Database Query Results : , , PARP1

PARP1, Poly [ADP-ribose] polymerase 1: Click to Expand ⟱
Source:
Type:
PARP1 accounts for 90% of the PARP family of enzymes. PARP-1 (poly(ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes.
The close connection between PARP1 and the tumor suppressor protein p53 is also of great interest to those who study the complex role of PARP1 in cancer promotion or suppression.
PARP1 inhibition, which blocks the JNK-PARP1-JNK loop and ERK-mediated anti-apoptotic protein expression, will result in cancer apoptosis.

PARP1 Overexpression:
In several cancer types—including breast, ovarian, prostate, and lung cancers—elevated PARP1 expression and/or activity has been reported.
High PARP1 expression in certain cancers has been associated with aggressive tumor behavior and resistance to therapies (especially those that induce DNA damage).
Increased PARP1 activity may correlate with poorer overall survival in tumors that rely on DNA repair for survival.
Scientific Papers found: Click to Expand⟱
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   p‑Akt↓,1,   AntiAg↓,1,   Apoptosis↑,1,   BAX↑,1,   Casp3↓,1,   Casp3↑,3,   Casp9↑,2,   CDK6↓,1,   cFLIP↓,1,   ChemoSen↑,2,   CHOP↑,1,   CLDN2↓,1,   cMyc↓,1,   COX2↓,1,   CXCL12↓,1,   CXCR4↓,1,   cycD1↓,1,   Cyt‑c↑,1,   Diablo↑,1,   DNMTs↓,1,   E-cadherin↑,1,   eff↑,4,   EGFR↓,1,   p‑eIF2α↑,1,   EMT↓,1,   ER Stress↑,2,   p‑ERK↓,1,   GSK‐3β↓,1,   p‑GSK‐3β↓,1,   ac‑H3↑,1,   ac‑H4↑,1,   HDAC↓,1,   Hif1a↓,1,   IL10↓,1,   IL6↓,1,   iNOS↓,1,   Ki-67↓,1,   lipid-P↑,1,   MMP↓,2,   MMP2↓,1,   MMP9↓,1,   MMPs↓,1,   p‑mTOR↓,1,   N-cadherin↓,1,   NO↓,1,   P21↑,1,   p27↑,1,   P53↑,1,   PARP1↑,3,   PCNA↓,1,   PI3K↓,1,   PKCδ↓,1,   PTEN↑,1,   RenoP↑,1,   ROS↓,1,   ROS↑,2,   Snail↓,1,   STAT3↓,1,   TGF-β↓,1,   TSP-1↑,1,   TumCCA↑,2,   TumMeta↓,1,   uPA↓,1,   VEGF↓,1,   VEGFR2↓,1,   Vim↓,1,   β-catenin/ZEB1↓,2,   p‑β-catenin/ZEB1↓,1,  
Total Targets: 69

Results for Effect on Normal Cells:
AntiCan↑,1,   antiOx↑,2,   BBB↑,1,   BG↓,1,   GSH↑,2,   Inflam↓,1,   IronCh↑,1,   NRF2↑,1,   ROS↓,1,  
Total Targets: 9

Scientific Paper Hit Count for: PARP1, Poly [ADP-ribose] polymerase 1
1 Alpha-Lipoic-Acid
1 Naringin
1 Quercetin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:400  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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