Database Query Results : , , cycA1

cycA1, cyclin A1: Click to Expand ⟱
Source:
Type:
Cyclin A1 is a protein that plays a crucial role in the regulation of the cell cycle, which is the process by which cells grow and divide. It is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer, and its overexpression has been linked to poor prognosis and reduced survival rates.
Scientific Papers found: Click to Expand⟱
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB↓, cycA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1↓, CycB↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB↓, cycA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
417- CUR,    Curcumin inhibits the growth of triple‐negative breast cancer cells by silencing EZH2 and restoring DLC1 expression
- vitro+vivo, BC, MCF-7 - vitro+vivo, BC, MDA-MB-231 - vitro+vivo, BC, MDA-MB-468
EZH2↓, DLC1↑, cycA1↓, CDK1↓, Bcl-2↓, Casp9↑, DLC1↑,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE↑, *cycA1↓, *CDK2↓,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27↑, cycA1↓, cycE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1↓, cycA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1↓, cycA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP↑, ROS↑, cMyc↓, cardioP↑,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
TumCP↓, TumCCA↑, cycA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
4537- MAG,    Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action
- in-vivo, Melanoma, NA - in-vitro, Melanoma, A431
*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB↓, cycA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1↓, CycB↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1↓, CycB↓, CDK2↓, P21↑, p27↑, hTERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
3256- PBG,    Mechanisms of Apoptosis and Cell Cycle Arrest Induced by Propolis in Cancer Therapy
- Review, Var, NA
TumCCA↑, CDK2↓, CDK4↓, cycA1↓, CycB↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1↓, CycB↓, cycE↓, cycD1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3415- TQ,    The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations
- in-vitro, Lung, H446
tumCV↓, TumCCA↑, ROS↓, CycB↑, CycD3↑, cycA1↓, cycE↓, cDC2↓, antiOx↑, PARP↓, NRF2↓, ARE/EpRE↑, eff↑,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1↓, cycD1↓, cycE↓, CDK2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Results for Effect on Cancer/Diseased Cells:
5LO↓,2,   ACC↑,1,   AIF↑,2,   Akt↓,8,   p‑Akt↓,1,   AMPK↑,2,   angioG↓,3,   antiOx↓,1,   antiOx↑,1,   AP-1↓,2,   Apoptosis↑,6,   ARE/EpRE↑,1,   ATF3↑,1,   ATF4↓,1,   ATF4↑,1,   ATG7↑,1,   BAD↑,2,   BAX↑,6,   Bax:Bcl2↑,2,   Bcl-2↓,7,   Bcl-xL↓,2,   Beclin-1↑,1,   BID↓,1,   BIM↑,1,   Ca+2↑,1,   i-Ca+2↑,1,   cardioP↑,1,   Casp3↑,7,   cl‑Casp3↑,2,   Casp7↑,1,   Casp8↑,4,   cl‑Casp8↑,2,   Casp9↑,6,   cl‑Casp9↑,2,   proCasp9↓,1,   CD44↓,1,   CDC2↓,3,   cDC2↓,1,   CDC25↓,5,   CDK1↓,6,   p‑CDK1↓,1,   CDK2↓,10,   CDK4↓,8,   CDK6↓,2,   cFLIP↓,1,   cFos↓,1,   ChemoSen↑,6,   CHK1↓,1,   Chk2↓,1,   CHOP↑,3,   cJun↓,1,   CLDN2↓,1,   cMET↓,1,   cMyc↓,3,   COX2↓,6,   COX2↑,1,   CSCs↓,1,   CXCL1↓,1,   CXCR4↓,2,   cycA1↓,18,   CycB↓,10,   CycB↑,1,   cycD1↓,7,   CycD3↑,1,   cycE↓,6,   CYP1B1↑,1,   Cyt‑c↑,8,   Diablo↑,2,   DLC1↑,3,   DNAdam↑,3,   DNMT1↓,1,   Dose?,1,   Dose↑,1,   Dose↝,1,   DR4↑,1,   DR5↓,1,   DR5↑,2,   E-cadherin↑,2,   E2Fs↓,1,   E6↓,1,   E7↓,1,   eff↓,3,   eff↑,10,   eff↝,1,   EGF↓,1,   EGFR↓,2,   eIF2α↓,1,   eIF2α↑,1,   EMT↓,2,   eNOS↓,1,   ER Stress↑,3,   ER-α36↓,1,   ER(estro)↓,1,   ERK↓,2,   p‑ERK↓,1,   EZH2↓,1,   Fas↑,2,   Fibronectin↓,1,   FOXO↑,1,   FOXO3↓,1,   FOXO3↑,1,   GlucoseCon↓,1,   GLUT1↓,1,   GRP78/BiP↑,1,   GSH↑,1,   GSK‐3β↓,2,   GSR↑,1,   GSTs↓,1,   GSTs↑,1,   H3↓,1,   H3↑,1,   HDAC↓,1,   HDAC1↓,1,   HER2/EBBR2↓,1,   HEY1↓,1,   Hif1a↓,3,   HK2↓,2,   HO-1↑,3,   HSP27↓,1,   HSP70/HSPA5↓,2,   HSP90↓,2,   hTERT↓,1,   IGF-1↓,1,   Igs↑,1,   IKKα↓,2,   IL1↓,1,   IL10↓,1,   IL12↓,2,   IL1α↓,1,   IL1β↓,1,   IL2↑,1,   IL6↓,3,   iNOS↓,1,   ITGA5↓,1,   JAK2↓,1,   JNK↑,1,   lactateProd↓,1,   LC3II↑,1,   LDHA↓,2,   lipid-P↓,1,   lipid-P↑,2,   LOX1↓,1,   MAPK↓,1,   MAPK↑,2,   Mcl-1↓,3,   MET↓,1,   mitResp↓,1,   MMP↓,8,   MMP1↓,1,   MMP2↓,6,   MMP3↓,1,   MMP7↓,2,   MMP9↓,7,   MMPs↓,2,   MPO↓,1,   mtDam↑,1,   mTOR↓,6,   mTORC1↓,1,   mTORC2↓,1,   Myc↓,2,   N-cadherin↓,4,   NADPH↑,1,   NF-kB↓,7,   NK cell↑,1,   NO↑,1,   NOTCH↓,2,   NQO1↑,1,   NRF2↓,2,   NRF2↑,1,   p16↑,1,   P21↑,12,   p27↑,5,   p38↓,1,   p38↑,3,   p50↓,1,   P53↑,8,   p65↓,2,   P70S6K↓,2,   p‑P70S6K↓,1,   p‑P90RSK↑,1,   PARP↓,2,   PARP↑,1,   cl‑PARP↑,5,   PCNA↓,2,   PDGFR-BB↓,1,   PERK↑,1,   PFK↓,1,   PI3K↓,6,   PKM2↓,1,   PPARγ↑,1,   PUMA↑,2,   RadioS↑,2,   p‑RB1↓,1,   RenoP↑,2,   ROS↓,3,   ROS↑,9,   ROS⇅,2,   ROS∅,1,   i-ROS↑,1,   p‑S6↓,1,   selectivity↑,3,   SIRT3↑,1,   Slug↓,3,   Snail↓,5,   SOD↑,1,   STAT3↓,4,   survivin↓,3,   TET2↑,1,   TLR4↓,1,   TNF-α↓,3,   TRAIL↑,1,   TS↓,1,   TumCCA↑,15,   TumCD↑,2,   TumCI↓,2,   TumCMig↓,3,   TumCP↓,6,   tumCV↓,2,   TumMeta↓,1,   Twist↓,3,   UHRF1↓,1,   uPA↓,3,   UPR↑,1,   VCAM-1↓,1,   VEGF↓,6,   VEGFR2↓,1,   Vim↓,4,   Wnt↓,3,   Wnt/(β-catenin)↓,1,   XIAP↓,2,   Zeb1↓,3,   α-tubulin↓,1,   β-catenin/ZEB1↓,3,   γH2AX↑,1,  
Total Targets: 234

Results for Effect on Normal Cells:
AntiAg↑,1,   antiOx↑,4,   Bax:Bcl2↑,1,   BioAv↓,1,   cardioP↑,2,   Casp3?,1,   Casp3↑,1,   Casp8↑,1,   cl‑Casp8↑,1,   Casp9↑,1,   CDK2↓,1,   cycA1↓,1,   cycE↑,1,   Fas↑,1,   FASN↓,1,   GSH↑,1,   hepatoP↑,2,   IL6↓,1,   IL8↓,1,   Inflam↓,4,   IronCh↓,1,   lipid-P↓,1,   MDA↓,1,   MMP↓,1,   neuroP↑,3,   NRF2↑,2,   p16↓,1,   P21↓,1,   P21↑,3,   P53↓,1,   P53↑,1,   PARP↑,1,   cl‑PARP↑,1,   Prx↑,1,   ROS↓,2,   ROS↑,1,   SOD2↑,1,   toxicity↓,1,   TumCCA↑,1,   tumCV↓,1,  
Total Targets: 40

Scientific Paper Hit Count for: cycA1, cyclin A1
3 Propolis -bee glue
3 Thymoquinone
2 Betulinic acid
2 Emodin
2 Fisetin
1 Apigenin (mainly Parsley)
1 Ashwagandha
1 Curcumin
1 Juglone
1 Magnolol
1 Quercetin
1 Sulforaphane (mainly Broccoli)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:653  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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