Database Query Results : , , IGF-1

IGF-1, insulin-like growth factor-1: Click to Expand ⟱
Source:
Type:
Higher blood levels of IGF-1, a growth factor, are linked to increased risk of several types of cancer, including thyroid, melanoma and myeloma. IGF-1 is what some call "a growth-promoter" because it has been shown to promote the growth of cancer cells.
The IGF-1 signaling pathway promotes cancer progression; its downregulation is associated with lowered risk.
Scientific Papers found: Click to Expand⟱
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoP↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoP↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2695- BBR,    The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
- Trial, BC, NA
IGF-1↓, PPARγ↓, VEGF↓, Hif1a↓, angioG↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
3518- Bor,    Boron Report
- Review, Var, NA - Review, AD, NA
Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
706- Bor,    Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice
- in-vivo, Pca, LNCaP
TumVol↓, IGF-1↓, PSA↓,
746- Bor,    Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
- Review, NA, NA
eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑,
446- CUR,    The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
- in-vitro, CRC, SW480
IR↓, IGF-1↓, Myc↓, TumCMig↓, TumCP↓,
1855- dietFMD,    Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study
- Trial, NA, NA
ChemoSideEff↓, QoL↑, IGF-1↓, Insulin↓,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
ChemoSideEff↓, *toxicity↓, mTOR↓, IGF-1↓, IGFBP1↑, BG↓, ROS↑,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,
1842- dietFMD,    Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment
- Trial, Var, NA
Strength∅, Weight∅, IGF-1↓, IGFBP3↑, IGFBP1↑, eff↑,
1843- dietFMD,  BTZ,    Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
- in-vivo, CLL, NA
AntiTum↓, Apoptosis↑, IGF-1↓, eff↑, OS↑, eff↑,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
2265- dietMet,    Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
- in-vivo, Nor, NA
*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1↓,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
649- EGCG,  CUR,  PI,    Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
*BioEnh↑, EGFR↓, HER2/EBBR2↓, IGF-1↓, MAPK↓, ERK↓, RAS↓, Raf↓, NF-kB↓, p‑pRB↓, TumCCA↑, Glycolysis↓, Warburg↓, HK2↓, Pyruv↓,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, NA, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1↓, cycE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
3255- PBG,    Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
- in-vivo, Nor, NA
*IGF-1↓, *MMP2↑, *ROS↓, *Inflam↓, *IL10↓, *NRF2∅,
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
IGF-1↓, IGF-2↓, IGFBP3↑, Bcl-2↓, Bcl-xL↓, Casp3↑,
86- QC,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- in-vitro, Pca, PC3
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1↓, IGF-1↓, IGF-2↓, IGF-1R↓,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27↑, TumCCA↑, ChemoSen↑, COX2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3094- RES,    Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
CSCs↓, tumCV↓, FASN↑, BNIP3↑, *cardioP↑, *antiOx↑, NF-kB↓, COX2↓, MMP9↓, IGF-1↓, ERK↓, lipid-P↓, CD24↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,
3043- SK,    Shikonin Induces Apoptosis by Inhibiting Phosphorylation of IGF-1 Receptor in Myeloma Cells.
- in-vitro, Melanoma, RPMI-8226
IGF-1↓, Apoptosis↑, TumCCA↑, MMP↓, Casp3↑, P53↑, BAX↑, Mcl-1↓, EGFR↓, Src↑, KDR/FLK-1↓, p‑IGF-1↓, PI3K↓, Akt↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 41

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   adiP↑,1,   Akt↓,9,   Akt↑,1,   p‑Akt↓,2,   AMPK↑,3,   angioG↓,7,   AntiAg↑,1,   AntiCan↑,8,   antiOx⇅,1,   AntiTum↓,1,   APAF1↑,1,   Apoptosis↑,6,   AR↓,3,   ATF4↑,1,   ATF6↑,1,   ATG3↑,1,   ATP↓,2,   ATP↑,1,   BAD↑,1,   Bak↑,2,   BAX↑,5,   Bax:Bcl2↑,2,   BBB↑,1,   Bcl-2↓,5,   Bcl-xL↓,4,   Beclin-1↓,1,   Beclin-1↑,1,   BG↓,4,   BID↑,1,   BioAv↓,3,   BioAv↑,1,   BioAv∅,1,   BioEnh↑,1,   BNIP3↑,1,   BRAF↝,1,   Brk/PTK6↓,1,   Ca+2↓,1,   Ca+2↑,2,   cal2↑,1,   Casp↑,2,   Casp10↑,1,   Casp12↑,1,   Casp3↑,12,   cl‑Casp3↑,1,   Casp7↑,1,   cl‑Casp7↑,1,   Casp8↑,1,   cl‑Casp8↑,1,   Casp9↑,5,   cl‑Casp9↑,2,   Catalase↓,1,   Catalase↑,1,   CD14↓,1,   CD24↓,1,   CD44↓,1,   CD8+↑,3,   Cdc42↓,1,   CDK1↓,1,   CDK2↓,5,   CDK4↓,5,   CDK6↓,4,   chemoP↑,3,   ChemoSen↓,1,   ChemoSen↑,11,   ChemoSideEff↓,4,   CHOP↑,1,   CK2↓,4,   cMyc↓,2,   COX2↓,6,   CRM↑,1,   CRP↓,1,   CSCs↓,3,   CXCR4↓,1,   Cyc↓,2,   cycA1↓,1,   CycB↓,1,   cycD1↓,5,   CycD3↓,1,   cycE↓,2,   CYP1A1↓,1,   CYP1A2↓,1,   Cyt‑c↑,7,   Diablo↑,1,   DNAdam↑,3,   DNMTs↓,1,   Dose↑,2,   Dose↝,4,   DR5↑,1,   E-cadherin↑,5,   E6↓,1,   E7↓,1,   eff↓,3,   eff↑,24,   eff↝,3,   EGFR↓,6,   eIF2α↑,1,   EMT↓,1,   ERK↓,6,   p‑ERK↓,1,   FAK↓,3,   Fas↑,2,   FASN↓,2,   FASN↑,1,   Ferritin↓,1,   Fibronectin↓,1,   FOXO3↓,1,   FOXO3↑,1,   FOXO4↓,1,   Gli↓,1,   GLUT1↓,1,   GlutMet↓,1,   glyC↓,1,   Glycolysis↓,4,   GPx↑,2,   GR↑,1,   GSH↓,2,   GSH↑,3,   p‑GSK‐3β↓,1,   GSTs↑,2,   GutMicro↑,3,   H3↓,1,   Half-Life↓,1,   Half-Life↝,1,   Half-Life∅,1,   HDAC↓,3,   HDAC1↓,2,   HDAC3↓,1,   HER2/EBBR2↓,3,   HIF-1↓,2,   Hif1a↓,11,   HK2↓,1,   HO-1↓,3,   HO-1↑,3,   HSP27↝,1,   HSP70/HSPA5↓,1,   HSP70/HSPA5↝,1,   HSP90↓,1,   HSPs↓,1,   cl‑IAP2↑,1,   IFN-γ↑,1,   IGF-1↓,35,   p‑IGF-1↓,1,   IGF-1R↓,3,   IGF-2↓,2,   IGFBP1↑,3,   IGFBP3↑,4,   IGFR↓,1,   IKKα↓,1,   IL1↓,2,   IL10↑,1,   IL12↓,1,   IL1β↓,2,   IL4↑,1,   IL6↓,6,   IL8↓,2,   iNOS↓,1,   Insulin↓,5,   IR↓,1,   Iron↑,1,   ITGB4↓,1,   JNK↑,1,   p‑JNK↓,1,   KDR/FLK-1↓,1,   Keap1↓,1,   Ki-67↓,2,   LAMP2↑,1,   LAT↓,1,   lipid-P↓,1,   M2 MC↓,2,   MAPK↓,4,   MAPK↝,1,   Mcl-1↓,2,   MDA↓,1,   MDA↑,1,   p‑MEK↓,1,   miR-21↓,1,   MMP↓,4,   MMP1↓,2,   MMP2↓,4,   MMP3↓,1,   MMP7↓,2,   MMP9↓,7,   MMPs↓,3,   MPO↓,1,   mTOR↓,8,   Myc↓,1,   N-cadherin↓,1,   NAD↝,1,   NADPH↓,1,   NADPH↑,1,   NF-kB↓,9,   NK cell↑,1,   NO↓,1,   NRF2↓,2,   NRF2↑,3,   OS↑,3,   OXPHOS↑,1,   OXPHOS↝,1,   P21↓,1,   P21↑,8,   p27↑,7,   p38↑,2,   P450↓,1,   p50↓,1,   P53?,1,   P53↓,1,   P53↑,6,   p62↓,1,   p62↑,1,   cl‑PARP↑,6,   PCNA↓,1,   PD-1↓,1,   PDGF↓,1,   PFK↓,1,   PGE2↓,2,   PI3K↓,7,   PI3K↑,1,   PI3K/Akt↓,1,   PI3K/Akt↝,1,   PKCδ↓,1,   POLD1↓,1,   polyA↓,1,   PPARγ↓,1,   PPARγ↑,1,   p‑pRB↓,2,   PSA↓,7,   PSA∅,1,   PSMB5↓,1,   PTEN↑,2,   PTEN↝,1,   PUMA↑,1,   Pyruv↓,1,   QoL↑,3,   RadioS↑,5,   Raf↓,2,   RAS↓,1,   Rho↓,1,   Risk↓,3,   ROS↑,18,   SAM-e↝,1,   selectivity↑,2,   serineP↓,1,   SIRT1↑,3,   Slug↓,1,   SMAD2↓,1,   SMAD3↓,1,   Snail↓,2,   SOD↓,2,   SOD↑,3,   Src↑,1,   STAT3↓,4,   STAT5↓,2,   Strength∅,1,   survivin↓,1,   Telomerase↓,3,   TGF-β↓,1,   Th1 response↑,1,   TNF-α↓,4,   TOP1↓,1,   TOP2↓,1,   toxicity∅,2,   Treg lymp↓,1,   TS↓,1,   TumCCA↑,9,   TumCD↑,2,   TumCG↓,4,   TumCI↓,2,   TumCMig↓,2,   TumCP↓,4,   tumCV↓,4,   TumMeta↓,3,   TumVol↓,5,   Twist↓,3,   uPA↓,1,   VCAM-1↓,1,   VEGF↓,11,   VEGFR2↓,1,   Vim?,1,   Vim↓,1,   Warburg↓,2,   Weight↓,1,   Weight∅,1,   Wnt↓,1,   XIAP↓,2,   Zeb1↓,2,   β-catenin/ZEB1↓,3,  
Total Targets: 287

Results for Effect on Normal Cells:
5LO↓,1,   adiP↑,2,   Akt↓,1,   antiOx?,1,   antiOx↑,4,   ATF4↑,1,   ATP↝,1,   BioEnh↑,1,   BMD↑,1,   BMPs↑,1,   Ca+2↝,1,   Calcium↑,2,   cardioP↑,2,   Catalase↑,3,   chemoP↑,1,   ChemoSideEff↓,1,   cognitive↑,3,   COX2↓,1,   DNArepair↑,1,   Dose↑,1,   Dose↝,1,   Dose∅,1,   eff↓,1,   eff↑,1,   FGF21↑,2,   glucose↓,2,   GlucoseCon↑,2,   GLUT4↑,1,   Glycolysis↑,1,   Glycolysis↝,1,   GPx↑,1,   GSH↑,3,   GSR↑,1,   GSTA1↑,1,   GutMicro↑,1,   H2S↑,1,   HK2↑,2,   HO-1↑,1,   hs-CRP↓,1,   IGF-1↓,6,   IGFBP3↑,1,   IGFR↓,1,   IL10↓,1,   Inflam↓,6,   Insulin↓,2,   Keap1↓,1,   LDH↓,1,   LDHA↑,1,   Mag↑,2,   MAPK↓,2,   MDA↓,2,   memory↑,1,   MMP2↑,1,   mTOR↓,1,   NAD↝,1,   neuroP↑,3,   NF-kB↓,1,   NQO1↑,1,   NRF2↑,2,   NRF2∅,1,   OS↑,2,   other↓,1,   PFK↑,1,   PGE2↓,1,   PI3K↓,1,   PKCδ↓,1,   PKM2↑,2,   PPARα↑,1,   RAS↓,1,   Risk↓,1,   ROS↓,5,   mt-ROS↓,1,   SAM-e↑,1,   SCD1↓,1,   selectivity↑,1,   serineP↓,1,   SIRT2↑,1,   SOD↑,4,   testos↑,1,   TNF-α↓,1,   toxicity↓,2,   VitD↑,2,   Weight↓,1,  
Total Targets: 83

Scientific Paper Hit Count for: IGF-1, insulin-like growth factor-1
11 diet FMD Fasting Mimicking Diet
5 Boron
4 diet Methionine-Restricted Diet
4 Resveratrol
3 EGCG (Epigallocatechin Gallate)
2 Apigenin (mainly Parsley)
2 Curcumin
2 Chemotherapy
2 Quercetin
1 Berberine
1 Betulinic acid
1 Vitamin C (Ascorbic Acid)
1 Bortezomib
1 diet Short Term Fasting
1 Piperine
1 Fisetin
1 Luteolin
1 Lycopene
1 Methylsulfonylmethane
1 Propolis -bee glue
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:415  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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