Database Query Results : , , AMPKα

AMPKα, AMP-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK is a heterotrimeric protein complex consisting of three subunits: AMPKα, AMPKβ, and AMPKγ. AMPKα is expressed in two isoforms, AMPKα1 and AMPKα2, and these isoforms are encoded by the genes PRKAA1 and PRKAA2, respectively.
In many cancers, AMPKα acts as a tumor suppressor, and its downregulation is often associated with worse clinical outcomes.
Scientific Papers found: Click to Expand⟱
2631- Api,    Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
- in-vivo, GC, NA - in-vitro, GC, AGS
ER Stress↑, Hif1a↓, EZH2↓, HDAC↓, TumAuto↑, p‑mTOR↓, AMPKα↑, GRP78/BiP↑, ROS↑, MMP↓, Ca+2↑, ATF4↑, CHOP↑,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, NA, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,
919- QC,    Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells
- in-vitro, CRC, HCT116
Apoptosis↑, ROS↑, SESN2↑, P53↑, AMPKα↑, mTOR↓,
318- SNP,    Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
- in-vitro, Pca, PC3
lysoM↓, lysosome↓, AMPKα↑, TumAuto↑, mTOR↑,
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   p‑Akt↓,1,   AMPKα↑,6,   Apoptosis↑,4,   ASK1↑,1,   ATF4↑,1,   BioAv↓,1,   Ca+2↑,2,   Casp3↑,1,   Casp8↑,1,   Casp9↑,1,   cFLIP↓,1,   ChemoSen↑,1,   CHOP↑,1,   Dose↝,1,   DR5↑,1,   eff↓,2,   eff↑,1,   ER Stress↑,1,   EZH2↓,1,   GRP78/BiP↑,1,   GSH↓,2,   GSK‐3β↑,1,   HDAC↓,1,   Hif1a↓,1,   HO-1↑,1,   HSF1↓,1,   HSP70/HSPA5↑,1,   lysoM↓,1,   lysosome↓,1,   MAPK↑,1,   MMP↓,2,   mTOR↓,2,   mTOR↑,1,   p‑mTOR↓,1,   NK cell↑,1,   NRF2↑,1,   p38↑,1,   P53↑,2,   p70S6↓,1,   p85S6K↓,1,   PI3K↑,1,   RadioS↑,1,   ROS↑,5,   selectivity↑,1,   SESN2↑,1,   p‑STAT3↓,1,   TRAIL↑,1,   TSC2↑,1,   TumAuto↑,2,   TumCCA↑,3,   TumCP↓,1,   β-catenin/ZEB1↓,1,  
Total Targets: 53

Results for Effect on Normal Cells:
e-Akt↑,1,   AMPKα↑,1,   Catalase↑,1,   eff↓,1,   e-ERK↑,1,   GPx↑,1,   GR↑,1,   GSTA1↓,1,   H2O2↓,1,   HO-1↑,2,   lipid-P↓,1,   NRF2↑,1,   ROS↓,1,   ROS⇅,1,   SOD↑,1,   tumCV∅,1,  
Total Targets: 16

Scientific Paper Hit Count for: AMPKα, AMP-activated protein kinase
2 Quercetin
2 Thymoquinone
1 Apigenin (mainly Parsley)
1 Ashwagandha
1 Silver-NanoParticles
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:475  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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