Database Query Results : , , FOXO3

FOXO3, Forkhead Box O3: Click to Expand ⟱
Source:
Type:
FOXO3 (Forkhead Box O3) is a transcription factor that plays a critical role in regulating apoptosis, cell cycle arrest, DNA repair, and cellular stress responses.

• Positive Prognostic Marker
– In several cancers, higher nuclear FOXO3 expression (denoting active, transcriptionally functional FOXO3) is generally associated with a more favorable prognosis.
– Active FOXO3 can promote cell cycle arrest and apoptosis, thereby inhibiting tumor progression.

• Negative Prognostic Implications
– Conversely, reduced or cytoplasmically sequestered FOXO3 (often due to hyperactivation of the PI3K/Akt signaling pathway) has been linked to aggressive disease and poorer survival
 – Loss of FOXO3 function can allow tumor cells to proliferate unchecked and resist apoptosis, which contributes to a worse outcome.
Scientific Papers found: Click to Expand⟱
4638- HT,    Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation
- in-vitro, CRC, DLD1 - NA, NA, 1-
selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2↓, eff↑, Bax:Bcl2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   HO-1↑, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↑, 5,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   HK2↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 3,   BAD↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-xL↓, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp6↑, 1,   cl‑Casp8↑, 2,   Casp9↑, 1,   Cyt‑c↑, 2,   JNK↑, 1,   p27↑, 2,   PUMA↑, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   PERK↑, 1,   UPR↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   FOXO3↓, 5,   GSK‐3β↓, 2,   HDAC↓, 1,   IGF-1↓, 1,   P70S6K↓, 1,   PTEN↑, 2,   p‑PTEN↓, 1,   STAT3↓, 1,  

Migration ⓘ

Ca+2↑, 1,   i-Ca+2↑, 1,   CLDN2↓, 1,   p‑FAK↑, 1,   MMP7↓, 2,   MMP9↓, 2,   MMPs↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   uPA↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   Hif1a↓, 2,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL10↑, 2,   IL2↑, 1,   IL4↑, 1,   IL6↓, 1,   NF-kB↓, 4,   PGE2↓, 1,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose?, 1,   eff↑, 6,   eff∅, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   IL6↓, 1,   PSA∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   ChemoSideEff↓, 1,   OS↑, 1,   QoL↑, 1,  
Total Targets: 101

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Migration ⓘ

AntiAg↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: FOXO3, Forkhead Box O3
2 Propolis -bee glue
1 HydroxyTyrosol
1 Lycopene
1 Magnolol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:997  State#:0  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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