Database Query Results : , , E7

E7, E7: Click to Expand ⟱
Source:
Type: oncoprotein
E7 is a protein encoded by the human papillomavirus (HPV) genome, specifically by the high-risk HPV types 16 and 18. E7 is a key oncoprotein that plays a crucial role in the development and progression of cervical cancer, as well as other HPV-related cancers.
E7 is often used as a biomarker for HPV-related cancers, and its detection can help diagnose and monitor the progression of these cancers.
Scientific Papers found: Click to Expand⟱
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
682- EGCG,    Suppressive Effects of EGCG on Cervical Cancer
- Review, NA, NA
E7↓, E6↓, PI3K/Akt↓, P53↑, p27↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Results for Effect on Cancer/Diseased Cells:
Akt↓,4,   p‑Akt↓,1,   ALDH1A1↓,1,   angioG↓,1,   antiOx↓,1,   AP-1↓,2,   Apoptosis↑,1,   ATF3↑,1,   ATF4↑,1,   Bak↑,1,   BAX↑,3,   Bcl-2↓,2,   Bcl-2↑,1,   BIM↑,1,   BioAv↝,1,   Casp↑,2,   Casp3↑,3,   cl‑Casp3↑,1,   cl‑Casp9↑,1,   CD44↓,1,   CDC2↓,1,   CDC2↑,1,   CDK1↓,2,   CDK2↓,2,   CDK4↓,2,   CHK1↓,1,   Chk2↓,1,   CHOP↑,3,   cMET↓,1,   cMyc↓,1,   COX2↓,2,   CRP↓,1,   CSCs↓,2,   cycA1↓,1,   CycB↓,1,   CycB↑,1,   cycE↓,1,   Cyt‑c↑,2,   DNAdam↑,1,   Dose↝,1,   Dose∅,1,   DR5↑,2,   E6↓,7,   E7↓,7,   eff↑,5,   EGFR↓,1,   eIF2α↓,1,   EMT↓,2,   EMT↑,1,   ER Stress↑,1,   ER-α36↓,1,   ERK↓,2,   p‑ERK↓,1,   FASN↓,1,   Ferroptosis↑,1,   FOXO3↑,1,   Glycolysis↓,2,   GPx↑,1,   GPx4↓,1,   GSR↑,1,   H3↑,1,   Half-Life↝,1,   HEY1↓,1,   HIF-1↓,1,   Hif1a↓,1,   HO-1↑,2,   HSP90↓,4,   IFN-γ↓,1,   IGF-1↓,1,   IL1β↓,1,   IL6↓,1,   Inflam↓,1,   iNOS↓,1,   Iron↑,1,   lactateProd↓,1,   LDHA↓,1,   lipid-P↓,1,   lipid-P↑,2,   MAPK↑,2,   Mcl-1↓,1,   mitResp↓,1,   MMP↓,2,   MMP2↓,2,   MMP9↓,2,   MMPs↓,1,   MPT↑,1,   mTOR↓,2,   mTOR⇅,1,   N-cadherin↓,1,   NADPH↑,1,   Nanog↓,1,   NF-kB↓,4,   NO↓,1,   NOTCH↓,1,   NOTCH1↓,2,   NQO1↑,1,   NRF2↑,1,   P21↑,3,   p27↑,1,   p38↓,1,   p38↑,2,   P53↑,5,   PARP↑,1,   cl‑PARP↑,1,   PCNA↓,1,   PDGFR-BB↓,1,   PDK1↓,1,   PI3K↓,1,   PI3K/Akt↓,1,   PPARγ↑,1,   pRB↑,1,   PTEN↑,1,   p‑RB1↓,1,   RenoP↑,1,   RET↓,1,   ROS↑,4,   ROS⇅,1,   selectivity↑,1,   SIRT3↑,1,   Slug↓,1,   Snail↓,1,   SOD↑,1,   SOX2↓,1,   STAT3↓,3,   TCA↓,1,   TGF-β↓,1,   TNF-α↓,2,   TSC1↑,1,   TumCCA↑,2,   TumCD↑,1,   TumCP↓,1,   Twist↓,1,   uPA↓,2,   VEGF↓,3,   Vim↓,2,   Wnt↓,2,   β-catenin/ZEB1↓,2,   γH2AX↑,1,  
Total Targets: 138

Results for Effect on Normal Cells:
BioAv↓,1,   BioAv↑,1,   BioEnh↑,1,   Casp3?,1,   GSH↑,1,   Half-Life∅,1,   hepatoP↑,1,   NRF2↑,1,   Prx↑,1,   SOD2↑,1,   toxicity↓,1,  
Total Targets: 11

Scientific Paper Hit Count for: E7, E7
4 Ashwagandha
1 alpha Linolenic acid
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:840  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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