Database Query Results : , , eff

eff, efficacy: Click to Expand ⟱
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Type:
Power to enhance an anti cancer effect
Scientific Papers found: Click to Expand⟱
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoP↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3824- Aroma,    Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties
- Human, AD, NA
*cognitive↑, *memory↑, *AChE∅, *Mood↑, *eff↝,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP↑, DR5↑, Dose↝, BG↓, DNMTs↓,
2612- Ba,  MF,    effect_of_a_static_magnetic_field_and_baicalin_or_baicalein_interactions_on_amelanotic_melanoma_cell_cultures_C32">The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1↓, cycE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1↓, cycE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
2399- CA,  EA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- Review, Col, NA
eff↝, eff↑, Weight↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
2808- CUR,    Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformation
- in-vitro, Liver, HUH7
Ferritin↓, IronCh↑, TumAuto↑, Apoptosis↑, eff↝, Dose↝,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
2170- dietMet,    Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- Study, Var, NA
OS↑, eff↝, other↝,
2165- dietP,  SFN,    Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
- Trial, PC, NA
Dose↝, OS↑, eff↝,
2151- Ex,    The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis
- Review, Var, NA
eff↑, eff↝,
2173- FA,  VitB12,    Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
- Study, CRC, NA
Risk↓, eff↝, eff↝, homoC↓,
2176- FA,  VitB12,    Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions
- Review, Var, NA
homoC↓, eff↝,
2174- FA,  VitB12,   
- Analysis, Var, NA
homoC↓, eff↑, eff↑, eff↑, eff↝, homoC↝, other?,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
*BioAv↑, *eff↝, BioEnh↑,
1904- GoldNP,  SNP,    Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis
- in-vitro, Lung, H157 - in-vitro, BC, MCF-7 - in-vitro, Colon, HCT15 - in-vitro, Melanoma, A375
TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
2517- H2,    Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
- in-vitro, Var, A549 - in-vitro, NA, HCT116 - in-vitro, NA, HeLa - in-vitro, NA, HepG2 - in-vitro, NA, HT1080 - in-vitro, NA, PC3 - in-vitro, NA, SH-SY5Y
TumCP↓, other↝, eff↝, mt-UPR↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2529- H2,    Guidelines for the selection of hydrogen gas inhalers based on hydrogen explosion accidents
- Analysis, Nor, NA
other↑, eff↝, eff↝, other↝, other↝, other↝, other↝, other↝,
1925- JG,    Redox regulation of mitochondrial functional activity by quinones
- in-vitro, NA, NA
other↓, ROS↑, MMP↓, eff↝,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
2486- metroC,  capec,    Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases
- Case Report, HCC, NA
OS↑, eff↝, Dose↝, AFP↓, Dose↝, TumVol↓, AFP↓,
2487- metroC,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
2240- MF,    Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathway
- in-vitro, Nor, C3H10T1/2
*Ca+2↑, *Diff↑, *BMD↑, *Wnt↑, *β-catenin/ZEB1↑, *eff↝,
2239- MF,    Time-varying magnetic fields increase cytosolic free Ca2+ in HL-60 cells
- in-vitro, AML, HL-60
Ca+2↑, eff↝,
2252- MF,  HPT,    Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins?
- Review, NA, NA
HSPs∅, *HSPs↑, eff↝, *eff↑, eff↑, eff↓,
535- MF,    Electromagnetic Fields Trigger Cell Death in Glioblastoma Cells through Increasing miR-126-5p and Intracellular Ca2+ Levels
- in-vitro, Pca, PC3 - in-vitro, GBM, A172 - in-vitro, Pca, HeLa
Apoptosis↑, miR-129-5p↑, Ca+2↑, eff↝,
534- MF,    Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, Nor, MCF10
Ca+2↑, Apoptosis↑, eff↝, eff↑, selectivity↑, eff↝, eff↝,
532- MF,    A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposure
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
TumCP↓, MMP↓, ROS↑, eff↝, selectivity↑,
3479- MF,    Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro Studies
- Review, NA, NA
*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, NA, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
188- MFrot,  MF,    Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
- in-vitro, GBM, GBM115 - in-vitro, GBM, DIPG
ROS↑, SDH↓, eff↓, RPM↑, eff↓, eff↑, eff↝, eff↝, Casp3↑, eff↝, SOD↓,
226- MFrot,  MF,    Involvement of midkine expression in the inhibitory effects of low-frequency magnetic fields on cancer cells
- in-vitro, NA, A549 - in-vitro, NA, LoVo
TumCP↓, eff↝,
229- MFrot,  MF,    Molecular mechanism of effect of rotating constant magnetic field on organisms
- in-vivo, Nor, NA
*NO↑, *5HT↓, *eff↝, *eff↝, *β-Endo↑, *other↓,
3841- Moringa,    Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion
- in-vivo, Stroke, NA
*MDA↓, *SOD↑, *neuroP↑, *ROS↓, *Inflam↓, *eff↝,
2049- PB,    Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors
- Review, Var, NA
HDAC↓, ac‑H3↑, ac‑H4↑, ac‑H3↑, eff↝, toxicity↓,
2063- PB,  Rad,    Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation
- in-vitro, GBM, U87MG - NA, NA, U251
RadioS↑, eff↝, P53↝,
2068- PB,    Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism
- in-vivo, Nor, NA
glut↓, NH3↓, eff↝,
2065- PB,  TMZ,    Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells
- in-vitro, GBM, NA
eff↑, ROS↑, MMP↓, ER Stress↑, CHOP↑, GRP78/BiP↑, pro‑Casp12↓, eff↝, Ca+2↝,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
2953- PL,    Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation
- in-vitro, Nor, NA
*ROS↑, *GSTA1↓, eff↝, *toxicity↓, ROS↑, *Hif1a↓,
3611- QC,    Quercetin and vitamin C supplementation: effects on lipid profile and muscle damage in male athletes
- Trial, Nor, NA
*eff↝, *LDH↓,
2442- RES,    High absorption but very low bioavailability of oral resveratrol in humans
- in-vitro, Nor, NA
BioAv↝, Half-Life↝, BioAv↓, eff↝,
3087- RES,    Resveratrol cytotoxicity is energy-dependent
- Review, Var, NA
OXPHOS↓, eff↝, eff↑,
4357- RF,    Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies
- Review, Var, NA
other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,
3034- RosA,  RES,  Ba,    The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells
- in-vitro, BC, MCF-7
DNMTs↓, eff↑, eff↝,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
2140- Se,    Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression
- Review, Var, NA
Risk↓, antiOx↑, eff↑, eff↝,
4464- Se,    Antioxidant Properties of Selenium Nanoparticles Synthesized Using Tea and Herb Water Extracts
- Study, NA, NA
*eff↑, *eff↝,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, *NA↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
1281- SK,    Enhancement of NK cells proliferation and function by Shikonin
- in-vivo, Colon, Caco-2
Perforin↑, GranB↑, p‑ERK↑, p‑Akt↑, NK cell↑, eff↝,
2189- SK,    PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells
- in-vitro, Melanoma, NA
PKM2↓, chemoP↑, eff↝, lactateProd↓, ROS↑, *ROS?, *PKM2↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2835- SNP,  Gluc,    Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake
- in-vitro, Liver, HepG2
Dose↝, eff↑, ROS↑, eff↝, eff↑, eff↝, eff↑, eff↝,
2836- SNP,  Gluc,    Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cells
- in-vitro, Cerv, HeLa
eff↝, TumCCA↑, eff↑, eff↑, ROS↑, GSH↓, SOD↓, lipid-P↑, LDH↑,
4362- SNP,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
4421- SNP,    Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells
- in-vitro, Cerv, NA
selectivity↑, eff↝, other↝,
4554- SNP,    Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects
- in-vitro, Cerv, HeLa
Telomerase↓, eff↝,
4553- SNP,    Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types
- in-vitro, Nor, RAW264.7
*Wound Healing↑, *eff↝, *toxicity↝,
1903- SNP,    Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Managemen
- in-vitro, Lung, U1285
TrxR↓, eff↝, ROS↑,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, eff↑, eff↝,
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX↓, PDK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,
2096- TQ,    Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines
- in-vitro, Nor, GP-293 - in-vitro, Kidney, ACHN
selectivity↑, eff↝,
2104- TQ,    The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, UHRF1↓, DNMT1↓, HDAC1↓, eff↝,
2412- TTT,    A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights
- Review, GBM, NA
TumCG↓, eff↝, OS↑,
4043- VitB12,  FA,    Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
- Trial, AD, NA
*other↑, *other↑, *eff↝, *homoC↓, *cognitive↑,
4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,
3117- VitC,    Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
- in-vitro, Nor, mESC
TET1↑, eff↝,
3139- VitC,    Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
- in-vitro, Nor, H9c2
*Apoptosis∅, *LDH∅, *MDA∅, *SOD↓, eff↝,
2171- VitD3,    Vitamin D and the Immune System
- Analysis, Nor, NA
eff↑, Dose↝, eff↝, eff↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 84

Results for Effect on Cancer/Diseased Cells:
AFP↓,2,   Akt↓,5,   p‑Akt↓,1,   p‑Akt↑,1,   AMPK↑,4,   AMPK↝,1,   angioG↓,6,   angioG↑,1,   AntiCan↑,5,   antiOx↑,3,   AntiTum↑,1,   Apoptosis↑,9,   AR↓,1,   ATF3↑,1,   ATF4↑,1,   ATP↓,2,   i-ATP↓,1,   BAX↑,3,   Bax:Bcl2↑,3,   Bcl-2↓,2,   BG↓,2,   BioAv↓,5,   BioAv↑,1,   BioAv↝,2,   BioEnh↑,2,   CA↓,1,   Ca+2↑,8,   Ca+2↝,2,   CAIX↓,1,   cardioP↑,1,   Casp↑,4,   Casp12↑,1,   pro‑Casp12↓,1,   Casp3↑,5,   cl‑Casp3↑,1,   Casp7↑,1,   Casp8↑,2,   Casp9↑,4,   CCR7↓,1,   CD133↓,1,   CD44↓,2,   CD8+↑,1,   CDC2↓,1,   CDK2↓,2,   CDK4↓,6,   CDK4↑,1,   CDK6↓,2,   CDK6↑,1,   chemoP↑,6,   ChemoSen↑,8,   ChemoSideEff↓,2,   CHOP↑,5,   CK2↓,1,   cMyc↓,2,   CoQ10↑,1,   COX2↓,7,   CSCs↓,5,   CXCR4↓,2,   cycA1↓,1,   CycB↓,1,   cycD1↓,5,   CycD3↓,1,   cycE↓,3,   Cyt‑c↑,7,   Diablo↑,1,   Diff↓,1,   DNAdam↑,4,   DNMT1↓,1,   DNMTs↓,2,   Dose?,3,   Dose↓,1,   Dose↑,3,   Dose↝,12,   Dose∅,2,   DR5↑,3,   E-cadherin↓,1,   E-cadherin↑,5,   ECAR↓,1,   eff↓,4,   eff↑,44,   eff↝,77,   EGF↓,1,   EGFR↓,3,   eIF2α↑,1,   EMT↓,5,   ER Stress↑,3,   ERK↓,3,   ERK↑,1,   p‑ERK↑,1,   FAK↓,2,   Fas↑,2,   Ferritin↓,2,   Ferroptosis↑,1,   FOXO3↑,1,   Gli↓,1,   glut↓,1,   GLUT1↓,3,   Glycolysis↓,4,   GPx1↓,1,   GPx1↑,1,   GPx4↓,2,   GranB↑,1,   GRP78/BiP↓,1,   GRP78/BiP↑,2,   GSDMD↑,1,   GSH↓,2,   GSH↑,1,   GSK‐3β↓,1,   GSTs↑,1,   GutMicro↑,2,   ac‑H3↑,2,   ac‑H4↑,1,   Half-Life↓,2,   Half-Life↝,3,   HATs↑,1,   HDAC↓,3,   HDAC1↓,2,   HDAC3↓,1,   hepatoP↑,1,   HER2/EBBR2↓,1,   Hif1a↓,8,   HO-1↑,2,   homoC↓,4,   homoC↝,1,   HSP70/HSPA5↓,1,   HSP70/HSPA5↑,1,   HSP90↓,1,   HSPs∅,1,   IGF-1↓,3,   IGF-1↑,1,   IGFBP3↑,1,   IKKα↓,1,   IKKα↑,1,   IL1↓,1,   IL12↓,1,   IL1β↓,1,   IL1β↑,1,   IL6↓,3,   IL8↓,2,   Inflam↓,3,   iNOS↓,1,   Insulin↓,1,   IRE1↑,2,   IronCh↑,1,   JAK2↓,1,   p‑JAK2↓,1,   JNK↑,1,   Ki-67↓,2,   lactateProd↓,2,   e-lactateProd↓,1,   LC3II↑,3,   LDH↓,1,   LDH↑,1,   LDHA↓,1,   lipid-P↑,1,   MAPK↓,1,   MAPK↑,1,   MCP1↓,1,   MEK↓,1,   miR-129-5p↑,1,   miR-203↑,1,   MMP↓,10,   MMP2↓,7,   MMP9↓,7,   MMPs↓,2,   MPO↓,1,   mTOR↓,3,   mTOR↝,1,   p‑mTORC1↓,1,   N-cadherin↓,1,   n-MYC↓,1,   NADPH↓,2,   NADPH↑,1,   NDRG1↑,1,   Nestin↓,1,   neuroP↑,1,   NF-kB↓,6,   NF-kB↑,1,   NH3↓,1,   NHE1↓,1,   NK cell↑,1,   NLRP3↑,1,   NOTCH↓,2,   NOXA↑,1,   NRF2↓,2,   OS↑,7,   other?,1,   other↓,2,   other↑,3,   other↝,11,   OXPHOS↓,1,   OXPHOS↑,1,   mt-OXPHOS↑,1,   P-gp↓,1,   p16↑,1,   P21↑,2,   p27↑,3,   p38↑,2,   p50↓,1,   P53↑,4,   P53↝,1,   p62↓,3,   cl‑PARP↑,2,   PD-L1↓,1,   PDGF↓,1,   PDK1↓,1,   PDT+↓,1,   Perforin↑,1,   PERK↑,2,   PGC-1α↑,1,   PGE2↓,4,   PI3K↓,4,   PI3K↑,1,   PKM2↓,2,   PSA↓,1,   PTEN↑,1,   PUMA↑,1,   QoL∅,1,   radioP↑,2,   RadioS↑,5,   Raf↓,1,   RB1↑,1,   Risk↓,3,   ROS?,1,   ROS↓,1,   ROS↑,25,   ROS⇅,1,   RPM↑,1,   p‑RSK↑,1,   p‑S6K↓,1,   SDH↓,1,   selectivity↑,15,   SIRT1↓,1,   SIRT1↑,1,   Snail↓,1,   SOD↓,3,   SOD↑,2,   SOD1↓,1,   SOD1↑,1,   SOD2↓,1,   SOD2↑,1,   sonoP↑,1,   SOX2↓,1,   SREBP1↓,1,   STAT3↓,5,   p‑STAT3↓,1,   survivin↓,2,   Telomerase↓,6,   TET1↑,1,   TGF-β↓,1,   TLR4↓,1,   TNF-α↓,2,   toxicity↓,4,   toxicity↑,1,   toxicity↝,2,   toxicity∅,1,   TRAIL↑,1,   TrxR↓,2,   TrxR1↓,1,   TSP-1↑,2,   TumAuto↑,3,   TumCCA↓,1,   TumCCA↑,8,   TumCG↓,6,   TumCI↓,1,   TumCMig↓,3,   TumCP↓,6,   tumCV↓,1,   TumMeta↓,1,   TumVol↓,1,   TumW↓,1,   Twist↓,2,   UHRF1↓,1,   uPA↓,4,   uPAR↓,1,   mt-UPR↑,1,   VCAM-1↓,1,   VEGF↓,11,   VEGFR2↓,1,   Vim↓,3,   Warburg↓,1,   Weight↑,1,   Wnt↓,3,   XIAP↓,2,   Zeb1↓,2,   β-catenin/ZEB1↓,6,  
Total Targets: 286

Results for Effect on Normal Cells:
5HT↓,1,   AChE∅,1,   adiP↓,1,   ALAT↓,1,   antiOx↓,1,   antiOx↑,3,   mt-antiOx↑,1,   Apoptosis↓,1,   Apoptosis∅,1,   ASK1↓,1,   AST↓,1,   ATP↑,1,   Bax:Bcl2↓,1,   BBB↑,1,   BioAv↓,2,   BioAv↑,1,   BMD↑,1,   BOLD↑,1,   Ca+2↑,2,   cardioP↑,3,   cl‑Casp8↑,1,   Catalase↑,2,   chemoP↑,2,   cognitive↑,6,   CRP↓,2,   Diff↑,1,   DNArepair↑,1,   Dose↝,1,   E2Fs↑,1,   ECAR↓,1,   ECAR↑,1,   eff↓,5,   eff↑,3,   eff↝,16,   EMT↑,1,   GABA↑,1,   GlucoseCon↑,1,   Glycolysis↓,1,   GPx↑,1,   GSH↑,2,   GSTA1↓,1,   GutMicro↑,2,   Half-Life↓,1,   Half-Life↑,1,   HDL↑,1,   hepatoP↑,1,   HEY1↑,1,   Hif1a↓,1,   Hif1a↑,1,   HMGB1↓,1,   HO-1↑,3,   homoC↓,1,   HSPs↑,1,   IL1β↓,1,   IL6↓,1,   IL8↓,1,   Inflam?,1,   Inflam↓,8,   iNOS↓,1,   LDH↓,1,   LDH∅,1,   LDL↓,1,   lipid-P↓,1,   MAPK↑,1,   MDA↓,3,   MDA∅,1,   memory↑,4,   MMP2↑,1,   MMP9↑,1,   Mood↑,1,   MPO↑,1,   mTOR↓,1,   NA↓,1,   NADPH↓,1,   neuroP↑,4,   NO↓,1,   NO↑,1,   NOTCH↑,1,   NRF2↑,3,   OCR↑,1,   mt-OCR↑,1,   other↓,1,   other↑,8,   OXPHOS↑,1,   p38↑,1,   PKM2↓,1,   Prx↑,1,   radioP↑,1,   RenoP↑,1,   Risk↓,3,   Risk↑,1,   ROS?,1,   ROS↓,4,   ROS↑,1,   mt-ROS↑,1,   selectivity↑,1,   Sepsis↓,1,   SIRT1↑,1,   SOD↓,1,   SOD↑,5,   TIMP1↓,1,   TIMP1↑,1,   TNF-α↓,1,   toxicity↓,2,   toxicity↝,1,   toxicity∅,2,   Trx↑,1,   VEGF↑,1,   VitC↑,1,   Wnt↑,1,   Wound Healing↑,1,   β-catenin/ZEB1↑,1,   β-Endo↑,1,  
Total Targets: 113

Scientific Paper Hit Count for: eff, efficacy
13 Magnetic Fields
8 Silver-NanoParticles
5 Vitamin B12
5 Folic Acid
5 Hydrogen Gas
4 Phenylbutyrate
4 Thymoquinone
3 Apigenin (mainly Parsley)
3 Magnetic Field Rotating
3 Resveratrol
3 Shikonin
2 Chemotherapy
2 Baicalein
2 Berberine
2 Caffeic acid
2 Propolis -bee glue
2 diet FMD Fasting Mimicking Diet
2 Sulforaphane (mainly Broccoli)
2 Quercetin
2 metronomic chemo
2 Selenium
2 Glucose
2 Vitamin C (Ascorbic Acid)
1 5-Aminolevulinic acid
1 Anthocyanins
1 Aromatherapy
1 Artemisinin
1 Ashwagandha
1 Ellagic acid
1 Curcumin
1 diet Methionine-Restricted Diet
1 diet Plant based
1 Exercise
1 Fenbendazole
1 flavonoids
1 Kaempferol
1 MCToil
1 Gold NanoParticles
1 Juglone
1 Methylene blue
1 capecitabine
1 Hyperthermia
1 Moringa oleifera
1 Radiotherapy/Radiation
1 temozolomide
1 Piperlongumine
1 Radio Frequency
1 Rosmarinic acid
1 SonoDynamic Therapy UltraSound
1 Silymarin (Milk Thistle) silibinin
1 Taurine
1 Tumor Treating Fields
1 Vitamin B6,pyridoxine
1 Vitamin D3
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:961  State#:0  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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