Database Query Results : , , cFLIP

cFLIP, cellular FLICE-like inhibitory protein: Click to Expand ⟱
Source:
Type: protein
c-FLIP (cellular FLICE-like inhibitory protein) also know as FLIP
- is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death.
It is a key regulator of the extrinsic pathway of apoptosis, which is mediated by death receptors such as Fas and TNF-R1.
c-FLIP is a pseudokinase that can inhibit the activation of caspase-8, a key enzyme in the extrinsic pathway of apoptosis. By inhibiting caspase-8 activation, c-FLIP can prevent the initiation of the apoptotic cascade and promote cell survival.
In cancer, c-FLIP is often overexpressed, which can contribute to the development and progression of the disease.
Scientific Papers found: Click to Expand⟱
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
1057- EDM,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
NF-kB↓, TNF-α↓, COX2↓, cycD1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2↓, cFLIP↓, Bfl-1↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, Foxm1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
2884- HNK,    Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP
- in-vitro, Lung, A549 - in-vitro, Lung, H460
EMT↓, cFLIP↓, N-cadherin↓, Snail↓, p‑SMAD2↓, p‑SMAD3↓, IKKα↑, TumCMig↓, NA↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1↓, CycB↓, cycE↓, cycD1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
914- QC,    Quercetin and Cancer Chemoprevention
- Review, NA, NA
GSH↓, ROS↑, TumCCA↑, Ca+2↑, MMP↓, Casp3↑, Casp8↑, Casp9↑, β-catenin/ZEB1↓, AMPKα↑, ASK1↑, p38↑, TRAIL↑, DR5↑, cFLIP↓, Apoptosis↑,
916- QC,    Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells
- Review, Ovarian, NA
COX2↓, CRP↓, ER Stress↑, Apoptosis↑, GRP78/BiP↑, CHOP↑, p‑STAT3↓, PI3K↓, Akt↓, mTOR↓, cMyc↓, cycD1↓, cFLIP↓, IL6↓, IL10↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   Akt↓,5,   p‑Akt↓,2,   AMPK↑,2,   AMPKα↑,1,   angioG↓,1,   AntiAg↓,1,   Apoptosis↑,6,   ASK1↑,1,   BAX↑,5,   Bcl-2↓,4,   Bcl-xL↓,1,   Bfl-1↓,1,   BID↑,2,   BMPs↑,2,   Ca+2↑,1,   Casp3↓,1,   Casp3↑,7,   Casp8↑,4,   Casp9↑,6,   cl‑Casp9↑,1,   CD133↓,1,   CDK2↓,2,   CDK4↓,1,   CDK6↓,2,   cFLIP↓,15,   chemoP↑,1,   ChemoSen↑,1,   CHOP↑,2,   CLDN2↓,1,   p‑cMET↑,1,   cMyc↓,4,   COX2↓,5,   CRP↓,1,   CXCL12↓,1,   CXCR4↓,2,   cycA1↓,1,   CycB↓,1,   cycD1↓,5,   cycE↓,1,   Cyt‑c↑,4,   Diablo↑,1,   DNMTs↓,1,   DR4∅,1,   DR5↓,1,   DR5↑,7,   E-cadherin↑,1,   ECAR↓,2,   eff↓,2,   eff↑,4,   EGFR↓,2,   eIF2α↑,1,   EMT↓,2,   ER Stress↑,4,   ERK↓,1,   ERK↝,1,   p‑ERK↓,1,   FADD↑,3,   FasL↑,3,   Foxm1↓,1,   GLUT1↓,1,   Glycolysis↓,1,   GRP78/BiP↑,2,   GSH↓,2,   H2O2↑,1,   ac‑H3↑,1,   ac‑H4↑,1,   HATs↓,1,   HDAC↓,2,   Hif1a↓,3,   HO-1↓,1,   IAP1↓,1,   IAP2↓,1,   ICAM-1↓,1,   IKKα↑,1,   IL10↓,3,   IL6↓,3,   iNOS↓,1,   Ki-67↓,1,   lactateProd↓,1,   MAPK↝,1,   MDR1↓,1,   MMP↓,4,   MMP2↓,4,   MMP9↓,3,   MMP9:TIMP1↓,1,   MMPs↓,4,   mTOR↓,5,   p‑mTOR↓,1,   N-cadherin↓,2,   NA↑,1,   Nestin↓,1,   NF-kB↓,3,   NO↓,1,   OCR↓,1,   OCR↑,1,   P-gp↓,1,   P21↑,2,   p27↑,2,   p38↑,1,   P53↑,3,   PARP↑,1,   cl‑PARP↑,2,   PARP1↑,1,   PCNA↓,2,   p‑PERK↑,1,   PI3K↓,4,   PI3k/Akt/mTOR↓,1,   PKCδ↓,1,   PKM2↓,1,   PTEN↑,1,   RAS↓,1,   RAS↑,1,   Rho↑,1,   ROCK1↑,1,   ROS↓,1,   ROS↑,6,   Shh↓,1,   p‑SMAD2↓,1,   p‑SMAD3↓,1,   Snail↓,2,   STAT3↓,4,   p‑STAT3↓,2,   survivin↓,2,   TGF-β↓,1,   TNF-α↓,1,   TRAIL↑,1,   TSP-1↑,1,   TumAuto↑,1,   TumCCA↑,5,   TumCG↓,1,   TumCI↓,1,   TumCMig↓,3,   tumCV↓,2,   TumMeta↓,1,   Twist↓,2,   uPA↓,1,   VEGF↓,4,   VEGFR2↓,1,   Vim↓,1,   Wnt/(β-catenin)↓,1,   XIAP↓,2,   β-catenin/ZEB1↓,2,  
Total Targets: 143

Results for Effect on Normal Cells:
ALAT↓,1,   ALP↓,1,   AntiAg↑,2,   AntiCan↑,1,   antiOx↑,3,   AST↓,1,   Aβ↓,1,   BBB↑,1,   BioAv↓,1,   cardioP↑,3,   Casp3↓,2,   Catalase↑,1,   COX2↓,1,   eff↓,1,   ERK↓,1,   FASN↓,1,   GSH↑,2,   hepatoP↑,1,   HO-1↑,1,   IKKα↑,1,   IL10↓,1,   IL6↓,2,   IL8↓,1,   Inflam↓,3,   IronCh↓,1,   Keap1↑,1,   lipid-P↓,1,   MDA↓,1,   memory↑,1,   NADPH↓,1,   neuroP↑,2,   NF-kB↓,2,   NRF2↑,3,   P-gp↓,1,   PGC-1α↑,1,   PGE2↓,1,   PPARγ↑,1,   p‑Rac1↓,1,   RenoP↑,1,   Rho↓,1,   ROS↓,5,   SIRT3↑,1,   TNF-α↓,1,   toxicity↓,1,  
Total Targets: 44

Scientific Paper Hit Count for: cFLIP, cellular FLICE-like inhibitory protein
5 Quercetin
3 Garcinol
3 Honokiol
2 Baicalein
1 Evodiamine
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:885  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page