Database Query Results : , , p62

p62, p62/sequestosome 1 (SQSTM1): Click to Expand ⟱

Source:

Type:

A protein that plays a crucial role in various cellular processes, including autophagy, cell signaling, and protein degradation.
p62 is a scaffold protein that interacts with various signaling molecules, including kinases, phosphatases, and ubiquitin ligases. It is also a substrate of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins.
p62 is overexpressed in various types of cancer, including breast, lung, colon, and liver cancer.
Its overexpression has been associated with poor prognosis and reduced survival in some cancers.

Scientific Papers found: Click to Expand⟱

265-

ALA,

Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies

in-vitro,

Pca,

LNCaP

 ALA (25–1000 μM) for 48 h

in-vitro,

Pca,

DU145

ROS↓, SOD↓, GSTP1/GSTπ↓, NRF2↓, p62↓, p62↑, SOD↑, p‑mTOR↑, Beclin-1↓, ROS↑, SOD1↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

1377-

BBR,

Berberine inhibits autophagy and promotes apoptosis of fibroblast-like synovial cells from rheumatoid arthritis patients through the ROS/mTOR signaling pathway

in-vitro,

Arthritis,

10, 20, 30, 40, 50, 60, 70, and 80 μmol/L berberine

Apoptosis↑, MMP↓, Bax:Bcl2↑, LC3‑Ⅱ/LC3‑Ⅰ↓, p62↑, *ROS↓,

2720-

BetA,

Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo

in-vitro,

Cerv,

HeLa

Keap1↝, ROS↑, Ca+2↑, Beclin-1↓, GRP78/BiP↑, LC3II↑, p62↑, ERS↑, TumAuto↑,

1101-

CA,

Tras,

Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells

in-vitro,

BC,

 in ERBB2+ BC cells

ChemoSen↑, HER2/EBBR2↓, PI3K↓, Akt↓, mTOR↓, p62↑,

2019-

CAP,

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

Review,

Var,

chemoP↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,

872-

CUR,

RES,

New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects

in-vitro,

BC,

TUBO

15uM, 15uM

in-vitro,

BC,

SALTO

TumCP↓, tumCV↓, p62↓, p62↑, TumAuto↑, TumAuto↓, ROS↑, ROS↓, CHOP↑,

477-

CUR,

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

in-vitro,

Cerv,

SiHa

5, 15, 30 and 50 µM, 6, 12, 24 and 48 h

TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,

448-

CUR,

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

in-vitro,

CRC,

HT-29

15, 20 and 25 μM, 48 h

Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,

1863-

dietFMD,

Chemo,

Effect of fasting on cancer: A narrative review of scientific evidence

Review,

Var,

eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,

1654-

FA,

Molecular mechanism of ferulic acid and its derivatives in tumor progression

Review,

Var,

AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,

2865-

HNK,

Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma

in-vitro,

MB,

DAOY

vitro+vivo,

NA,

BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,

2177-

itraC,

Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression

Study,

Colon,

present study analyzed extensive data from patients diagnosed with colon cancer using itraconazole between January 2011 and December 2015

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HCT116

OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,

1709-

Lyco,

Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation

in-vitro,

Nor,

JB6

mouse cell line

*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,

227-

MFrot,

MF,

Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway

in-vivo,

Lung,

A549

 0.4T, 7.5 Hz, 4 h/day

 mouse

in-vitro,

Lung,

A549

TumCG↓, miR-486↑, BCAP↓, Apoptosis↑, ROS↑, TumAuto↑, LC3II↑, ATG5↑, Beclin-1↑, p62↑, TumCP↓,

1483-

SFN,

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

in-vitro,

OS,

143B

0-10uM

in-vitro,

Nor,

HEK293

in-vivo,

OS,

25-50mg/kg

subcutaneous tumor-bearing nude mouse model

AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

2009-

SK,

Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer

in-vitro,

Bladder,

TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,

317-

SNP,

Autophagic effects and mechanisms of silver nanoparticles in renal cells under low dose exposure

in-vitro,

Kidney,

HEK293

TumAuto↑, p62↑,

357-

SNP,

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

L132

mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,

2287-

SNP,

Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine

in-vitro,

Nor,

HUVECs

*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 20

Results for Effect on Cancer/Diseased Cells:
AIF↑,1, Akt↓,4, p‑Akt↓,1, angioG↓,1, AntiCan↑,2, antiOx↑,1, Apoptosis↑,7, ATG3↑,1, ATG5↑,2, ATG7↑,1, ATP↑,1, BAD↑,1, p‑BAD↓,1, BAX↑,3, Bax:Bcl2↑,3, BCAP↓,1, Bcl-2↓,3, Beclin-1↓,2, Beclin-1↑,4, BG↓,1, BIM↑,1, BioAv↓,2, Ca+2↑,2, i-Ca+2?,1, CAIX↓,1, Casp3↑,5, cl‑Casp3↑,1, Casp8↑,1, Casp9↑,1, CD8+↑,1, CDC25↓,1, CDK4↓,2, CDK6↓,1, chemoP↑,1, ChemoSen↑,5, ChemoSideEff↓,2, CHOP↑,1, cMyc↓,1, CycB↓,1, cycD1↓,2, Cyt‑c↑,2, DNAdam↑,2, Dose↝,1, Dose∅,1, eff↓,6, eff↑,8, EMT↓,1, ERK↑,1, ERS↑,1, Fap1↓,1, Ferroptosis↑,1, FGFR1↓,1, Glycolysis↓,2, GPx1↓,1, GPx4↓,2, GRP78/BiP↑,1, GSH↓,2, GSTP1/GSTπ↓,1, GutMicro↑,2, HDAC↓,1, HER2/EBBR2↓,1, HH↓,1, Hif1a↑,1, HO-1↓,1, HSP27↑,1, IGF-1↓,1, Inflam↓,1, iNOS↓,1, Insulin↓,1, i-Iron↑,1, JAK2↓,1, JNK↑,1, Keap1↑,1, Keap1↝,1, Ki-67↓,2, LAMP2↑,1, LC3‑Ⅱ/LC3‑Ⅰ↓,1, LC3‑Ⅱ/LC3‑Ⅰ↑,1, LC3B↑,3, LC3II↑,5, LC3s↑,1, LDH↓,1, lipid-P↑,1, M2 MC↓,1, MAPK↓,1, MDA↑,1, miR-34a↑,1, miR-486↑,1, MLKL↑,1, p‑MLKL↓,1, MMP↓,3, MMP9↓,1, mtDam↑,2, mTOR↓,3, p‑mTOR↑,1, Necroptosis↑,2, NF-kB↓,1, NRF2↓,1, OS↑,1, OXPHOS↑,1, P21↑,2, P53↑,5, p‑P53↑,1, p62↓,2, p62↑,18, p‑PARP↑,1, cl‑PARP↑,2, PI3K↓,3, PKM2↓,1, PYCR1↓,1, RadioS↑,1, RIP3↑,1, p‑RIP3↑,1, ROS↓,2, ROS↑,14, selectivity↓,1, selectivity↑,5, SIRT1↑,1, SLC12A5↓,1, SOD↓,2, SOD↑,1, SOD1↑,1, STAT5↓,1, STAT6↓,1, TKT↓,1, Treg lymp↓,1, TRPV1↑,1, TumAuto↓,1, TumAuto↑,7, TumCCA↑,4, TumCD↑,1, TumCG↓,2, TumCG↑,1, TumCI↓,1, TumCMig↑,1, TumCP↓,4, tumCV↓,3, TumVol↓,1, TumW↓,3, VEGF↓,1, Warburg↓,1, β-catenin/ZEB1↓,1,
Total Targets: 142

Results for Effect on Normal Cells:
antiOx↑,1, ATP↓,1, BAX↑,1, Bcl-2↓,1, BioAv↓,1, Casp3↑,1, Casp3∅,1, Catalase↝,1, COX2↓,1, Cyt‑c∅,1, eff↓,1, eff↑,1, GPx↝,1, GR↝,1, GSH↓,1, GSH↑,1, GSH/GSSG↓,1, Inflam↓,1, Keap1↓,1, LC3II↑,1, MDA↑,1, MMP↓,1, MMP∅,1, NF-kB↓,1, NRF2↑,2, p62↑,2, ROS↓,2, ROS↑,1, SOD↝,1, toxicity↓,1, toxicity∅,2, TumCP↓,1, Weight∅,1,
Total Targets: 33

Scientific Paper Hit Count for: p62, p62/sequestosome 1 (SQSTM1)

3 Curcumin
3 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Metformin
1 Berberine
1 Betulinic acid
1 Carnosic acid
1 Trastuzumab
1 Capsaicin
1 Resveratrol
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Ferulic acid
1 Honokiol
1 itraconazole
1 Lycopene
1 Magnetic Field Rotating
1 Magnetic Fields
1 Sulforaphane (mainly Broccoli)
1 Shikonin

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:602  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , p62

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