Database Query Results : , , SOD2

SOD2, MnSOD: Click to Expand ⟱
Source:
Type: protein
Manganese superoxide dismutase (MnSOD, also known as SOD2).
SOD2 (Superoxide Dismutase 2) is a protein that is a member of the superoxide dismutase family of enzymes, which are involved in the detoxification of superoxide radicals.

-MnSOD is localized in the mitochondria and plays a key role in detoxifying superoxide radicals, thereby limiting oxidative damage and maintaining mitochondrial integrity.
• By modulating ROS levels, MnSOD influences cellular signaling pathways involved in proliferation, apoptosis, and metabolic adaptation—all of which are critical during tumorigenesis.

Typically low SOD2 expression in cancers, with poor prognosis.

-Increased MnSOD levels may help tumor cells manage the high levels of ROS resulting from rapid cell division and metabolic alterations, which can contribute to tumor progression.
- Some prognostic studies associate high levels of MnSOD with resistance to apoptosis and poorer patient outcomes; however, findings are not entirely consistent across all studies.

• Depending on the tumor type and the balance with other antioxidant systems, high MnSOD can be associated with either favorable or unfavorable clinical outcomes, reflecting its dual roles in cancer biology.
Scientific Papers found: Click to Expand⟱
4113- ,    Post-exposure Effects of PEMF on ROS levels in H2O2-treated Glioblastoma Cell Line
- in-vitro, Nor, U87MG
*ROS↓, *SOD2↑,
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
2612- Ba,  MF,    The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
2893- HNK,  doxoR,    Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts
- in-vivo, Nor, NA
*mitResp↑, *PPARγ↑, *cardioP↑, *SIRT3↑, *ROS↓, *GSH↑, *SOD2↑,
2901- HNK,  doxoR,    Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts
- in-vivo, Nor, NA
*mitResp↑, *PPARγ↑, *Inflam↓, *ROS↓, *cardioP↑, *SOD2↑, *LDH↓,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
968- OA,    Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MBT-2
Hif1a↓, SIRT3↑, SOD2↑, GlucoseCon↓, Glycolysis↓, TumCG↓,
2042- PB,    Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury
- in-vitro, Nor, NA
*HDAC↓, *toxicity↓, *LDH↓, *SOD2↑, *ROS↓, *cardioP↑, *antiOx↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB↓, cycD1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, NA↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE↓, *cycD1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3919- PTS,    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *SIRT1∅, *PPARα↑, *SOD2↑, *JNK↓, *p‑tau↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Results for Effect on Cancer/Diseased Cells:
Akt↓,4,   angioG↓,1,   AP-1↓,1,   Apoptosis↑,1,   AR↓,1,   ATF3↑,1,   ATF4↑,2,   Bak↑,1,   BAX↑,4,   Bcl-2↓,3,   Bcl-xL↓,1,   BIM↑,1,   cardioP↑,1,   Casp3↑,4,   cl‑Casp3↑,1,   Casp7↑,1,   Casp8↑,1,   cl‑Casp9↑,1,   Catalase↑,2,   CDC2↓,1,   CDK1↓,2,   CDK2↓,2,   CDK4↓,3,   CDK6↓,1,   cFos↓,1,   chemoP↑,1,   ChemoSen↑,3,   CHK1↓,1,   Chk2↓,1,   CHOP↑,2,   cMET↓,1,   cMyc↓,1,   COX2↓,1,   CSCs↓,1,   cycA1↓,1,   CycB↓,2,   cycD1↓,1,   cycE↓,1,   Cyt‑c↑,3,   Diablo↑,1,   DNMTs↓,1,   Dose?,1,   E-cadherin↑,1,   E6↓,1,   E7↓,1,   ECAR↓,1,   ECM/TCF↓,1,   eff↓,1,   eff↑,3,   eff↝,1,   EGFR↓,1,   p‑eIF2α↑,1,   EMT↓,2,   ER Stress↑,1,   ER-α36↓,1,   ERK↓,1,   p‑ERK↓,1,   FOXO3↑,2,   p‑FOXO3↓,1,   GlucoseCon↓,1,   GlutMet↓,1,   Glycolysis↓,3,   GPx1↓,1,   GPx1↑,1,   GSH↓,1,   GSH↑,1,   GSR↑,1,   H2O2↑,1,   H3↑,1,   HDAC↓,1,   p‑HER2/EBBR2↓,1,   HEY1↓,1,   HGF/c-Met↓,2,   Hif1a↓,2,   HK2↓,1,   HO-1↑,3,   HSP90↓,1,   IGF-1R↓,1,   IKKα↓,1,   IL6↓,1,   IL8↓,1,   JAK1↓,1,   JAK2↓,1,   Ki-67↓,2,   LDHA↓,1,   lipid-P↓,1,   lipid-P↑,1,   MAPK↓,1,   MAPK↑,1,   Mcl-1↓,1,   MDA↑,1,   MDM2↓,1,   mitResp↓,1,   MMP↓,2,   MMP2↓,3,   MMP9↓,5,   MMPs↓,2,   mTOR↓,1,   N-cadherin↓,2,   NA↓,1,   NADPH↑,1,   Nanog↓,1,   NF-kB↓,3,   NOTCH↓,1,   NOX4↓,1,   NQO1↑,2,   NRF2↑,2,   OCR↑,2,   OCT4↓,1,   OS↑,1,   OXPHOS↑,2,   P21↑,2,   p38↑,1,   P53↑,4,   PARP↑,2,   PCNA↓,1,   PDGFR-BB↓,1,   PGC-1α↑,1,   PI3K↓,1,   PKM2↓,1,   PTEN↑,2,   RadioS↑,1,   RB1↓,1,   p‑RB1↓,1,   RenoP↑,1,   ROS↓,1,   ROS↑,4,   selectivity↑,1,   SIRT1↑,1,   SIRT3↑,2,   Slug↓,2,   p‑SMAD2↓,1,   p‑SMAD3↓,1,   SMAD4↓,1,   Snail↓,2,   SOD↑,2,   SOD1↓,1,   SOD1↑,2,   SOD2↓,1,   SOD2↑,7,   SOX2↓,1,   Sp1/3/4↓,2,   STAT3↓,2,   survivin↓,1,   Telomerase↓,1,   TGF-β↓,1,   TIMP1↑,2,   TOP2↓,1,   toxicity↓,2,   TrxR↓,1,   TumCCA↑,1,   TumCD↑,1,   TumCG↓,4,   TumCI↓,1,   TumCMig↓,1,   TumCP↓,4,   tumCV↓,1,   TumMeta↓,2,   TumVol↓,1,   TumW↓,1,   Twist↓,1,   uPA↓,2,   VEGF↓,1,   Vim↓,2,   Warburg↓,1,   β-catenin/ZEB1↓,1,   γH2AX↑,1,  
Total Targets: 167

Results for Effect on Normal Cells:
AChE↓,1,   Akt↑,1,   AntiCan↑,1,   antiOx↑,3,   AP-1↓,1,   BBB↑,1,   BChE↓,1,   BioAv↓,2,   BioAv↑,3,   BioAv↝,1,   Ca+2↓,1,   Ca+2↑,1,   cardioP↑,6,   Cartilage↑,1,   Casp3?,1,   Catalase↑,5,   CDK2↓,1,   CDK4↓,1,   cognitive↑,2,   COX2↓,1,   CREB↑,1,   cycD1↓,1,   cycE↓,1,   Dose↝,3,   E2Fs↑,1,   eff↑,1,   ERK↑,1,   GABA↑,1,   GPx↑,4,   GPx1↑,2,   GPx3↑,1,   GPx4↑,2,   GSH↑,4,   GSR↑,4,   H2O2↓,2,   Half-Life↝,1,   HDAC↓,1,   hepatoP↓,1,   hepatoP↑,2,   HO-1↑,2,   IGF-1↑,1,   IGF-1R↓,1,   IKKα↓,1,   IL1β↓,1,   IL1β↑,1,   IL6↓,2,   IL8↓,1,   Inflam↓,6,   iNOS↓,1,   JAK↓,1,   JNK↓,1,   Keap1↓,1,   LDH↓,2,   lipid-P↓,2,   MDA↓,2,   memory↑,1,   mitResp↑,2,   MMP2↓,1,   MMP9↓,1,   neuroP↑,4,   NF-kB↓,2,   NO↓,1,   NO↑,1,   NRF2↑,3,   other↓,1,   P53↓,1,   Pain↓,2,   PCNA↓,1,   PDGFR-BB↓,1,   PGE2↑,1,   PI3K↑,1,   PPARα↑,1,   PPARγ↑,2,   Prx↑,1,   QoL↑,1,   RB1↓,1,   RNS↓,1,   ROS↓,10,   SIRT1∅,1,   SIRT3↑,1,   SOD↑,4,   SOD1↑,4,   SOD2↑,14,   p‑tau↓,1,   TGF-β↑,1,   TNF-α↓,3,   toxicity↓,2,   toxicity∅,2,   VEGF↓,1,   VEGF↑,1,  
Total Targets: 90

Scientific Paper Hit Count for: SOD2, MnSOD
7 Magnetic Fields
3 Honokiol
2 doxorubicin
2 Pterostilbene
1 5-Aminolevulinic acid
1 Andrographis
1 Ashwagandha
1 Baicalein
1 EGCG (Epigallocatechin Gallate)
1 Magnetic Field Rotating
1 Oroxylin-A
1 Phenylbutyrate
1 Piperlongumine
1 Quercetin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:935  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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