Database Query Results : , , MDR1

MDR1, Multidrug Resistance 1: Click to Expand ⟱
Source:
Type: gene
MDR-1 (Multidrug Resistance 1) is a gene that plays a crucial role in the development of resistance to chemotherapy in cancer cells. The MDR-1 gene encodes for a protein called P-glycoprotein (P-gp), which is a transmembrane efflux pump that helps to remove toxic substances, including chemotherapy drugs, from cells.
MDR-1 is often overexpressed in various types of cancer, including: Leukemia, Lymphoma, Breast, Lung, Ovarian, CRC.
Scientific Papers found: Click to Expand⟱
1397- BBR,  Chemo,    Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
- in-vitro, Lung, A549
TumCG↓, ROS↑, MDR1↓,
2803- CHr,  5-FU,    Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells
- in-vitro, GC, AGS
ChemoSen↑, TumCCA↑, eff↑, MDR1↓,
466- CUR,    Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1
- in-vitro, Liver, HepG2 - in-vitro, Liver, HuT78
GlucoseCon↓, lactateProd↓, pH↑, NO↑, LAR↓, Hif1a↓, LDHA↓, MCT1↓, MDR1↓, STAT3↓, HCAR1↓,
1057- EDM,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
NF-kB↓, TNF-α↓, COX2↓, cycD1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2↓, cFLIP↓, Bfl-1↓,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
2179- itraC,    Repurposing itraconazole for the treatment of cancer
- Review, Var, NA
HH↓, angioG↓, TumCCA↑, MDR1↓, P-gp↓, mTOR↓, VEGF↓, Smo↓, Gli1↓, OS↑, PSA↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1↓, CycB↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
3327- SIL,    Effects of silymarin on HIF‑1α and MDR1 expression in HepG‑2 cells under hypoxia
- in-vitro, Liver, HepG2
MDR1↓, Hif1a↓, P-gp↓,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Results for Effect on Cancer/Diseased Cells:
AEG1↓,1,   Akt↓,3,   p‑Akt↓,1,   ALDH↓,1,   AMPK↑,1,   angioG↓,6,   antiOx↑,1,   AP-1↓,1,   Apoptosis↑,3,   AR↓,2,   ATF4↝,1,   BAX↑,3,   Bax:Bcl2↑,1,   Bcl-2↓,3,   Bcl-xL↓,1,   Bfl-1↓,1,   BioAv↓,2,   BioAv↑,5,   BioEnh↑,1,   Ca+2↑,2,   cardioP↑,1,   Casp↑,1,   Casp3↑,2,   cl‑Casp3↑,1,   Casp7↑,2,   cl‑Casp8↑,1,   Casp9↑,2,   cl‑Casp9↑,1,   CD44↓,1,   CDC2↓,1,   CDK2↓,1,   CDK4↓,1,   CDK6↓,1,   cFLIP↓,1,   chemoP↑,2,   chemoR↓,1,   ChemoSen↓,1,   ChemoSen↑,6,   ChemoSen⇅,1,   ChemoSideEff↓,1,   CHOP↑,1,   cMyc↓,3,   p‑cMyc↑,1,   COX2↓,5,   CSCs↓,2,   CXCR4↓,3,   CycB↓,1,   cycD1↓,3,   Cyt‑c↑,1,   DFF45↓,1,   DNAdam↑,4,   DNMT1↓,1,   Dose↝,2,   DR5↑,1,   E-cadherin↑,2,   eff↑,7,   EMT↓,3,   ER Stress↑,2,   ERK↓,1,   FAK↓,1,   Fenton↑,1,   FOXO4↑,1,   Gli1↓,1,   GlucoseCon↓,1,   Glycolysis↓,1,   GSH↓,1,   GSK‐3β↓,1,   p‑GSK‐3β↓,1,   Half-Life↝,3,   HCAR1↓,1,   HH↓,3,   Hif1a↓,4,   HK2↓,2,   HO-1↓,1,   HO-1↑,1,   hTERT↓,1,   IAP1↓,1,   IAP2↓,1,   ICAM-1↓,2,   IFN-γ↓,1,   IL6↓,2,   Inflam↓,1,   iNOS↓,1,   JNK↑,1,   lactateProd↓,1,   LAR↓,1,   LC3B-II↑,1,   LDHA↓,1,   MALAT1↓,1,   MCT1↓,1,   MDM2↓,1,   MDR1↓,15,   MMP↓,1,   MMP13↓,1,   MMP2↓,1,   MMP7↓,2,   MMP9↓,4,   MMPs↓,2,   MRP1↓,1,   mTOR↓,4,   Myc↓,1,   N-cadherin↓,1,   NADPH↓,1,   Nanog↓,1,   Nestin↓,1,   NF-kB↓,5,   p‑NF-kB↑,1,   NICD↓,1,   NO↑,1,   NOTCH1↓,1,   NRF2↓,2,   NRF2↑,2,   OS↑,1,   P-gp↓,4,   P21↓,1,   P21↑,3,   P450↓,1,   P53↑,3,   cl‑PARP↑,2,   pH↑,1,   PI3K↓,1,   PKM2↓,1,   Prx4↑,1,   PSA↓,1,   PTEN↑,3,   RadioS↑,5,   RAS↓,2,   p‑RB1↓,1,   RIP1↑,1,   RIP3↑,1,   ROS↓,1,   ROS↑,7,   selectivity↑,3,   Shh↓,1,   SIRT1↓,1,   SIRT2↓,1,   Slug↓,1,   Smo↓,1,   SOX4↑,1,   Sp1/3/4↓,1,   Src↓,1,   STAT1↓,1,   STAT3↓,3,   STAT6↓,1,   survivin↓,3,   TAZ↓,1,   TCF↓,1,   Telomerase↓,1,   TIMP1↑,1,   TIMP2↑,2,   TNF-α↓,1,   TOP2↓,1,   toxicity↝,1,   TP53↑,1,   TRAIL↑,1,   TrxR↓,1,   TumAuto↑,2,   TumCCA↑,4,   TumCG↓,1,   TumCI↓,1,   TumCP↓,4,   TumMeta↓,4,   Twist↓,1,   uPA↓,1,   VEGF↓,7,   VEGFR2↓,1,   Vim↓,1,   Wnt↓,2,   XBP-1↑,1,   XIAP↓,1,   YAP/TEAD↓,1,   β-catenin/ZEB1↓,2,  
Total Targets: 172

Results for Effect on Normal Cells:
AChE↓,1,   angioG↑,1,   antiOx↑,2,   AP-1↓,1,   BioAv↓,2,   BioAv↑,6,   BP↓,1,   cardioP↑,1,   CardioT↓,1,   cognitive↑,1,   COX2↓,1,   CRP↓,1,   eff↑,2,   ERK↓,1,   GSH↑,1,   H2O2↑,1,   HO-1↑,2,   ICAM-1↓,1,   IFN-γ↑,1,   IL1β↓,1,   IL6↓,1,   Inflam↓,1,   IronCh↑,1,   JNK↓,1,   lipid-P↓,1,   MAPK↓,1,   MDA↓,1,   memory↑,2,   neuroP↑,2,   NF-kB↓,1,   NLRP3↓,1,   NRF2↑,1,   PKCδ↓,1,   ROS↓,3,   SIRT1↑,1,   SOD↑,1,   TLR4↑,1,   TNF-α↓,1,   toxicity↓,1,  
Total Targets: 39

Scientific Paper Hit Count for: MDR1, Multidrug Resistance 1
2 itraconazole
2 Luteolin
1 Berberine
1 Chemotherapy
1 Chrysin
1 5-fluorouracil
1 Curcumin
1 Evodiamine
1 Piperlongumine
1 Quercetin
1 Resveratrol
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Thymoquinone
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:741  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page