Database Query Results : , , other

other, other: Click to Expand ⟱
Source:
Type:
custom
Scientific Papers found: Click to Expand⟱
1339- 2DG,  Cisplatin,    2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells
- in-vitro, HNSCC, FaDu
ChemoSen↑, ROS↑, GSH↓, other↓,
1336- 2DG,    2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
- in-vitro, GBM, SK-N-SH
ROS↑, GlucoseCon↓, other↓,
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
543- Akk,    Dynamic Changes of the Gut Microbiota and Its Functional Metagenomic Potential during the Development of Non-Small Cell Lung Cancer
other↓,
551- AL,    The Influence of Heating on the Anticancer Properties of Garlic
- Analysis, NA, NA
other↓,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
3817- Aroma,    Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms
- Review, AD, NA
*BChE↓, *AChE↓, *other↓, *other?, *Ach?, *eff↑, *antiOx↑, *ROS↓, *cognitive↑, *Mood↑, *Sleep↑,
3821- Aroma,    Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants
- Review, AD, NA
*cognitive↑, *AChE↓, *BChE↓, *ROS↓, *other↓, *other↓, *other↓, *other↓, *other↓, *memory↑, *BACE↓, *Mood↑, *motorD↑,
3822- Aroma,    Aromatherapy in the treatment of Alzheimer's disease: A systematic review
- Review, AD, NA
*cognitive↑, *other↑, *other↓, *BioAv↑, *BBB?,
1355- Ash,    Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, HMEC
eff↑, mt-ROS↑, mitResp↓, OXPHOS↓, compIII↑, BAX↑, Bak↑, other↓, ATP∅, *ROS∅,
2598- Ba,    Baicalein inhibits melanogenesis through activation of the ERK signaling pathway
- in-vitro, Melanoma, B16-F10
other↓, other?, ERK↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
728- Bor,    Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
other↓,
761- Bor,    Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study
- Study, BPH, NA
other↓,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
4773- CoQ10,    Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway
- in-vitro, Nor, NA
*other↓, *PI3K↑, *Akt↑, *mTOR↑, *ROS↓,
3627- Croc,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
3760- CUR,  GI,  CAP,  RosA,  PI  Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment
*AChE↓, *other↓, *other↓, *other↓, *other↓, *other↓, *other↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
4143- Ex,    Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, *eff↑, *other↓, *eff↑,
3719- GABA,    Treatment Options in Alzheimer´s Disease: The GABA Story
- Review, AD, NA
*other↓,
792- GE,    The role of germanium in diseases: exploring its important biological effects
other↓,
790- GE,    A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
- vitro+vivo, NA, NA
other↓,
941- Gos,  Rad,    The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis
- in-vivo, NA, NA
lactateProd↓, other↓, TGF-β↓,
842- Gra,    Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)
- in-vitro, NA, NA - in-vitro, Nor, NA
other↓, *toxicity↓,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
1635- HCA,    Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway
- vitro+vivo, Nor, NA
*other↓, *ROS↓, *SOD↑, *Catalase↑, *MDA↓, *NRF2↑,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
1628- HCA,  ALA,    Addition of Hydroxy Citrate improves effect of ALA
- Review, Var, NA
ACLY↓, other↓, ROS↑, eff↑, PDKs↓,
1439- HCQ,    Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine
- in-vitro, Melanoma, NA - in-vitro, CRC, HCT116
TumAuto↓, eff↓, other↓,
1925- JG,    Redox regulation of mitochondrial functional activity by quinones
- in-vitro, NA, NA
other↓, ROS↑, MMP↓, eff↝,
4014- K+,    The effects of boiling and leaching on the content of potassium and other minerals in potatoes
- Analysis, NA, NA
*other↓, *eff↑, *other↓,
4006- K+,    Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid
- in-vitro, AD, NA
*other↓,
862- Lae,    Molecular mechanism of amygdalin action in vitro: review of the latest research
- Review, NA, NA
BAX↑, Casp3↑, Bcl-2↓, Akt↓, mTOR↓, p19↑, TumCCA↑, other↓,
4293- LT,    Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *p‑mTOR↓, *p‑NF-kB↓, *HDAC2↓, *BDNF↑, *other↓, *p‑tau↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4195- Lut,  Zeax,    Low Xanthophylls, Retinol, Lycopene, and Tocopherols in Grey and White Matter of Brains with Alzheimer’s Disease
- Human, AD, NA
*Risk↓, *cognitive↑, *other↓,
3984- Lut,  VitE,    Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: A case-control study
- Study, AD, NA
*other↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
585- MF,  VitC,    Impact of pulsed magnetic field treatment on enzymatic inactivation and quality of cloudy apple juice
other↓,
587- MF,  VitC,    Effect of stationary magnetic field strengths of 150 and 200 mT on reactive oxygen species production in soybean
ROS↑, SOD↓, other↓,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
229- MFrot,  MF,    Molecular mechanism of effect of rotating constant magnetic field on organisms
- in-vivo, Nor, NA
*NO↑, *5HT↓, *eff↝, *eff↝, *β-Endo↑, *other↓,
787- Mg,    Magnesium and Human Health: Perspectives and Research Directions
VitD↑, other↓,
781- Mg,    Hypomagnesemia in the Cancer Patient
- Analysis, NA, NA
other↓,
3759- NarG,  RT,  CGA,  RosA,    Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease
- Review, AD, NA
AChE↓, *other↓, *other↓,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3377- QC,    Quercetin inhibits a large panel of kinases implicated in cancer cell biology
PDGF↓, FLT3↓, JAK3↓, MET↓, RET↓, FGFR2↓, other↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
909- QC,    Exploring the therapeutic potential of quercetin in cancer treatment: Targeting long non-coding RNAs
- Review, NA, NA
other↓, other↑,
871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
T-Cell↑, Neut↓, Macrophages↓, ROS↑, MMP↓, other↓, AntiTum↑, TumVol↓,
880- RES,    Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
- in-vitro, BC, MDA-MB-231
other↓, TumW↓, FOXO↑, BMP2↑,
881- RES,    Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1 - in-vitro, Pca, DU145
TumCCA↑, cycD1/CCND1↓, Bcl-xL↓, Mcl-1↓, other↓,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
3015- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROS/MYPT1/TGFβ1 Signaling Via miR-19b-3p
- in-vivo, Nor, IMR90
*radioP↑, *Inflam↓, *ROS↓, *NF-kB↓, *Rho↓, *ROCK1↓, *other↓,
4494- Se,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, OS↑, *CRP↓, *GPx↑, *Inflam↓, *ROS↓, *GutMicro↑, *selenoP↑, *other↓,
4727- Se,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,
4742- Se,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
4609- Se,    Physiological Benefits of Novel Selenium Delivery via Nanoparticles
- Review, Var, NA - Review, IBD, NA - Review, Diabetic, NA
*selenoP↑, Risk↓, AntiCan↑, ROS↑, *Dose↝, *toxicity↓, *BioAv↑, *GutMicro↑, *other↓,
2168- SFN,    Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model
- in-vivo, AD, NA
*NRF2↑, *cognitive↑, other↓,
4122- Silicon,    Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's disease
- Trial, AD, NA
*other↓, *other∅, *cognitive↑,
4127- Silicon,    Interference of Parenteral Nutrition Components in Silicon-Mediated Protection Against Aluminum Bioaccumulation
- in-vivo, AD, NA
*other↓, *neuroP↑,
4131- Silicon,    Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease
- Study, Nor, NA
*other↓, *BioAv↓, *neuroP↑,
2193- SK,    Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition
- in-vitro, Nor, HMVEC-dLy
*NF-kB↓, *Hif1a↓, other↓,
4406- SNP,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
3562- TQ,    ACETYLCHOLINESTERASE AND GROWTH INHIBITORY EFFECTS–VARIOUS GRADES OF N. SATIVA OILS
- Review, AD, NA - Review, Var, NA
*AChE↓, *other↓,
4066- VitB12,  VitB6,  FA,    Vitamin B6, B12, and Folate’s Influence on Neural Networks in the UK Biobank Cohort
- Study, AD, NA
*other↓, *other↑, *other↑,
4032- VitB3,    Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer's Disease
- in-vivo, AD, NA
*DNAdam↓, *Inflam↓, *other↓, *cognitive↑, *Mood↑,
634- VitC,    Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
- Analysis, NA, NA
other↓, iNOS↓, eNOS↑,
580- VitC,  MF,    Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum
- in-vivo, Nor, NA
*other↓, *MDA↓, *GPx∅, *SOD↑, *GSH∅,
1215- VitC,  immuno,    Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma
- ex-vivo, HCC, NA - in-vivo, HCC, NA
other↓, *GPx4↑, *GSH↑, GPx4↓, GSH↓, selectivity↑,
3102- VitC,    Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
- Review, Var, NA - Review, Stroke, NA
*radioP↑, *Dose↝, ROS↑, *neuroP↑, other↓, *ROS↓, *MMP↑,
4091- VitK2,    The possible role of vitamin K deficiency in the pathogenesis of Alzheimer's disease and in augmenting brain damage associated with cardiovascular disease
- Review, AD, NA
*cognitive↑, *other↓, *cardioP↑,
1756- WBV,    Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
- in-vitro, MB, A431
Apoptosis↑, GlucoseCon↝, other↓,
1754- WBV,    Vibration Therapy for Cancer-Related Bone Diseases
- Review, Var, NA
*BMD↑, *toxicity∅, other↓, Dose↝, Dose↑, eff↑, eff↑, eff↑,
1750- WBV,    Whole body vibration exercise in the management of cancer therapy-related morbidities: A systematic review
- Review, Var, NA
Wmax↑, UrinaryC↑, other↓, other↓, Dose?,
4197- Z,    The Effect of Zinc Supplementation on Circulating Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, NA, NA
*BDNF↑, *other↓, *eff↑, *Inflam↓, *antiOx↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 82

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 3,   HO-1↑, 1,   OXPHOS↓, 1,   Prx↓, 1,   ROS↑, 17,   mt-ROS↑, 1,   SOD↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ATP∅, 1,   CDC25↓, 2,   compIII↑, 1,   mitResp↓, 1,   MMP↓, 6,   MMP↑, 1,   OCR↑, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 2,   AMPK↑, 5,   cMyc↓, 1,   ECAR↓, 1,   FASN↓, 1,   FDG↓, 1,   GlucoseCon↓, 1,   GlucoseCon↝, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   homoC↓, 1,   lactateProd↓, 2,   NADPH↑, 1,   PDH↑, 1,   PDKs↓, 1,   PFK1↓, 1,   PFK2↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 8,   Bak↑, 2,   BAX↑, 6,   Bcl-2↓, 4,   Bcl-xL↓, 4,   BMP2↑, 1,   Casp↑, 2,   Casp10↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 2,   Cyt‑c↝, 1,   DR5↑, 2,   Fas↑, 3,   FasL↑, 1,   HGF/c-Met↓, 1,   IAP1↓, 1,   iNOS↓, 2,   JNK↑, 3,   MAPK↓, 3,   Mcl-1↓, 2,   MDM2↓, 1,   p27↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAILR↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

RET↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

other?, 1,   other↓, 44,   other↑, 1,   other↝, 2,   tumCV↓, 1,   UrinaryC↑, 1,   Wmax↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 2,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DFF45↑, 1,   DNAdam↑, 1,   DNMTs↓, 1,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   p19↑, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   EMT↑, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↓, 1,   FGFR2↓, 1,   FLT3↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 4,   NOTCH1↓, 1,   PI3K↓, 3,   PTEN↑, 2,   RAS↓, 1,   STAT3↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 4,  

Migration ⓘ

Ca+2↝, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↓, 2,   LEF1↓, 1,   MET↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 2,   PDGF↓, 2,   PKCδ↓, 1,   RAGE↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 2,   SOX4↓, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 3,   EGR4↓, 1,   eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   VEGF↓, 2,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 3,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 2,   JAK3↓, 1,   Macrophages↓, 1,   MCP1↓, 1,   Neut↓, 1,   NF-kB↓, 5,   PGE2↓, 1,   T-Cell↑, 1,   TNF-α↓, 2,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↝, 1,   ChemoSen↑, 5,   CYP1A2↓, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 2,   eff↓, 1,   eff↑, 7,   eff↝, 2,   Half-Life↓, 1,   P450↓, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 3,   IL6↓, 2,   RAGE↓, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 3,   chemoP↑, 3,   neuroP↑, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 221

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 11,   Catalase↑, 5,   Ferroptosis↓, 1,   GPx↑, 3,   GPx∅, 1,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 3,   GSH∅, 1,   GSR↑, 1,   GSTA1↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↓, 1,   lipid-P↓, 5,   MDA↓, 5,   NRF2↑, 7,   RNS↓, 1,   ROS↓, 18,   ROS∅, 1,   mt-ROS↓, 1,   selenoP↑, 2,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 5,   SOD1↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,   LDL↓, 2,   NADPH↓, 2,   PPARα↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   MAPK↝, 1,  

Transcription & Epigenetics ⓘ

Ach?, 1,   Ach↑, 1,   other?, 1,   other↓, 50,   other↑, 5,   other↝, 1,   other∅, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   FOXO3↑, 1,   HDAC2↓, 1,   IGF-1R↓, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↑, 1,   PTEN↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   E-sel↓, 1,   MMP2↓, 1,   MMPs↓, 1,   Rho↓, 1,   ROCK1↓, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   NO↓, 1,   NO↑, 1,   PDGFR-BB↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 1,   CD69↓, 1,   COX2↓, 3,   CRP↓, 1,   CTLA-4↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL17↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL4↓, 2,   IL6↓, 3,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 14,   JAK↓, 1,   MCP1↓, 1,   NF-kB↓, 4,   p‑NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission other neurodegenerative diseases." style="cursor:help;color:#555;font-weight:normal;">ⓘ

5HT↓, 1,   AChE↓, 5,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 1,   monoA↑, 1,   p‑tau↓, 1,  

Protein Aggregation other aggregation disorders." style="cursor:help;color:#555;font-weight:normal;">ⓘ

Aβ↓, 1,   BACE↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 7,   BioAv↝, 2,   Dose↝, 3,   eff↑, 8,   eff↝, 2,   Half-Life↓, 2,   Half-Life↝, 1,  

Clinical Biomarkers otherapy eligibility | Immunotherapy | Gatekeeper for checkpoint use | | 5 | MSI | Tumor-agnostic immunotherapy | Immunotherapy | One of the strongest predictors of IO response | | 6 | BRAF | Targeted therapy | Target selection | Direct, mutation-specific action | | 7 | BRCA1 / BRCA2 | PARP inhibitor use | Target selection | Therapy + inherited risk | | 8 | ALK | Fusion-targeted therapy | Target selection | Dramatic response when positive | | 9 | AR | Prostate therapy backbone | Target selection | Defines entire disease class | | 10 | ESR1 | Endocrine therapy | Target selection | Absolute requirement in breast cancer | Mid-Tier: Strong but Contextual Decision Impact | Rank | Biomarker | Primary Use | Clinical Class | Notes | | ---- | ------------- | ----------------------- | ---------------- | ----------------------------- | | 11 | NTRK (fusion) | Tumor-agnostic therapy | Target selection | Rare but decisive | | 12 | PSA | Monitoring, progression | Monitoring | Drives treatment timing | | 13 | B2M | Staging & prognosis | Immunotherapy | Used in myeloma/lymphoma | | 14 | TP53 | Risk stratification | Aggressiveness | Alters intensity, trials | | 15 | WT1 | MRD monitoring | Monitoring | Highly actionable in leukemia | | 16 | Ki-67 | Growth rate | Aggressiveness | Influences therapy escalation | | 17 | CA-125 | Therapy response | Monitoring | Standard ovarian tracking | | 18 | CEA | Recurrence detection | Monitoring | Common but nonspecific | Lower-Tier: Indirect / Emerging / Contextual Impact | Rank |Biomarker| Primary Role | Clinical Class | Why Lower | | ---- | ------- | ---------------------- | ---------------- | -------------------------- | | 19 | AFP | Diagnosis/monitoring | Monitoring | Cancer-specific contexts | | 20 | CA 19-9 | Disease burden | Monitoring | Prognostic, not directive | | 21 | MYC | Risk biology | Aggressiveness | Not directly actionable | | 22 | TERT | Prognosis | Aggressiveness | Rarely changes therapy | | 23 | EZH2 | Epigenetic state | Aggressiveness | Select indications | | 24 | SUZ12 | PRC2 dependency | Aggressiveness | Indirect | | 25 | RBM3 | Prognostic | Aggressiveness | Informative, not directive | | 26 | OPG | Bone microenvironment | Microenvironment | Supportive info | | 27 | RAGE | Inflammation state | Microenvironment | Research-stage | | 28 | XIST | Epigenetic instability | Aggressiveness | Not yet clinical | | 29 | FOXM1 | High-risk biology | Aggressiveness | No routine testing | | 30 | TRIB3 | Stress adaptation | Aggressiveness | Mechanistic, not clinical | Core Liver & Systemic Biomarkers in Oncology | Marker | What It Reflects | Main Use in Cancer | Decision Impact | | --------- | ----------------------------------- | ----------------------------------------- | ----------- | | ALT | Hepatocellular injury | Baseline eligibility, toxicity monitoring | High | | AST | Liver + systemic injury | Detect liver injury, muscle involvement | High | | ALP | Cholestasis, bone turnover | Liver mets vs bone mets | High | | bilirubin | Hepatic clearance | Chemotherapy dosing | Critical | | albumin | Synthetic liver function, nutrition | Prognosis, frailty | High | | LDH | Tumor burden, hypoxia | Aggressiveness, prognosis | High | | INR | Liver synthetic failure | Treatment safety | High | Key Inflammatory / Host-Response Biomarkers Used in Oncology | Biomarker | What It Reflects | Main Use in Cancer | Clinical Decision Impact | | ------------------ | -------------------------------- | ---------------------------- | -------------------- | | C-reactive protein | Systemic inflammation | Prognosis, therapy tolerance | High | | ESR | Chronic inflammation | Disease activity trend | Moderate | | ferritin | Inflammation + iron status | Cachexia, cytokine load | High | | IL-6 | Cytokine signaling | Aggressiveness, cachexia | High (specialty use) | | LDH | Tumor burden + hypoxia | Risk stratification | Very high | | albumin | Nutritional & inflammatory state | Frailty, survival | Very high | </pre> " style="cursor:help;color:#555;font-weight:normal;">ⓘ

BMD↑, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 3,   cognitive↑, 13,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 5,   Mood↑, 3,   motorD↑, 1,   neuroP↑, 9,   Pain↓, 1,   radioP↑, 2,   Risk↓, 2,   Sleep↑, 1,   toxicity↓, 3,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 134

Scientific Paper Hit Count for: other, other
7 Vitamin C (Ascorbic Acid)
5 Magnetic Fields
5 Quercetin
4 Rosmarinic acid
4 Selenium
3 Vitamin B12
3 Folic Acid
3 Aromatherapy
3 HydroxyCitric Acid
3 Resveratrol
3 Silicic Acid
3 Whole Body Vibration
2 2-DeoxyGlucose
2 Alpha-Lipoic-Acid
2 Boron
2 Capsaicin
2 Curcumin
2 Piperine
2 Germanium
2 Radiotherapy/Radiation
2 Potassium
2 Luteolin
2 Lutein
2 Magnesium
1 Cisplatin
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Akkermansia
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Berberine
1 Celastrol
1 Chemotherapy
1 Citric Acid
1 Coenzyme Q10
1 Crocetin
1 Ginger/6-Shogaol/Gingerol
1 EGCG (Epigallocatechin Gallate)
1 Exercise
1 Gamma-aminobutyric acid
1 Gossypol
1 Graviola
1 Hydrogen Gas
1 hydroxychloroquine
1 Juglone
1 Laetrile B17 Amygdalin
1 Zeaxanthin
1 Vitamin E
1 Methylene blue
1 Magnetic Field Rotating
1 Naringin
1 Rutin
1 Chlorogenic acid
1 Pterostilbene
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Silver-NanoParticles
1 Thymoquinone
1 Vitamin B6,pyridoxine
1 Vitamin B3,Niacin
1 immunotherapy
1 Vitamin K2
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:767  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page