n-MYC↓,1,   NAD↝,1,   NCAM↓,1,   Nestin↓,1,   neuroP↑,1,   NF-kB↓,3,   NOTCH2↓,1,   NRF2↓,1,   NRF2↑,2,   OCR↑,1,   other↓,1,   P21↓,1,   P21↑,5,   p27↑,2,   P53↑,3,   p‑P53↑,1,   p62↓,1,   cl‑PARP↑,2,   PCNA↝,1,   PD-L1↓,1,   PERK↑,1,   PI3K/Akt↝,1,   PSA↓,2,   PTEN↑,1,   PTEN↝,1,   RadioS↑,2,   Risk↓,1,   ROCK1↓,1,   ROS↑,5,   SAM-e↝,1,   selectivity↑,1,   Sharpin↓,1,   Shh↓,1,   Smo↓,1,   Snail↓,2,   SOD↓,1,   SOD↑,1,   SOX2↓,1,   Sp1/3/4↓,1,   Sufu↑,1,   survivin↓,3,   TNF-α↓,1,   TOP1↓,1,   TumCCA↑,6,   TumCG↓,2,   TumCI↓,1,   TumCM/A↑,1,   TumCMig↓,2,   TumCP↓,3,   TumVol↓,1,   Twist↓,1,   VEGF↓,3,   Vim↓,2,   Warburg↓,1,   XIAP↓,1,   β-catenin/ZEB1↓,1,  
Total Targets: 137

Results for Effect on Normal Cells:
ATP↝,1,   BioAv↓,1,   BMD↑,1,   BMPs↑,1,   Ca+2↝,1,   Calcium↑,1,   Catalase↑,1,   chemoP↑,1,   ChemoSideEff↓,1,   cognitive↑,1,   Dose↑,1,   Dose↝,1,   eff↑,1,   GPx↑,1,   hs-CRP↓,1,   HSP70/HSPA5↑,1,   Inflam↓,1,   LAMs↑,1,   Mag↑,1,   memory↑,1,   NAD↝,1,   neuroP↑,1,   Risk↓,1,   SAM-e↑,1,   selectivity↑,1,   serineP↓,1,   Smad1↑,1,   SOD↑,1,   testos↑,1,   TNF-α↓,1,   toxicity↓,1,   VitD↑,1,  
Total Targets: 32

Scientific Paper Hit Count for: Cyc, Cyclin
3 Boron
2 Apigenin (mainly Parsley)
1 Alpha-Lipoic-Acid
1 Cisplatin
1 Baicalein
1 Berberine
1 Betulinic acid
1 Graviola
1 Hydroxycinnamic-acid
1 Methylene blue
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:374  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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