Database Query Results : , , NADPH

NADPH, Nicotinamide adenine dinucleotide phosphate: Click to Expand ⟱
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Type:
NADPH (Nicotinamide adenine dinucleotide phosphate) is a crucial molecule in cellular metabolism, playing a key role in various biological processes, including energy production, antioxidant defenses, and biosynthesis.
NADPH is essential for the proper functioning of the pentose phosphate pathway, which generates NADPH and ribose-5-phosphate. Cancer cells may exploit this pathway to support their high energy demands.
Many types of cancer, including breast, lung, and colon cancer, exhibit increased NADPH levels compared to normal tissues. This increase is often associated with enhanced glucose-6-phosphate dehydrogenase (G6PD) activity, a key enzyme in the pentose phosphate pathway that generates NADPH.
Scientific Papers found: Click to Expand⟱
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2654- CUR,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, Catalase↓, SOD1↓, GLO-I↓, NADPH↓, TumCCA↑, Apoptosis↑, Akt↓, ER Stress↑, JNK↑, STAT3↓, BioAv↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
2515- H2,    Recent Advances in Studies of Molecular Hydrogen against Sepsis
- Review, Sepsis, NA
*Sepsis↓, *Inflam↓, *antiOx↑, *ROS↓, *NADPH↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1↓, cycE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
964- SIL,    Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCP↓, Hif1a↓, NADPH↓, angioG↓, FASN↓, ACC↓,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Results for Effect on Cancer/Diseased Cells:
ACC↓,1,   ACLY↓,1,   adiP↑,1,   Akt↓,3,   Akt↑,1,   p‑Akt↓,1,   AMPK↑,4,   angioG↓,3,   AntiCan↑,2,   antiOx↑,1,   Apoptosis↑,5,   ATP↓,2,   BAX↓,1,   BAX↑,3,   Bax:Bcl2↑,1,   Bcl-2↓,3,   Bcl-xL↓,1,   BioAv↑,1,   BioAv↝,1,   BMPs↑,1,   Ca+2↑,1,   Casp3↑,3,   cl‑Casp3↑,1,   Casp9↑,1,   cl‑Casp9↑,1,   Catalase↓,1,   CD133↓,1,   CDK2↓,1,   CDK4↓,2,   cFLIP↓,1,   chemoP↑,2,   ChemoSen↑,4,   ChemoSideEff↓,1,   CHOP↑,1,   p‑cMET↑,1,   cMyc↓,1,   COX2↓,2,   CSCs↓,1,   CXCR4↓,1,   cycD1↓,3,   cycE↓,1,   Cyt‑c↑,1,   E-cadherin↑,4,   eff↓,2,   eff↑,7,   eff↝,2,   EGFR↓,2,   eIF2α↑,1,   EMT↓,4,   ER Stress↑,2,   ERK↓,2,   EZH2↓,1,   FAK↓,1,   FASN↓,2,   Ferritin↓,1,   Ferroptosis↑,1,   frataxin↑,1,   GLO-I↓,1,   GLS↓,1,   GlucoseCon↓,1,   GLUT1↓,1,   GLUT3↓,1,   glyC↓,1,   Glycolysis↓,4,   GPx4↓,1,   GRP78/BiP↑,1,   GSDMD↑,1,   GSH↓,2,   GSK‐3β↓,1,   Half-Life↓,2,   HDAC↓,1,   Hif1a↓,4,   HK2↓,3,   HO-1↓,1,   IGF-1↓,1,   IGFBP1↑,1,   IL8↓,1,   Inflam↓,2,   ITGB1↓,1,   ITGB3↓,1,   JNK↑,1,   lactateProd↓,2,   LC3II↑,1,   LDH↓,1,   Mcl-1↓,1,   MDR1↓,1,   MGMT↓,1,   MMP2↓,3,   MMP9↓,3,   MMPs↓,4,   mTOR↓,2,   p‑mTOR↓,1,   N-cadherin↓,2,   NADPH↓,12,   Nestin↓,1,   neuroP↑,1,   NF-kB↓,4,   NLRP3↑,1,   NRF2↓,1,   NRF2↑,1,   other↓,1,   other↝,1,   OXPHOS↑,1,   OXPHOS↝,1,   mt-OXPHOS↑,1,   p16↑,1,   P53↑,1,   p62↓,1,   PDH↓,1,   p‑PERK↑,1,   PFK↓,1,   PI3K↓,1,   PKM2↓,2,   PPP↓,1,   RadioS↑,1,   RAS↑,1,   ROS↑,10,   ROS⇅,1,   mt-ROS↑,1,   selectivity↑,3,   Shh↓,1,   SIRT1↑,1,   SIRT3↑,1,   Snail↓,2,   SOD1↓,1,   STAT3↓,1,   p‑STAT3↓,1,   survivin↓,1,   TIMP2↑,1,   toxicity↑,1,   TumAuto↑,1,   TumCCA↑,3,   TumCD↑,1,   TumCG↓,1,   TumCI↓,2,   TumCMig↓,2,   TumCP↓,5,   tumCV↓,1,   TumMeta↓,2,   Twist↓,1,   uPA↓,1,   VEGF↓,2,   Vim↓,2,   Warburg↓,2,   Wnt↓,1,   Zeb1↓,1,   β-catenin/ZEB1↓,1,  
Total Targets: 147

Results for Effect on Normal Cells:
AChE↓,3,   Akt↓,2,   Akt↑,1,   ALAT↓,1,   ALP↓,1,   AMP↓,1,   AMPK↑,3,   AntiAg↑,1,   AntiAge↑,1,   antiOx↑,11,   mt-antiOx↑,1,   AP-1↓,1,   ASK1↓,1,   AST↓,1,   ATP↑,3,   Aβ↓,2,   BACE↓,1,   Bax:Bcl2↓,1,   BBB↑,2,   BBB↝,1,   BDNF↑,2,   BioAv↓,2,   BioAv↑,7,   BP↓,1,   cardioP↑,3,   Casp3↓,1,   Casp3↑,1,   Catalase↑,5,   CDK5↓,1,   cognitive↑,5,   COX2↓,4,   CRP↓,1,   Dose↑,1,   Dose↝,1,   E-sel↓,1,   ECAR↓,1,   eff↑,1,   eff↝,1,   FOXO3↑,1,   GlucoseCon↓,1,   GlucoseCon↑,1,   Glycolysis↓,1,   Glycolysis↝,1,   GPx↑,1,   GPx1↑,1,   GSH↑,5,   GSK‐3β↓,1,   GSR↑,1,   hepatoP↑,2,   HK2↓,1,   HMGB1↓,1,   HO-1↑,6,   HSPs↑,1,   ICAM-1↓,1,   IFN-γ↑,1,   IKKα↑,1,   IL10↓,1,   IL10↑,1,   IL17↓,1,   IL1β↓,5,   IL23↓,1,   IL4↓,1,   IL6↓,4,   IL8↓,1,   Inflam↓,10,   iNOS↓,3,   Iron↓,1,   IronCh↑,1,   lactateProd↓,1,   LDHA↓,1,   LDL↓,3,   lipid-P↓,5,   MAPK↓,2,   MAPK↑,1,   MAPK↝,1,   MCP1↓,2,   MDA↓,3,   memory↑,6,   MMP↑,2,   MMPs↓,1,   MPO↓,1,   MPO↑,1,   mTOR↓,3,   p‑mTOR↓,1,   NADPH↓,13,   neuroP↑,8,   NF-kB↓,8,   NLRP3↓,4,   NO↓,1,   NOX↓,1,   NQO1↑,1,   NRF2↑,8,   OCR↑,1,   OS↑,1,   other↓,1,   P-gp↓,1,   p38↑,1,   PFK2↓,1,   PGE2↓,1,   PI3K↓,1,   PI3K↑,1,   PKCδ↓,1,   PPARα↑,1,   PPP↓,1,   Prx↑,1,   PSD95↑,1,   PTEN↓,1,   p‑Rac1↓,1,   radioP↑,1,   RAS↓,1,   RenoP↑,1,   ROS↓,17,   ROS↑,1,   mt-ROS↓,1,   Sepsis↓,4,   SIRT1↑,3,   SIRT2↑,1,   SIRT3↑,1,   SOD↑,4,   p‑tau↓,2,   TfR1/CD71↓,1,   TLR4↓,1,   TLR4↑,1,   TNF-α↓,6,   toxicity↓,2,   Trx↑,2,   TXNIP↓,1,  
Total Targets: 127

Scientific Paper Hit Count for: NADPH, Nicotinamide adenine dinucleotide phosphate
4 Hydrogen Gas
3 Quercetin
2 Curcumin
2 Honokiol
2 Silymarin (Milk Thistle) silibinin
1 2-DeoxyGlucose
1 Alpha-Lipoic-Acid
1 Artemisinin
1 Caffeic acid
1 Metformin
1 Chrysin
1 diet FMD Fasting Mimicking Diet
1 Huperzine A/Huperzia serrata
1 Methylene blue
1 Pterostilbene
1 Rosmarinic acid
1 Thymoquinone
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:624  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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