Database Query Results : , , CycB

CycB, Cyclin B: Click to Expand ⟱
Source:
Type:
When cyclin B levels are elevated, cells can enter M phase prematurely and strict control over cell division is lost, which is favorable for cancer development.
Cyclin B is a regulatory protein that plays a crucial role in cell cycle progression, particularly in the transition from the G2 phase to mitosis. Its expression levels can significantly impact cancer progression and patient prognosis.
Cyclin B expression is often elevated in various cancers and is generally associated with poor prognosis.
Scientific Papers found: Click to Expand⟱
251- AL,    Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
Apoptosis↑, P53↑, P21↑, CHK1↑, CycB↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB↓, HH↓, Smo↓, Gli1↓,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB↓, CDK1↓, P21↑, PCNA↝, HDAC↓,
173- Api,    Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
- in-vitro, Colon, HCT116
CycB↓, cDC2↓, CDC25↓, P53↑, P21↑, cl‑PARP↑, proCasp8↓, proCasp9↓, proCasp3↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB↓, cycA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB↓, NF-kB↓, cycD1↓, cycE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB↓, cycD1↓, cycA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1↓, CycB↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB↓, cycA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB↓, cycD1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
118- CUR,    Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
ROS↑, Bcl-2↓, PARP↑, cDC2↓, CycB↓, MDM2↓,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1↓, CycB↓, p‑cJun↑,
863- Lae,    Amygdalin inhibits the growth of renal cell carcinoma cells in vitro
- in-vitro, RCC, NA
TumCG↓, TumCP↓, TumCCA↑, CDK1↓, CycB↓, E-cadherin↝, N-cadherin↝,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1↓, CycB↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1↓, CycB↓, cycE↓, CDK2↓, CDK4↓, p27↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB↓, cycA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1↓, CDK4↓, CycB↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
496- MF,    Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, ZR-75-1 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB↓, TumCCA↑, p‑Akt↓, p‑Akt↓,
2069- PB,    Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes
- in-vitro, Tong, NA
TumCG↓, ROS↑, P21↑, CycB↓, cDC2↓, CDC25↓, eff↓, TumCCA↑, Apoptosis↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1↓, CycB↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1↓, CycB↓, CDK2↓, P21↑, p27↑, hTERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
3256- PBG,    Mechanisms of Apoptosis and Cell Cycle Arrest Induced by Propolis in Cancer Therapy
- Review, Var, NA
TumCCA↑, CDK2↓, CDK4↓, cycA1↓, CycB↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB↓, cycD1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, NA↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1↓, CycB↓, cycE↓, cycD1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- in-vitro, Pca, NA
CycB↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓,
49- QC,    Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells
- in-vitro, Lung, A549
CDK1↓, CycB↓, PPARγ↑,
84- QC,    Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
- in-vitro, Pca, PC3
P21↑, cDC2↓, CDK1↓, CycB↓, Casp3↑, Bcl-2↓, Bcl-xL↓, BAX↑, pRB↓,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27↑, CycB↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4↑, CHOP↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, Foxm1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 41

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   ADP:ATP↑,1,   AEG1↓,1,   Akt↓,15,   Akt↑,1,   p‑Akt↓,6,   AMPK↑,2,   angioG↓,10,   AntiCan↑,4,   antiOx↓,1,   AntiTum↑,1,   AP-1↓,3,   APAF1↑,2,   Apoptosis↓,1,   Apoptosis↑,16,   AR↓,2,   ATF3↑,1,   ATF4↑,2,   ATM↑,1,   mt-ATP↓,1,   BAD↓,1,   Bak↑,1,   BAX↓,2,   BAX↑,15,   Bax:Bcl2↑,2,   BBB↑,1,   Bcl-2↓,14,   Bcl-2↑,1,   Bcl-xL↓,5,   Beclin-1↑,2,   BID↑,1,   BIM↑,1,   BioAv↓,6,   BioAv↑,4,   BioAv↝,1,   BNIP3↑,1,   BOK↑,1,   Ca+2↑,1,   i-Ca+2↑,1,   CAIX↑,1,   cardioP↑,2,   Casp↑,1,   Casp12↑,1,   Casp3↓,3,   Casp3↑,15,   cl‑Casp3↑,5,   proCasp3↓,1,   Casp7↑,3,   Casp8↑,7,   cl‑Casp8↑,3,   proCasp8↓,1,   pro‑Casp8↑,1,   Casp9↑,16,   cl‑Casp9↑,2,   proCasp9↓,2,   Catalase↓,1,   CD4+↓,1,   CD4+↑,1,   CD44↓,1,   CDC2↓,4,   cDC2↓,5,   CDC25↓,7,   Cdc42↑,1,   CDK1↓,15,   p‑CDK1↓,1,   CDK2↓,14,   CDK2↑,1,   CDK4↓,14,   CDK6↓,2,   cFLIP↓,1,   cFos↓,1,   chemoP↑,2,   ChemoSen↓,1,   ChemoSen↑,11,   ChemoSideEff↓,1,   CHK1↓,2,   CHK1↑,1,   Chk2↓,1,   Chk2↑,2,   CHOP↑,5,   p‑cJun↑,1,   CLDN2↓,1,   cMET↓,1,   cMyc↓,8,   p‑cMyc↑,1,   COX2↓,11,   COX2↑,1,   CRP↓,1,   CSCs↓,3,   CXCR4↓,3,   Cyc↓,1,   cycA1↓,10,   cycA1↑,2,   CycB↓,41,   cycD1↓,12,   cycE↓,5,   cycE1↓,1,   Cyt‑c↑,11,   Diablo↑,1,   DNAdam↑,5,   DNArepair↑,1,   Dose?,1,   Dose↝,1,   Dose∅,1,   DR5↓,1,   DR5↑,5,   E-cadherin↑,7,   E-cadherin↝,1,   E2Fs↓,1,   E6↓,1,   E7↓,1,   eff↓,5,   eff↑,21,   eff↝,1,   EGF↓,1,   EGFR↓,3,   p‑EGFR↓,1,   eIF2α↑,1,   p‑eIF2α↑,2,   EMT↓,9,   EMT↑,1,   EP4↑,1,   ER Stress↓,1,   ER Stress↑,7,   ER-α36↓,1,   ER(estro)↓,1,   ERK↓,6,   ERK↑,1,   p‑ERK↓,3,   FADD↑,2,   FAK↓,3,   p‑FAK↓,2,   Fas↑,5,   FasL↑,4,   FGF↓,1,   FGFR1↓,1,   Foxm1↓,1,   FOXO3↓,1,   FOXO3↑,1,   p‑FOXO3↓,1,   FOXP3↓,1,   Gli1↓,1,   GlucoseCon↓,1,   GLUT1↓,2,   GLUT1↑,1,   GLUT3↑,1,   Glycolysis↓,2,   GRP78/BiP↑,3,   GSH↓,3,   GSH↑,2,   GSK‐3β↓,2,   GSK‐3β↑,2,   p‑GSK‐3β↓,1,   GSR↑,1,   GSTs↑,1,   GutMicro↑,1,   H3↓,1,   H3↑,1,   Half-Life↓,2,   HDAC↓,2,   HDAC10↓,1,   HER2/EBBR2↓,2,   p‑HER2/EBBR2↓,1,   HEY1↓,1,   HH↓,1,   Hif1a↓,8,   HK2↓,3,   HO-1↓,1,   HO-1↑,3,   HSP70/HSPA5↓,3,   HSP90↓,3,   hTERT↓,3,   IAP1↓,1,   IFN-γ↓,1,   IGF-1↓,1,   IGF-1R↓,1,   IGFBP3↑,1,   Igs↑,1,   IKKα↓,3,   p‑IKKα↓,1,   IL1↓,2,   IL10↓,1,   IL12↓,1,   IL1α↓,1,   IL1β↓,5,   IL2↓,1,   IL2↑,1,   IL6↓,9,   IL8↓,4,   Inflam↓,2,   iNOS↓,1,   JAK1↓,1,   JAK2↓,1,   JNK↓,1,   JNK↑,2,   p‑JNK↓,1,   Ki-67↓,2,   KRAS↓,1,   lactateProd↓,1,   LC3‑Ⅱ/LC3‑Ⅰ↑,1,   LC3B-II↑,2,   LC3II↑,1,   LDH↑,1,   LDHA↓,2,   lipid-P↓,2,   lipid-P↑,3,   LOX1↓,1,   MAPK↓,4,   MAPK↑,4,   Mcl-1↓,5,   MCP1↓,1,   MDA↓,1,   MDA↑,1,   MDM2↓,7,   MDR1↓,1,   miR-21↑,1,   mitResp↓,1,   MMP↓,9,   MMP1↓,1,   MMP13↓,2,   MMP2↓,11,   MMP3↓,1,   MMP7↓,1,   MMP9↓,13,   MMP9↑,2,   MMPs↓,3,   MPO↓,1,   mtDam↑,1,   mTOR↓,9,   p‑mTOR↓,2,   N-cadherin↓,6,   N-cadherin↝,1,   NA↓,1,   NADPH↑,1,   NAIP↓,1,   Nanog↓,1,   NF-kB↓,16,   p‑NF-kB↑,1,   NICD↓,1,   NK cell↑,2,   NO↓,1,   NO↑,1,   NOTCH↓,3,   NOTCH1↓,1,   NOTCH1↑,1,   NQO1↑,2,   NRF2↓,4,   NRF2↑,4,   OCT4↓,1,   OS↑,1,   other↓,1,   P-gp↓,2,   P21↑,25,   p27↑,8,   p38↑,4,   p‑p38↓,1,   p‑p38↑,1,   p50↓,1,   P53↑,21,   p62↑,1,   P70S6K↓,1,   p‑P70S6K↓,2,   p‑P90RSK↑,1,   PARP↓,2,   PARP↑,3,   cl‑PARP↑,8,   PCNA↓,5,   PCNA↝,1,   PD-L1↓,2,   PDGF↓,1,   PDGFR-BB↓,1,   PDK1↓,2,   PDK3↑,1,   PERK↑,1,   PFK↓,1,   PGE2↓,2,   PI3K↓,13,   PKCδ↓,2,   PKM2↓,2,   PPARγ↑,1,   pRB↓,1,   p‑pRB↓,1,   PSA↓,1,   PTEN↓,1,   PTEN↑,1,   PUMA↑,2,   radioP↑,2,   RadioS↑,5,   Raf↓,2,   RANKL↓,1,   RAS↓,4,   RB1↓,1,   RB1↑,1,   p‑RB1↓,2,   RenoP↑,2,   Rho↓,2,   ROCK1↓,3,   ROS↓,5,   ROS↑,22,   ROS⇅,2,   ROS∅,1,   i-ROS↑,1,   p‑S6↓,1,   selectivity↑,5,   Shh↓,3,   SIRT3↑,1,   Slug↓,3,   Smo↓,1,   Snail↓,5,   SOD↓,1,   SOD↑,3,   SOD1↑,1,   SOD2↑,1,   SOX2↓,1,   Sp1/3/4↓,2,   STAT3↓,10,   p‑STAT3↓,1,   survivin↓,8,   T-Cell↑,1,   TAZ↓,1,   Telomerase↓,1,   TGF-β↓,3,   Th1 response↑,1,   TIMP1↑,1,   TIMP2↑,2,   TLR4↓,2,   TNF-α↓,6,   TNF-α↑,2,   TOP1↓,1,   TOP2↓,3,   toxicity↓,1,   TRAIL↑,1,   Treg lymp↓,1,   Trx1↑,1,   TrxR↓,1,   TSP-1↑,1,   TumAuto↑,3,   TumCCA↑,28,   TumCD↑,2,   TumCG↓,5,   TumCG↑,1,   TumCI↓,4,   TumCMig↓,4,   TumCP↓,14,   tumCV↓,5,   TumMeta↓,6,   TumMeta↑,1,   TumVol↓,1,   TumW↓,1,   Twist↓,3,   uPA↓,5,   uPAR↓,1,   UPR↑,1,   VCAM-1↓,1,   VEGF↓,13,   VEGFR2↓,3,   Vim↓,6,   Warburg↓,1,   Wnt↓,3,   Wnt/(β-catenin)↓,2,   XIAP↓,3,   YAP/TEAD↓,1,   Zeb1↓,1,   α-tubulin↓,1,   β-catenin/ZEB1↓,2,   γH2AX↑,1,  
Total Targets: 366

Results for Effect on Normal Cells:
AChE↓,1,   Akt↓,1,   ALAT↓,1,   angioG↓,1,   AntiAg↑,2,   antiOx↑,8,   AST↓,1,   Aβ↓,2,   BBB↑,2,   BioAv↓,5,   BioAv↑,1,   BioAv↝,1,   BP↓,2,   cardioP↑,3,   Casp3?,1,   cl‑Casp8↑,1,   Catalase↑,5,   cognitive↑,1,   COX2↓,2,   creat↓,1,   eff↑,1,   FASN↓,1,   GPx↑,3,   GSH↑,5,   GSK‐3β↓,1,   GSR↑,1,   GSTs↑,2,   GutMicro↑,1,   H2S↑,1,   Half-Life↑,1,   Half-Life↝,1,   hepatoP↑,4,   HO-1↑,1,   IL10↓,1,   IL17↓,1,   IL1β↓,1,   IL6↓,2,   IL8↓,1,   Inflam↓,6,   iNOS↓,1,   IronCh↓,1,   IronCh↑,1,   Keap1↓,1,   LDH↓,2,   lipid-P↓,4,   MCP1↓,1,   MDA↓,3,   memory↑,1,   MMP↑,1,   MPO↓,1,   neuroP↑,5,   NF-kB↓,1,   NO↓,2,   Nrf1↑,1,   NRF2↑,4,   other↑,1,   P21↑,1,   Pain↓,1,   PARP↑,1,   PGE2↓,1,   PI3K↓,1,   Prx↑,1,   ROS↓,10,   SOD↑,5,   SOD2↑,1,   tau↓,1,   TBARS↓,1,   TNF-α↓,2,   toxicity↓,2,  
Total Targets: 69

Scientific Paper Hit Count for: CycB, Cyclin B
7 Quercetin
4 Propolis -bee glue
3 Apigenin (mainly Parsley)
2 Allicin (mainly Garlic)
2 Betulinic acid
2 Chrysin
2 Curcumin
2 Luteolin
2 Magnolol
2 Silymarin (Milk Thistle) silibinin
1 Andrographis
1 Artemisinin
1 Ashwagandha
1 Baicalein
1 Berberine
1 Emodin
1 Garcinol
1 Laetrile B17 Amygdalin
1 Melatonin
1 Magnetic Fields
1 Phenylbutyrate
1 Piperlongumine
1 Resveratrol
1 Sulforaphane (mainly Broccoli)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:379  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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