Database Query Results : , , GSK‐3β

GSK‐3β, Glycogen synthase kinase (GSK)3β: Click to Expand ⟱
Source:
Type:
GSK3β is a crucial member of the Wnt/β-catenin-, hedgehog (Hh)-, notch- and c-myc-mediated major pro-oncogenic pathways, while also being a negative regulator of epithelial–mesenchymal transition (EMT). Accumulating evidence defines GSK3β as a potential therapeutic target in cancer, thus encouraging the development of GSK3β inhibitors for cancer treatment.
Glycogen synthase kinase 3 beta (GSK-3β) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Its expression and activity have been implicated in several types of cancer, often with varying prognostic implications.

In many cancers, decreased GSK-3β activity is associated with poor prognosis, while in others, increased activity may correlate with aggressive disease.


Scientific Papers found: Click to Expand⟱
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
589- Api,  5-FU,    Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro
- in-vitro, PC, Bxpc-3
GSK‐3β↓, NF-kB↓,
270- Api,    Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK
- in-vivo, AML, U937
Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB↓, cycD1↓, cycA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, Foxm1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, β-catenin/ZEB1↓, p‑Akt↓, GSK‐3β↓, p‑β-catenin/ZEB1↑, cycD1↓, cMyc↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2↓, CRP↓,
3793- CUR,    Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *memory↑,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2922- LT,    Combination of transcriptomic and proteomic approaches helps unravel the mechanisms of luteolin in inducing liver cancer cell death via targeting AKT1 and SRC
- in-vitro, Liver, HUH7
Half-Life↝, TumCCA↑, AKT1↓, ATF2↓, NF-kB↓, GSK‐3β↓, cMyc↓, GSTs↓, TrxR1↓, ROS↑,
4295- LT,    Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
- in-vivo, AD, NA
*Aβ↓, *GSK‐3β↓, *p‑tau↓, *BBB↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1↓, cycE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2↓, lipid-P↓, GSH↑, NRF2↑,
3728- MF,    Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *Apoptosis↓, *ROS↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27↑,
2033- PB,    Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*p‑tau↓, *GSK‐3β↓, *ac‑Histones↑, *neuroP↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1↓, CycB↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2↓, eff↑, Bax:Bcl2↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
62- QC,  GoldNP,    Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231)
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
EGFR↓, PI3k/Akt/mTOR↓, GSK‐3β↓,
82- QC,  AG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, NA
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
4288- RES,    Trans-resveratrol Inhibits Tau Phosphorylation in the Brains of Control and Cadmium Chloride-Treated Rats by Activating PP2A and PI3K/Akt Induced-Inhibition of GSK3β
- in-vivo, AD, NA
*memory↑, *GSH↑, *ROS↓, *MDA↓, *p‑tau↓, *PI3K↑, *Akt↑, *AMPK↑, *PP2A↑, *GSK‐3β↓,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,
3792- RosA,    Molecular docking and dynamics simulations revealed the potential inhibitory activity of honey-iQfood ingredients against GSK-3β and CDK5 protein targets for brain health
- Analysis, AD, NA
*CDK5↓, *GSK‐3β↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 40

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   AIF↑,1,   Akt↓,9,   p‑Akt↓,7,   AKT1↓,1,   ALAT↓,1,   ALP↓,1,   AMPK↓,1,   AMPK↑,1,   AMPKα↓,1,   angioG↓,7,   angioG↑,1,   AntiCan↑,2,   antiOx↑,1,   AP-1↓,2,   Apoptosis↑,6,   AR↓,3,   AST↓,1,   ATF2↓,1,   ATF4↝,1,   ATG7↑,1,   BAD↓,1,   BAX↓,1,   BAX↑,6,   Bax:Bcl2↑,2,   Bcl-2↓,4,   Bcl-2↑,1,   cl‑Bcl-2↓,1,   Bcl-xL↓,2,   Beclin-1↑,1,   BID↓,1,   BioAv↓,2,   BioAv↑,2,   BioEnh↑,1,   Ca+2↝,1,   i-Ca+2↑,1,   cal2↓,1,   Casp↑,1,   Casp10↑,1,   Casp3↑,10,   cl‑Casp3↑,1,   Casp7↑,3,   Casp8↑,3,   cl‑Casp8↑,2,   Casp9↑,6,   CDC2↓,1,   CDC25↓,2,   CDK1↓,2,   p‑CDK1↓,2,   CDK2↓,3,   CDK4↓,5,   CDK6↓,2,   chemoP↑,1,   ChemoSen↑,8,   ChemoSideEff↓,2,   CHOP↑,3,   CK2↓,1,   CLDN2↓,1,   cMET↓,1,   cMyc↓,7,   COL1↓,1,   COL3A1↓,1,   COX2↓,6,   CRP↓,1,   CSCs↓,2,   CXCL1↓,1,   CXCR4↓,2,   cycA1↓,2,   cycA1↑,1,   CycB↓,3,   cycD1↓,9,   cycE↓,1,   CYP1B1↑,1,   Cyt‑c↑,5,   DFF45↑,1,   Diablo↑,1,   DLC1↑,1,   DNAdam↑,3,   DNMT1↓,1,   Dose?,1,   Dose↑,1,   Dose∅,2,   DR5↑,3,   E-cadherin↓,3,   E-cadherin↑,1,   E2Fs↓,1,   eff↓,1,   eff↑,19,   eff↝,1,   eff∅,1,   EGF↓,1,   EGFR↓,3,   eIF2α↓,1,   eIF2α↑,1,   p‑eIF2α↑,1,   EMT↓,5,   ER Stress↑,5,   ER(estro)↓,1,   ERK↓,4,   p‑ERK↓,1,   p‑ERK↑,1,   FAK↓,1,   p‑FAK↑,1,   Fas↑,2,   Foxm1↓,1,   FOXO↑,1,   FOXO3↓,2,   frataxin↑,1,   Glycolysis↓,1,   GRP78/BiP↑,2,   GSH↓,2,   GSH↑,1,   GSK‐3β↓,20,   p‑GSK‐3β↓,1,   GSTs↓,1,   GutMicro↑,1,   H3↓,1,   Half-Life↝,2,   HDAC↓,1,   HDAC1↓,1,   HDAC10↓,1,   Hif1a↓,3,   HK2↓,2,   HO-1↑,2,   HSP27↓,1,   HSP70/HSPA5↓,2,   HSP90↓,1,   ICAD↓,1,   ICAM-1↓,1,   IFN-γ↓,1,   Igs↑,1,   IKKα↓,1,   p‑IKKα↓,1,   IL1↓,1,   IL10↓,1,   IL10↑,1,   IL12↓,1,   IL1β↓,1,   IL1β↑,1,   IL2↓,1,   IL2↑,2,   IL6↓,4,   IL8↓,1,   Inflam↓,4,   iNOS↓,3,   ITGA5↓,1,   ITGB1↓,1,   ITGB3↓,1,   JAK2↓,1,   JNK↑,3,   KRAS↓,1,   LC3II↑,2,   LDHA↓,1,   LEF1↓,1,   lipid-P↓,1,   lipid-P↑,1,   MAPK↑,1,   Mcl-1↓,3,   MDM2↓,1,   MDR1↓,1,   MGMT↓,1,   miR-148a↓,1,   miR-19b↓,1,   miR-21↓,1,   MMP↓,5,   MMP2↓,6,   MMP7↓,2,   MMP9↓,7,   MMPs↓,6,   MRP1↓,1,   mtDam↑,1,   mTOR↓,7,   p‑mTOR↓,1,   Myc↓,1,   N-cadherin↓,1,   NADPH↓,1,   NF-kB↓,13,   NF-kB↑,1,   p‑NF-kB↑,1,   NKX3.1↑,1,   NOTCH↓,1,   NOTCH1↓,1,   NRF2↑,3,   OS↑,1,   other↓,1,   other↑,1,   P-gp↓,4,   p16↑,1,   P21↑,8,   p27↓,1,   p27↑,4,   p38↑,2,   P450↓,1,   P53↑,7,   p62↓,1,   p65↓,1,   P70S6K↓,2,   cl‑PARP↑,7,   PARP1↑,1,   PD-L1↓,1,   PERK↑,1,   PFK↓,1,   PI3K↓,4,   PI3K/Akt↓,1,   PI3k/Akt/mTOR↓,1,   PKCδ↓,1,   PKM2↓,2,   PPARγ↑,1,   PRAS40↓,1,   Prx4↑,1,   PSA↓,1,   PTEN↑,3,   p‑PTEN↓,1,   PUMA↑,1,   RadioS↑,2,   RAGE↓,1,   RAS↓,2,   p‑RB1↓,2,   ROCK1↓,1,   ROS↓,3,   ROS↑,11,   ROS⇅,3,   selectivity↑,6,   Shh↓,1,   Slug↓,2,   Snail↓,4,   SOX4↑,1,   SOX9↓,1,   Sp1/3/4↓,2,   STAT1↓,1,   STAT3↓,7,   STAT6↓,1,   survivin↓,6,   Telomerase↓,1,   TET2↑,1,   TGF-β↓,1,   TLR4↓,2,   TNF-α↓,3,   TNFR 1↑,1,   TOP1↓,1,   TOP2↓,3,   TRAIL↑,2,   TRAILR↑,1,   TrxR↓,1,   TrxR1↓,1,   TSP-1↑,1,   TumAuto↑,2,   TumCCA↑,11,   TumCG↓,1,   TumCI↓,3,   TumCMig↓,2,   TumCP↓,4,   tumCV↓,1,   TumMeta↓,4,   Twist↓,3,   UHRF1↓,1,   UPR↑,1,   VEGF↓,9,   VEGFR2↓,1,   Vim↓,4,   Wnt↓,1,   XBP-1↑,1,   XIAP↓,2,   Zeb1↓,2,   α-tubulin↓,1,   β-catenin/ZEB1↓,6,   p‑β-catenin/ZEB1↓,1,   p‑β-catenin/ZEB1↑,1,  
Total Targets: 268

Results for Effect on Normal Cells:
4-HNE↓,1,   5HT↑,2,   5LO↓,2,   Ach↑,1,   AChE↓,7,   AGEs↓,1,   AIF↓,1,   Akt↑,3,   p‑Akt↑,1,   ALAT↓,1,   ALP↓,1,   AMPK↑,4,   angioG↓,1,   angioG↑,1,   AntiAg↑,1,   AntiAge↑,1,   antiOx↑,9,   Apoptosis↓,3,   AST↓,1,   ATP↑,3,   Aβ↓,8,   BACE↓,2,   Bax:Bcl2↓,1,   BBB↓,1,   BBB↑,3,   BChE↓,1,   BDNF↓,1,   BDNF↑,3,   Beclin-1↑,1,   BioAv↓,6,   BioAv↑,2,   BioAv↝,2,   BloodF↑,1,   BP↓,2,   Ca+2↓,1,   CaMKII ↓,1,   cardioP↑,4,   Casp3↓,4,   Casp9↓,2,   Casp9↑,1,   Catalase↑,8,   CDK5↓,5,   CHOP↓,1,   cognitive↑,9,   COX1↓,1,   COX2↓,9,   CREB↑,1,   Cyt‑c↓,1,   Cyt‑c∅,1,   Dose↝,1,   eff↑,6,   ERK↑,1,   FOXO↑,1,   GABA↑,1,   GPx↑,5,   GR↑,1,   GRP78/BiP↓,1,   GRP78/BiP↑,1,   GSH↑,6,   GSK‐3β↓,20,   GSR↓,1,   GSTA1↑,1,   GutMicro↑,1,   H2O2↓,2,   Half-Life↑,1,   Half-Life↝,2,   HDAC↓,1,   hepatoP↑,2,   ac‑Histones↑,1,   HO-1↑,7,   HSP70/HSPA5↝,1,   IFN-γ↓,1,   IL10↓,1,   IL10↑,1,   IL12↓,1,   IL17↓,3,   IL1β↓,11,   IL2↓,1,   IL23↓,1,   IL33↓,1,   IL4↓,1,   IL4↑,1,   IL6↓,4,   IL8↓,1,   INF-γ↓,1,   Inflam↓,13,   iNOS↓,4,   IronCh↑,1,   JNK↓,1,   p‑JNK↓,1,   LC3II↑,1,   LDH↓,1,   LDL↓,1,   lipid-P↓,5,   mt-lipid-P↓,1,   MAOA↓,1,   MAPK↓,1,   MCP1↓,2,   MDA↓,4,   memory↑,9,   Mets↝,1,   MMP↑,2,   MMP13↓,1,   MMP3↓,1,   MMP9↓,1,   Mood↑,1,   motorD↑,3,   MPO↓,2,   mTOR↓,1,   NADH:NAD↑,1,   NADPH↓,1,   neuroP↑,13,   NF-kB↓,7,   NLRP3↓,2,   NO↓,3,   NO↑,1,   NQO1↑,3,   Nrf1↑,1,   NRF2↑,10,   OS↑,2,   p38↓,1,   P450↓,1,   p65↓,1,   Pain↓,1,   PGC-1α↑,3,   PGE2↓,4,   PGE2↑,1,   PI3K↑,2,   PP2A↑,3,   PPARγ↑,6,   ROS↓,16,   mt-ROS↓,1,   SIRT1↑,3,   SIRT3↑,1,   SOD↑,10,   STAT↓,1,   tau↓,2,   p‑tau↓,12,   TBARS↓,1,   Th1 response↓,1,   Th2↑,2,   TLR4↓,2,   TNF-α↓,11,   toxicity↓,1,   TrkB↑,2,   TXNIP↓,1,   UPR↑,1,   VitC↑,1,   β-catenin/ZEB1↑,1,  
Total Targets: 149

Scientific Paper Hit Count for: GSK‐3β, Glycogen synthase kinase (GSK)3β
6 Curcumin
4 Quercetin
3 Apigenin (mainly Parsley)
3 Luteolin
3 Propolis -bee glue
3 Resveratrol
2 Thymoquinone
1 Alpha-Lipoic-Acid
1 5-fluorouracil
1 Baicalein
1 Berberine
1 Boswellia (frankincense)
1 Caffeic acid
1 Chrysin
1 Hydroxycinnamic-acid
1 Honokiol
1 Lycopene
1 Magnetic Fields
1 Naringin
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Gold NanoParticles
1 Arctigenin
1 Rosmarinic acid
1 Vitamin B1/Thiamine
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:385  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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