Database Query Results : , , γH2AX

γH2AX, gamma-H2AX: Click to Expand ⟱
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γH2AX (gamma-H2AX) is a histone protein that plays a crucial role in the repair of DNA double-strand breaks (DSBs). It is a phosphorylated form of the H2AX protein, which is a component of chromatin.

γH2AX is often used as a biomarker for DNA damage and genomic instability. When DNA is damaged, the H2AX protein is phosphorylated, forming γH2AX, which recruits and activates DNA repair proteins to the site of damage.
γ-H2AX, a marker for DNA double-strand breaks.

Cancer cells often exhibit increased levels of γH2AX due to their high rate of DNA replication and repair errors.

Gamma-H2AX, on the other hand, refers to a phosphorylated form of H2AX.
Scientific Papers found: Click to Expand⟱
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
591- Api,  doxoR,    Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
- in-vitro, AML, Jurkat - in-vitro, AML, THP1
ATP↓, Casp3↑, γH2AX↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
426- CUR,    Use of cancer chemopreventive phytochemicals as antineoplastic agents
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, CAL51
Bcl-2↓, ROS↑, BAX↑, RAD51↑, γH2AX↑,
474- CUR,    Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
3236- EGCG,  BA,    Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, HT29
Apoptosis↑, TumCCA?, HDAC1↓, DNMT1↓, survivin↓, HDAC↓, P21↑, NF-kB↑, γH2AX↑, ac‑H3↑, DNAdam↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
1657- HCAs,    Anticancer Activity of Sinapic Acid by Inducing Apoptosis in HT-29 Human Colon Cancer Cell Line 2023
- in-vitro, CRC, HT-29
cl‑Casp3↑, BAX↑, cl‑PARP↑, γH2AX↑, Cyt‑c↑,
2258- MFrot,  MF,    EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE
- in-vitro, GBM, GBM - in-vitro, Nor, SVGp12
TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,
3355- QC,    Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks
- in-vitro, Cerv, HeLa
DNAdam↑, ROS↑, *antiOx↑, TOP2↓, γH2AX↑,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,
2329- RES,    Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
- in-vitro, Melanoma, A375
P53↑, Bcl-2↓, BAX↑, Cyt‑c↑, ERK↓, PKM2↓, Apoptosis↑, γH2AX↑, Casp3↑, cl‑PARP1↑,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27↑, cycD1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
1460- SFN,    High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells
- in-vitro, Lung, NA
ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,
4400- SNP,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4406- SNP,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Results for Effect on Cancer/Diseased Cells:
AIF↑,1,   Akt↓,2,   ALAT↓,1,   AP-1↓,1,   Apoptosis↑,7,   AST↓,1,   ATF3↑,1,   ATF4↑,1,   ATM↑,1,   ATP↓,2,   BAD↑,1,   Bak↑,1,   BAX↓,1,   BAX↑,6,   Bax:Bcl2↑,1,   Bcl-2↓,7,   Beclin-1↓,1,   Beclin-1↑,1,   Casp3↑,4,   cl‑Casp3↑,5,   Casp8↑,1,   Casp9↑,2,   cl‑Casp9↑,3,   Catalase↓,1,   CD133↓,1,   CDC2↓,1,   CDC25↓,1,   CDK1↓,1,   CDK2↓,2,   CDK4↓,3,   CDK6↓,1,   cellSen↑,1,   ChemoSen↑,1,   CHK1↓,1,   p‑CHK1↑,1,   Chk2↓,1,   CHOP↑,1,   CK2↓,1,   cMyc↓,1,   COX2↓,2,   CSCs↓,1,   CXCR2↑,1,   cycA1↓,1,   CycB↓,1,   cycD1↓,1,   cycE↓,1,   Cyt‑c↑,4,   DNA-PK↑,2,   DNAdam↑,10,   DNMT1↓,1,   Dose↓,1,   Dose↝,1,   Dose∅,1,   DR4↑,1,   DR5↑,1,   E-cadherin↓,1,   E-cadherin↑,2,   E6↓,1,   E7↓,1,   eff↓,6,   eff↑,7,   EGFR↓,1,   EMT↓,2,   EpCAM↓,1,   ER Stress↑,1,   ER-α36↓,1,   ERK↓,1,   Fas↑,1,   FGF↓,1,   FGFR1↓,2,   FGFR2↓,1,   FOXO3↑,1,   Gli1↓,1,   GPx↓,1,   GSR↑,1,   H3↑,1,   ac‑H3↑,1,   HDAC↓,1,   HDAC1↓,1,   HEY1↓,1,   HO-1↑,1,   HSP90↓,1,   JAK↓,1,   lactateProd↓,1,   LC3‑Ⅱ/LC3‑Ⅰ↓,1,   LC3II↓,1,   LDHA↓,1,   lipid-P↑,2,   MAPK↑,1,   Mcl-1↓,1,   MGMT↓,1,   mitResp↓,1,   MMP↓,4,   MMP2↓,2,   MMP9↓,2,   MMPs↓,1,   mtDam↑,1,   N-cadherin↓,2,   NADPH↑,1,   NF-kB↓,1,   NF-kB↑,1,   NKG2D↑,1,   NOTCH↓,1,   NOTCH⇅,1,   NOTCH2↓,1,   NOXA↑,1,   NQO1↑,1,   NRF2↑,1,   OCR↑,1,   OS↑,2,   other↓,1,   other↝,1,   OV6↓,1,   P21↑,2,   p27↑,1,   p38↑,1,   P53↑,4,   PARP↑,2,   cl‑PARP↑,4,   cl‑PARP1↑,1,   PCNA↓,1,   PDGF↓,1,   PDGFR-BB↓,1,   p‑PDH↑,1,   PDK1↓,1,   PDKs↓,1,   PI3K↓,1,   PKM2↓,1,   PTCH1↓,1,   PTEN↑,1,   PUMA↑,1,   RAD51↓,1,   RAD51↑,1,   RadioS↑,2,   p‑RB1↓,1,   RenoP↑,1,   ROS↑,14,   selectivity↑,5,   SIRT3↑,1,   Slug↓,1,   p‑SMAD2↓,1,   p‑SMAD3↓,1,   Smo↓,1,   Snail↓,2,   SOD↓,1,   SOX4↓,1,   STAT3↓,2,   p‑STAT3↓,1,   STAT5↓,1,   survivin↓,2,   SVCT-2∅,1,   TAC?,1,   TIMP1↑,2,   TIMP2↑,1,   TOP2↓,1,   TumCCA?,1,   TumCCA↑,9,   TumCD↑,4,   TumCG↓,2,   TumCMig↓,3,   TumCP↓,3,   tumCV↓,2,   TumVol↓,1,   tyrosinase↓,1,   uPA↓,1,   VEGF↓,2,   Vim↓,3,   Wnt↓,1,   β-catenin/ZEB1↓,2,   γH2AX↑,21,  
Total Targets: 170

Results for Effect on Normal Cells:
antiOx↑,1,   BioAv↓,1,   Casp3?,1,   Prx↑,1,   SOD2↑,1,   toxicity↓,2,   toxicity∅,2,  
Total Targets: 7

Scientific Paper Hit Count for: γH2AX, gamma-H2AX
3 Resveratrol
2 Curcumin
2 Quercetin
2 Sulforaphane (mainly Broccoli)
2 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 doxorubicin
1 Ashwagandha
1 Berberine
1 Dichloroacetate
1 Metformin
1 EGCG (Epigallocatechin Gallate)
1 Butyrate
1 Ferulic acid
1 Hydroxycinnamic-acid
1 Magnetic Field Rotating
1 Magnetic Fields
1 Radiotherapy/Radiation
1 Vitamin C (Ascorbic Acid)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:667  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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