Database Query Results : , , cycE

cycE, Cyclin E: Click to Expand ⟱
Source:
Type:
Cyclin E regulates multiple downstream molecules, such as the retinoblastoma susceptibility gene (RB1) and the transcription factor E2F.
Cyclin E is a prognostic marker in breast cancer, its altered expression increased with the increasing stage and grade of the tumor.
Cyclin E is a regulatory protein that plays a critical role in the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression levels can significantly influence cancer progression and patient prognosis.

Cyclin E expression is frequently elevated in various cancers and is generally associated with poor prognosis. Its role in promoting cell cycle progression makes it a potential biomarker for tumor aggressiveness and patient outcomes.


Scientific Papers found: Click to Expand⟱
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1↓, cycE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1↓, cycE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,
207- Api,    Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells
- in-vitro, Pca, LNCaP
PSA↓, cycD1↓, cycE↓, CDK2↓, CDK4/6↓, P21↑, AR↓,
314- Api,    Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
- in-vitro, SCC, HaCaT - in-vitro, SCC, SCC25
TumCCA↑, cycD1↓, cycE↓, CDK1/2/5/9∅,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB↓, NF-kB↓, cycD1↓, cycE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1↓, cycE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1↓, cycE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
1427- Bos,    Acetyl-keto-β-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, CRC, LS174T
TumCG↓, TumCCA↑, cycD1↓, cycE↓, CDK2↓, CDK4↓, p‑RB1↓, P21↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1↓, cycE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoP↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1↓, cycE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2↓, angioG↓,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27↑, cycA1↓, cycE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
1655- FA,    Ferulic acid inhibiting colon cancer cells at different Duke’s stages
- in-vitro, Colon, SW480 - in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCCA↑, Apoptosis↑, ATM↑, Chk2↑, ATR↑, CHK1↑, CK2↓, cycA1↑, CDK4↓, CDK6↓, cycD1↓, cycE↓, P53↑, P21↑,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1↓, cycE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE↓, cycD1↓, P21↑, COX2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27↑, cycD1↓, cycE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1↓, cycE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2928- LT,    Luteolin-mediated increase in miR-26a inhibits prostate cancer cell growth and induces cell cycle arrest targeting EZH2
EZH2↓, cycD1↓, cycE↓, CDK4↓, CDK6↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1↓, cycE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2↓, lipid-P↓, GSH↑, NRF2↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1↓, CycB↓, cycE↓, CDK2↓, CDK4↓, p27↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7
TumCCA↑, Apoptosis↑, eff↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1↓, cycE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE↓, *cycD1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1↓, CycB↓, cycE↓, cycD1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1↓, cycE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
cycD1↓, cycE↓, E2Fs↓, CycB↑, Casp↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE↓, cycD1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP↑,
3029- RosA,    Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1↓, cycE↓, P21↑, DNAdam↑, Casp3↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE↓, P21↑, p27↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27↑, cycE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1↓, cycE↓,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1↓, cycE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
3415- TQ,    The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations
- in-vitro, Lung, H446
tumCV↓, TumCCA↑, ROS↓, CycB↑, CycD3↑, cycA1↓, cycE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↑,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1↓, cycD1↓, cycE↓, CDK2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 43

Results for Effect on Cancer/Diseased Cells:
5HT↓,1,   5LO↓,1,   ADAM17↓,1,   ADP:ATP↑,1,   AIF↑,3,   Akt↓,14,   Akt↑,1,   p‑Akt↓,1,   AKT1↓,1,   AMP↓,1,   AMPK↑,3,   AMPK↝,1,   angioG↓,11,   AntiCan↑,3,   antiOx↓,1,   antiOx↑,3,   AP-1↓,5,   Apoptosis↑,10,   AR↓,3,   ARE/EpRE↑,1,   ascitic↓,1,   ATF3↑,1,   ATF4↑,4,   ATFs↑,1,   ATM↑,1,   ATP↓,1,   ATR↑,1,   AXL↓,1,   Bak↑,1,   BAX↓,1,   BAX↑,10,   BAX⇅,1,   Bax:Bcl2↑,4,   Bcl-2↓,9,   Bcl-2↑,1,   Bcl-xL↓,2,   BCR↓,1,   Beclin-1↑,1,   BID↑,1,   BIM↑,1,   BioAv↓,6,   BioAv↑,5,   BRCA1↑,1,   Ca+2↑,5,   Ca+2↝,1,   CAFs/TAFs↓,1,   Casp↑,5,   Casp↝,1,   Casp3↓,1,   Casp3↑,18,   cl‑Casp3↑,3,   Casp7↑,1,   cl‑Casp7↑,1,   Casp8↑,9,   cl‑Casp8↑,1,   Casp9↑,14,   cl‑Casp9↑,3,   proCasp9↓,1,   Catalase↑,1,   CBP↑,1,   CCR7↓,1,   CD133↓,1,   CD44↓,1,   CDC16↓,1,   CDC2↓,2,   cDC2↓,2,   CDC25↓,2,   Cdc42↑,1,   CDC7↓,1,   CDK1↓,2,   CDK1/2/5/9∅,1,   CDK2↓,25,   p‑CDK2↓,1,   CDK4↓,23,   CDK4/6↓,2,   CDK6↓,11,   CDK6↑,1,   CDK8↓,1,   cFLIP↓,1,   cFos↓,3,   chemoP↑,2,   ChemoSen↑,12,   CHK1↓,2,   CHK1↑,1,   Chk2↓,2,   Chk2↑,1,   CHOP↑,3,   cJun↓,3,   CK2↓,1,   cMyc↓,7,   COX1↓,1,   COX2↓,18,   CSCs↓,2,   CUL4B↑,1,   CXCR4↓,4,   cycA1↓,6,   cycA1↑,1,   CycB↓,5,   CycB↑,2,   cycD1↓,34,   CycD3↑,1,   cycE↓,42,   cycF↓,1,   CYP1A1↓,1,   Cyt‑c↑,16,   Diablo↑,6,   Diff↓,1,   DNAdam↓,2,   DNAdam↑,8,   DNMTs↓,1,   Dose?,1,   Dose↓,1,   Dose↑,2,   Dose↝,3,   Dose∅,1,   DR4↑,1,   DR5↓,1,   DR5↑,3,   E-cadherin↓,1,   E-cadherin↑,5,   E2Fs↓,3,   E6↓,1,   E7↓,1,   ECAR↝,1,   eff↓,4,   eff↑,30,   eff↝,3,   EGF↓,1,   EGFR↓,10,   p‑eIF2α↑,1,   EMT↓,8,   Endoglin↑,1,   EP300↑,1,   ER Stress↓,1,   ER Stress↑,9,   ER-α36↓,1,   ERK↓,6,   p‑ERK↓,2,   EZH2↓,2,   FADD↑,1,   FAK↓,1,   p‑FAK↓,1,   Fas↑,5,   FASN↓,1,   FOXO↑,1,   FOXO3↑,1,   Gli1↓,1,   GlucoseCon↓,2,   GLUT1↓,1,   Glycolysis↓,3,   GPx↑,2,   GRP78/BiP↓,1,   GRP78/BiP↑,6,   GSH↓,1,   GSH↑,3,   GSK‐3β↓,1,   GSR↑,2,   GSTA1↑,1,   GSTs↑,1,   GSTs↝,1,   GutMicro↑,1,   H2O2↑,1,   H3↑,1,   Half-Life↓,2,   Half-Life↝,1,   HATs↓,1,   HDAC↓,1,   HDAC1↓,1,   HDAC2↓,2,   hepatoP↑,1,   HER2/EBBR2↓,1,   HEY1↓,1,   HGF/c-Met↓,1,   HH↓,1,   Hif1a↓,7,   HO-1↓,1,   HO-1↑,2,   HO-2↓,1,   HSF1↓,1,   HSP27↓,1,   HSP27↝,1,   HSP70/HSPA5↓,3,   HSP70/HSPA5↝,1,   HSP90↓,3,   IFN-γ↓,1,   IGF-1↓,2,   IKKα↓,3,   IL1↓,1,   IL1↑,1,   IL12↓,1,   IL1α↓,1,   IL1β↓,2,   IL2↑,1,   IL4↓,1,   IL4↑,1,   IL6↓,5,   IL8↓,1,   Inflam↓,5,   iNOS↓,3,   IRE1↑,3,   JAK↓,1,   JAK1?,1,   JAK1↓,1,   p‑JAK1↓,1,   JAK2↓,1,   p‑JAK2↓,2,   JNK↓,2,   JNK↑,3,   Keap1↓,1,   Ki-67↓,2,   lactateProd↓,2,   LDHA↓,1,   Let-7↑,1,   lipid-P?,1,   lipid-P↓,2,   lipid-P↑,1,   LOX1↓,1,   M2 MC↓,1,   MAPK↓,2,   MAPK↑,2,   Mcl-1↓,8,   MCP1↓,2,   MDM2↓,3,   MDM2↑,1,   MEK↓,1,   MIP2↓,1,   miR-200b↑,1,   mitResp↓,1,   MMP↓,11,   MMP1↓,2,   MMP2↓,15,   MMP3↓,1,   MMP7↓,4,   MMP9↓,17,   MMP9↑,1,   MMPs↓,3,   MPO↓,1,   MSH2↑,1,   mtDam↑,1,   mTOR↓,10,   mTOR↝,1,   p‑mTOR↓,1,   mTORC1↓,3,   p‑mTORC1↓,1,   mTORC2↓,1,   mTORC2↑,1,   Myc↓,1,   N-cadherin↓,4,   n-MYC↓,1,   NADPH↓,1,   NADPH↑,1,   Nestin↓,1,   NF-kB↓,18,   NF2↑,1,   NHE1↓,1,   NO↓,1,   NO↑,1,   NOTCH↓,3,   NOTCH1↓,1,   NOXA↑,1,   NQO1↑,1,   NRF2↓,2,   NRF2↑,3,   P-gp↓,1,   p16↑,1,   P21?,1,   P21↑,24,   p27↓,1,   p27↑,12,   p38↑,4,   P450↝,1,   p50↓,1,   P53?,1,   P53↓,1,   P53↑,15,   p65↓,1,   p70S6↓,1,   PAK1↓,1,   PARP↓,1,   PARP↑,2,   cl‑PARP↓,1,   cl‑PARP↑,11,   PCNA↓,8,   PD-L1↓,1,   PDGF↓,2,   PDGFR-BB↓,1,   p‑PDGFR-BB↓,1,   PDK1?,2,   PGE2↓,7,   PI3K↓,10,   PI3K/Akt↓,1,   PKCδ↓,2,   PKM2↓,1,   PPARα↓,1,   cl‑PPARα↓,1,   PPARγ↑,2,   pRB↑,1,   p‑pRB↓,1,   PSA↓,2,   PTEN↓,1,   PTEN↑,4,   PUMA↑,2,   RadioS↑,7,   Raf↓,2,   RB1↑,2,   p‑RB1↓,5,   RenoP↑,1,   Risk↓,1,   ROS↓,6,   ROS↑,18,   p‑S6K↓,1,   selectivity↑,6,   SIRT1↓,1,   SIRT1↑,2,   SIRT3↑,2,   SIRT6↑,1,   Slug↓,2,   SMAD3↓,1,   Snail?,1,   Snail↓,4,   SOD↑,2,   SOD2↑,1,   SOX2↓,1,   STAT3↓,7,   p‑STAT3↓,4,   survivin↓,10,   TCF-4↓,2,   Telomerase↓,4,   Tf↓,1,   TGF-β↓,4,   TGFβR1↑,1,   TIMP1↑,1,   TIMP2↑,2,   TNF-α↓,5,   TNF-α↑,1,   TOP1↓,2,   TOP2↓,2,   TOP2↑,1,   toxicity↓,2,   TRAIL↑,1,   TS↓,1,   TSC1↑,1,   TSC2↑,2,   TumAuto↑,1,   TumCA↓,1,   TumCCA↓,1,   TumCCA↑,29,   TumCD↑,1,   TumCG↓,5,   TumCI↓,6,   TumCMig↓,7,   TumCP↓,10,   tumCV↓,8,   TumMeta↓,6,   TumMeta↑,1,   TumVol↓,1,   Twist↓,4,   uPA↓,8,   VCAM-1↓,1,   VEGF↓,11,   VEGFR2↓,2,   Vim↓,5,   Wnt↓,6,   Wnt/(β-catenin)↓,1,   XIAP↓,6,   Zeb1↓,2,   ZEB2↓,1,   β-catenin/ZEB1↓,7,   γH2AX↓,1,   γH2AX↑,1,  
Total Targets: 370

Results for Effect on Normal Cells:
AntiAg↑,2,   antiOx↓,1,   antiOx↑,6,   BioAv↓,2,   BioAv↑,1,   Ca+2↝,1,   cardioP↑,4,   Casp3?,1,   CDK2↓,1,   CDK4↓,1,   p‑cMyc↑,1,   COX2↓,1,   CREB↑,1,   cycD1↓,1,   cycE↓,1,   ERK↑,2,   FASN↓,1,   GABA↑,1,   GPx↑,1,   GSH↑,3,   GSR↑,1,   H2O2↓,1,   hepatoP↑,1,   HO-1↑,1,   IGF-1↑,1,   IL6↓,1,   IL8↓,1,   Inflam↓,7,   iNOS↓,1,   IronCh↓,1,   lipid-P↓,2,   MAPK↑,1,   MDA↓,1,   memory↑,1,   neuroP↑,3,   NF-kB↓,1,   NRF2↑,2,   PCNA↓,1,   Prx↑,1,   RB1↓,1,   ROS↓,4,   SOD↑,1,   SOD2↑,1,   TNF-α↓,1,   toxicity↓,4,   toxicity↑,1,  
Total Targets: 46

Scientific Paper Hit Count for: cycE, Cyclin E
6 Fisetin
4 Quercetin
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Berberine
2 Boswellia (frankincense)
2 Lycopene
2 Rosmarinic acid
2 Shikonin
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Andrographis
1 Gemcitabine (Gemzar)
1 Ashwagandha
1 Deguelin
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Ferulic acid
1 Gallic acid
1 Honokiol
1 Luteolin
1 Magnolol
1 Magnetic Fields
1 Chemotherapy
1 Propolis -bee glue
1 Pterostilbene
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:378  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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