Database Query Results : , , Necroptosis

Necroptosis, Necroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Necroptosis, is a form of programmed cell death that is regulated by the cell's own mechanisms. It is a form of cell death that is mediated by specific signaling pathways, including the RIP1-RIP3-MLKL pathway. Necroptosis is characterized by the activation of specific enzymes, such as RIP1 and RIP3, which lead to the formation of a necroptotic complex that ultimately causes cell death.

Necroptosis expression can be elevated in certain types of cancer, it can also be reduced in other types of cancer.
Scientific Papers found: Click to Expand⟱
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,
1536- Api,    Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
- in-vitro, MM, MSTO-211H - in-vitro, MM, H2452
tumCV↓, ROS↑, MMP↓, ATP↓, Apoptosis↑, Necroptosis↑, DNAdam↑, TumCCA↑, Casp3↑, cl‑PARP↑, MLKL↑, p‑RIP3↑, Bax:Bcl2↑, eff↓, eff↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
988- EMD,    Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS
- in-vitro, RCC, NA
Necroptosis↑, p‑RIP1↑, MLKL↑, ROS↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, NA, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
1992- Part,    Parthenolide induces ROS-dependent cell death in human gastric cancer cell
- in-vitro, BC, MGC803
TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,
2222- SK,    The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis
- in-vitro, OS, U2OS - in-vitro, OS, 143B - in-vivo, NA, NA
Necroptosis↑, RIP1↑, RIP3↑, OS↑, P53↑,
2221- SK,    Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression
- in-vitro, Lung, A549
Apoptosis↑, TumCP↓, tumCV↓, Necroptosis↑, P53↑, ROS↑, NF-kB↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
2184- SK,  Cisplatin,    PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis
- in-vitro, CRC, T24
PKM2↓, ChemoSen↑, Necroptosis↑,
4439- SNP,    Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)
- in-vitro, Cerv, HeLa
ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Results for Effect on Cancer/Diseased Cells:
AIF↑,1,   Akt↓,3,   angioG↓,2,   AntiCan↑,2,   Apoptosis↓,1,   Apoptosis↑,10,   ATF2↓,1,   ATP↓,1,   BAX↑,1,   Bax:Bcl2↑,1,   Bcl-2↓,1,   BIM↑,1,   BioAv↓,1,   Ca+2↓,1,   Ca+2↑,2,   cardioP↑,1,   Casp↑,1,   Casp3↑,3,   proCasp3↑,1,   Casp8↑,1,   Casp9↑,1,   ChemoSen↑,2,   CSCs↓,1,   Cyt‑c↑,2,   DNAdam↑,3,   Dose↝,1,   Dose∅,1,   eff↓,8,   eff↑,3,   EGFR↓,1,   EGR1↑,1,   EMT↓,1,   ERK↓,1,   ERK↑,1,   p‑ERK↓,1,   FAK↓,1,   FOXO3↑,1,   GLUT1↓,1,   Glycolysis↓,1,   GRP58↓,1,   GSH↓,2,   Half-Life↓,1,   p‑JNK↑,1,   Keap1↑,1,   LC3B↑,1,   LDH↝,1,   lipid-P↑,1,   MAPK↑,2,   MLKL↑,4,   p‑MLKL↓,1,   MMP↓,5,   MMPs↓,1,   mTOR↓,1,   Necroptosis↑,15,   NF-kB↓,3,   NO↑,1,   OS↑,1,   p38↑,2,   p‑p38↑,1,   P53↑,2,   p‑P53↑,1,   p62↑,2,   p‑PARP↑,1,   cl‑PARP↑,2,   PI3K↓,3,   PKM2↓,3,   RadioS↑,1,   RIP1↓,2,   RIP1↑,2,   p‑RIP1↑,1,   RIP3↓,1,   RIP3↑,4,   p‑RIP3↑,2,   ROS↑,13,   selectivity↓,1,   selectivity↑,3,   SIRT1↑,1,   Src↓,1,   TrxR1↓,1,   TumAuto↑,2,   TumCCA↑,5,   TumCD↑,1,   TumCG↓,1,   TumCG↑,1,   TumCI↓,1,   TumCMig↓,2,   TumCP↓,3,   tumCV↓,3,   TumW↓,1,   VEGF↓,1,   β-catenin/ZEB1↓,1,  
Total Targets: 91

Results for Effect on Normal Cells:
angioG↑,1,   antiOx↑,1,   ATP↑,1,   BAX↓,1,   Bcl-2↑,1,   BioAv↓,1,   BioAv↑,2,   Ca+2↑,1,   Catalase↑,1,   COX2↓,1,   FAK↑,1,   GPx↑,1,   Half-Life↝,1,   Inflam↓,1,   MPO↓,1,   neuroP↑,1,   NF-kB↑,1,   NRF2↑,1,   other↑,1,   ROS↓,1,   ROS↑,1,   SOD↑,1,   STAT3↑,1,   TNF-α↓,1,   toxicity∅,1,   VEGF↑,1,   Wnt↑,1,   β-catenin/ZEB1↑,1,  
Total Targets: 28

Scientific Paper Hit Count for: Necroptosis, Necroptosis
7 Shikonin
2 Apigenin (mainly Parsley)
1 Amodiaquine
1 Metformin
1 Emodin
1 Magnetic Fields
1 Parthenolide
1 Piperine
1 Cisplatin
1 Silver-NanoParticles
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:944  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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