Database Query Results : , , Ca+2

Ca+2, Calcium Ion Ca+2: Click to Expand ⟱
Source:
Type:
In all eukaryotic cells, intracellular Ca2+ levels are maintained at low resting concentrations (approximately 100 nM) by the activity of the major Ca2+ extrusion system, the plasma membrane Ca2+-ATPase (PMCA), which exchanges extracellular protons (H+) for cytosolic Ca2+.
Indeed, sustained elevation of [Ca2+]C in the form of overload, saturating all Ca2+-dependent effectors, prolonged decrease in [Ca2+]ER, causing ER stress response, and high [Ca2+]M, inducing mitochondrial permeability transition (MPT), are considered to be pro-death factors.
In cancer the Ca2+-handling toolkit undergoes profound remodelling (figure 1) to favour activation of Ca2+-dependent transcription factors, such as the nuclear factor of activated T cells (NFAT), c-Myc, c-Jun, c-Fos that promote hypertrophic growth via induction of the expression of the G1 and G1/S phase transition cyclins (D and E) and associated cyclin-dependent kinases (CDK4 and CDK2).
Thus, cancer cells may evade apoptosis through decreasing calcium influx into the cytoplasm. This can be achieved by either downregulation of the expression of plasma membrane Ca2+-permeable ion channels or by reducing the effectiveness of the signalling pathways that activate these channels. Such protective measures would largely diminish the possibility of Ca2+ overload in response to pro-apoptotic stimuli, thereby impairing the effectiveness of mitochondrial and cytoplasmic apoptotic pathways.
Voltage-Gated Calcium Channels (VGCCs): Overexpression of VGCCs has been associated with increased tumor growth and metastasis in various cancers, including breast and prostate cancer.
Store-Operated Calcium Entry (SOCE): SOCE mechanisms, such as STIM1 and ORAI1, are often upregulated in cancer cells, contributing to enhanced cell survival and proliferation.
High intracellular calcium levels are associated with increased cell proliferation and migration, leading to a poorer prognosis. Calcium signaling can also influence hormone receptor status, affecting treatment responses.
Increased Ca²⁺ signaling is associated with advanced disease and metastasis. Patients with higher CaSR expression may have a worse prognosis due to enhanced tumor growth and resistance to apoptosis. -Ca2+ is an important regulator of the electric charge distribution of bio-membranes.
Scientific Papers found: Click to Expand⟱
2656- AL,    Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
- in-vitro, Park, PC12
*antiOx↑, *Apoptosis↓, *LDH↓, ROS↓, *lipid-P↓, *mtDam↓, *MMP↓, *Cyt‑c↓, *ATP∅, *Ca+2↝, *neuroP↑,
1098- BA,    Baicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2
- in-vitro, Nor, MCF10 - in-vivo, NA, NA
*TumCMig↓, *F-actin↓, *E-cadherin↑, *ZO-1↑, *N-cadherin↓, *Vim↓, *Snail↓, *cal2↓, *Ca+2↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1↓, cycE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoP↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1↓, cycE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
3203- EGCG,    (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
- NA, MM, NA
ROS↑, Ca+2↝, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP↑, Casp3↑, Casp8↑, *GRP78/BiP↓, *UPR↓, UPR↑,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,
3536- MF,    Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
- Review, Arthritis, NA - Review, Stroke, NA
*Inflam↓, *Diff↑, *toxicity∅, *other↑, *SOX9↑, *COL2A1↑, *NO↓, *PGE2↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *angioG↑, *MSCs↑, *VEGF↑, *TGF-β↑, *angioG↝, *VEGF↓, Ca+2↝,
3465- MF,    Magnetic fields and angiogenesis
- Review, Var, NA
angioG↓, *angioG↑, selectivity↑, Ca+2↝, ROS↝,
3812- mushLions,    Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *p‑tau↓, *ROS↓, *NRF2↓, *Ca+2↝,
2065- PB,  TMZ,    Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
- in-vitro, GBM, NA
eff↑, ROS↑, MMP↓, ER Stress↑, CHOP↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE↑, cycA1↑, TumCCA↑, cycD1↑, OXPHOS↑,
4357- RF,    Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies
- Review, Var, NA
other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,
4501- Se,    Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines
- in-vitro, GBM, A172 - in-vitro, Colon, Caco-2 - in-vitro, Pca, DU145 - in-vitro, BC, MCF-7 - in-vitro, Nor, L929
*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,
346- SNP,  RSQ,    Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment
- in-vivo, Melanoma, SK-MEL-28 - in-vivo, Melanoma, WM35
ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Results for Effect on Cancer/Diseased Cells:
5HT↓,1,   AIF↑,1,   Akt↓,2,   Akt↑,1,   p‑Akt↓,1,   angioG↓,5,   AntiCan↑,3,   antiOx↓,1,   AntiTum↑,1,   Apoptosis↑,3,   AR↓,1,   ascitic↓,1,   ATF4↑,1,   ATP↑,1,   BAX↑,1,   Bax:Bcl2↑,1,   Bcl-2↓,1,   Bcl-xL↓,1,   BIM↑,1,   BioAv↓,1,   BioAv↑,2,   Ca+2↝,10,   Casp10↑,1,   pro‑Casp12↓,1,   Casp3↑,5,   Casp8↑,4,   Casp9↑,3,   CD4+↑,1,   CD8+↑,1,   CDK2↓,2,   CDK4↓,1,   CDK6↓,2,   CDK8↓,1,   chemoP↑,2,   ChemoSen↑,2,   CHOP↑,3,   cMyc↓,2,   COL1↓,1,   COL3A1↓,1,   COX1↓,1,   COX2↓,3,   CSCs↓,1,   CXCR4↓,1,   Cyc↓,1,   cycA1↑,1,   cycD1↓,3,   cycD1↑,1,   cycE↓,2,   cycE↑,1,   Cyt‑c↑,1,   DFF45↑,1,   Diablo↑,1,   DNAdam↓,1,   Dose↑,1,   Dose↝,2,   Dose∅,1,   DR4↑,1,   DR5↑,3,   E-cadherin↓,1,   ECAR↓,1,   ECAR↝,1,   eff↓,1,   eff↑,11,   eff↝,2,   EGFR↓,2,   EMT↓,1,   Endoglin↑,1,   ER Stress↑,1,   p‑ERK↓,2,   p‑FAK↓,1,   Fas↑,1,   GADD34↑,1,   GlucoseCon↓,1,   Glycolysis↓,2,   GRP78/BiP↑,2,   GSH↓,1,   GSK‐3β↓,1,   Half-Life↓,1,   HDAC↓,1,   HIF-1↓,1,   Hif1a↓,1,   HO-1↓,1,   HO-1↑,1,   HO-2↓,1,   HSP27↓,1,   IFN-γ↓,1,   IGF-1↓,1,   IKKα↓,2,   IL1α↓,1,   IL6↓,1,   IL8↓,1,   Inflam↓,2,   iNOS↓,2,   JAK↓,1,   lactateProd↓,2,   LEF1↓,1,   Let-7↑,1,   lipid-P?,1,   Mcl-1↓,1,   MCP1↓,1,   MDM2↓,1,   MIP2↓,1,   miR-200b↑,1,   MMP↓,3,   MMP1↓,1,   MMP2↓,3,   MMP7↓,1,   MMP9↓,2,   MMPs↓,1,   mTOR↓,1,   Myc↓,1,   NF-kB↓,3,   NHE1↓,1,   NOTCH↓,1,   NOTCH1↓,1,   NOXA↑,1,   OCR↑,1,   other↓,1,   other↝,1,   OXPHOS↑,1,   P-gp↓,1,   P21↑,1,   P450↓,1,   P53↑,2,   cl‑PARP↑,3,   PD-L1↓,1,   PDGF↓,1,   p‑PDGFR-BB↓,1,   PDH↑,1,   PDK1?,2,   PI3K↓,1,   PKCδ↓,1,   PPARα↓,1,   PPP↓,1,   PSA↓,1,   PTEN↑,1,   PUMA↑,2,   RadioS↑,2,   RAGE↓,1,   p‑RB1↓,2,   Risk↓,1,   ROS↓,1,   ROS↑,6,   ROS↝,1,   selectivity↑,4,   SIRT1↓,1,   SIRT6↑,1,   Slug↓,1,   SMAD3↓,1,   Snail↓,2,   Sp1/3/4↓,1,   STAT3↓,3,   p‑STAT3↓,1,   survivin↓,2,   Telomerase↓,1,   Tf↓,1,   TGF-β↓,2,   TNF-α↓,1,   TNFR 1↑,1,   TOP1↓,1,   TOP2↑,1,   toxicity↓,1,   TRAILR↑,1,   TSP-1↑,1,   TumCCA↑,3,   TumCG↓,1,   TumCI↓,1,   TumCMig↓,1,   TumCP↓,2,   tumCV↓,2,   TumVol↓,1,   Twist↓,1,   UPR↑,1,   VEGF↓,4,   Vim↓,1,   Wnt↓,1,   Wnt/(β-catenin)↓,1,   XBP-1↑,1,   XIAP↓,2,   β-catenin/ZEB1↓,2,  
Total Targets: 180

Results for Effect on Normal Cells:
angioG↑,2,   angioG↝,1,   antiOx↑,2,   Apoptosis↓,2,   ATP↝,1,   ATP∅,1,   Aβ↓,1,   BAX↑,1,   BBB↑,1,   Bcl-xL↓,1,   BioAv↓,1,   BioAv↑,1,   BMD↑,1,   BMPs↑,1,   Ca+2↝,7,   cal2↓,2,   Calcium↑,1,   Casp3↓,2,   Catalase↑,1,   chemoP↑,1,   ChemoSideEff↓,1,   cognitive↑,2,   COL2A1↑,1,   Copper↓,1,   Cyt‑c↓,1,   Cyt‑c↑,1,   Diff↑,1,   Dose↑,1,   Dose↝,1,   E-cadherin↑,1,   ECAR∅,1,   eff↑,1,   ER Stress↓,1,   F-actin↓,1,   Fenton↓,1,   GLUT1↑,1,   GLUT3↑,1,   GPx↑,2,   GRP78/BiP↓,1,   GSH↑,1,   GSR↑,1,   hs-CRP↓,1,   IL10↑,1,   IL1β↓,2,   IL6↓,1,   Inflam↓,3,   iNOS↓,1,   Iron↓,1,   LDH↓,1,   lipid-P↓,1,   Mag↑,1,   MAPK↑,1,   memory↑,2,   MMP↓,1,   MMP↑,1,   MSCs↑,1,   mtDam↓,1,   N-cadherin↓,1,   NAD↝,1,   neuroP↑,3,   NF-kB↓,3,   NO↓,2,   NRF2↓,1,   NRF2↑,2,   other?,1,   other↑,1,   other↝,3,   PGE2↓,1,   pH↝,1,   PKCδ?,1,   RenoP↑,1,   Risk↓,1,   ROS↓,3,   ROS∅,1,   SAM-e↑,1,   selectivity↑,1,   serineP↓,1,   Snail↓,1,   SOD↑,1,   SOX9↑,1,   p‑tau↓,1,   testos↑,1,   TGF-β↑,1,   TNF-α↓,3,   toxicity↓,1,   toxicity∅,2,   TumCMig↓,1,   UPR↓,2,   VEGF↓,1,   VEGF↑,1,   Vim↓,1,   VitD↑,1,   ZO-1↑,1,  
Total Targets: 93

Scientific Paper Hit Count for: Ca+2, Calcium Ion Ca+2
2 Magnetic Fields
1 Allicin (mainly Garlic)
1 Baicalin
1 Boron
1 Boswellia (frankincense)
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Melatonin
1 Mushroom Lion’s Mane
1 Phenylbutyrate
1 temozolomide
1 Quercetin
1 Resveratrol
1 Radio Frequency
1 Selenium
1 Silver-NanoParticles
1 Resiquimod
1 Taurine
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:38  State#:0  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

Home Page