Database Query Results : , , FOXO3

FOXO3, Forkhead Box O3: Click to Expand ⟱
Source:
Type:
FOXO3 (Forkhead Box O3) is a transcription factor that plays a critical role in regulating apoptosis, cell cycle arrest, DNA repair, and cellular stress responses.

• Positive Prognostic Marker
– In several cancers, higher nuclear FOXO3 expression (denoting active, transcriptionally functional FOXO3) is generally associated with a more favorable prognosis.
– Active FOXO3 can promote cell cycle arrest and apoptosis, thereby inhibiting tumor progression.

• Negative Prognostic Implications
– Conversely, reduced or cytoplasmically sequestered FOXO3 (often due to hyperactivation of the PI3K/Akt signaling pathway) has been linked to aggressive disease and poorer survival
 – Loss of FOXO3 function can allow tumor cells to proliferate unchecked and resist apoptosis, which contributes to a worse outcome.
Scientific Papers found: Click to Expand⟱
3433- ALA,    Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
*ROS↓, *Apoptosis↓, *Hif1a↑, *FOXO1↑, *FOXO3↑, *ATM↑, *SIRT1↑, *SIRT3↑, *CD34↑,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoP↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoP↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
2702- BBR,    The enhancement of combination of berberine and metformin in inhibition of DNMT1 gene expression through interplay of SP1 and PDPK1
- in-vitro, Lung, A549 - in-vitro, Lung, H1975
TumCG↓, MAPK↓, FOXO3↑, TumCCA↑, TumCMig↓, TumCI↓, Sp1/3/4↓, PDK1↓, DNMT1↓, eff↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoP↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
3372- QC,  FIS,  KaempF,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Results for Effect on Cancer/Diseased Cells:
ACLY↓,1,   Akt↓,6,   AMPK↑,1,   angioG↓,4,   AntiCan↑,2,   AP-1↓,1,   Apoptosis↑,3,   ATF3↑,1,   ATF4↑,1,   Bak↑,1,   BAX↑,1,   Bax:Bcl2↑,2,   Bcl-2↓,3,   Bcl-xL↓,1,   BIM↑,1,   BioAv↓,1,   BioEnh↑,1,   Ca+2↓,1,   Ca+2↑,2,   Casp12↑,1,   Casp3↑,3,   cl‑Casp3↑,1,   proCasp3↑,1,   Casp9↑,2,   cl‑Casp9↑,1,   Catalase↓,2,   CDC2↓,1,   CDK1↓,1,   CDK2↓,2,   CDK4↓,3,   CDK6↓,1,   chemoP↑,2,   ChemoSen↑,1,   CHK1↓,1,   Chk2↓,1,   CHOP↑,1,   cJun↓,1,   CK2↓,2,   cMyc↓,1,   COX2↓,4,   CSCs↓,4,   cycA1↓,1,   CycB↓,1,   cycD1↓,1,   CycD3↓,1,   cycE↓,1,   Cyt‑c↑,4,   DNMT1↓,1,   Dose∅,1,   DR4↑,1,   DR5↑,1,   E-cadherin↑,1,   E6↓,1,   E7↓,1,   ECM/TCF↓,1,   eff↓,2,   eff↑,15,   eff↝,1,   EGFR↓,1,   EGR1↑,1,   EMT↓,4,   Endon↑,1,   ER Stress↑,1,   ER-α36↓,1,   ERK↓,3,   p‑ERK↓,1,   FAK↓,3,   FASN↓,1,   FOXO3↑,10,   Gli↓,1,   GLUT1↓,1,   GPx↓,1,   GSH↓,2,   p‑GSK‐3β↓,1,   GSR↑,1,   H3↑,1,   Half-Life↓,1,   HDAC↓,2,   HDAC1↓,1,   HDAC3↓,1,   HER2/EBBR2↓,1,   HEY1↓,1,   Hif1a↓,2,   HO-1↑,2,   HSP90↓,3,   HSPs↓,1,   IGF-1↓,1,   IL6↓,2,   IL8↓,1,   iNOS↓,1,   JNK↓,1,   JNK↑,2,   LDH↓,1,   LDHA↓,1,   lipid-P↑,1,   MAPK↓,1,   MAPK↑,1,   Mcl-1↓,2,   MEK↓,2,   mitResp↓,1,   MMP↓,6,   MMP↑,1,   MMP-10↓,1,   MMP2↓,5,   MMP7↓,1,   MMP9↓,5,   MMPs↓,2,   mTOR↓,1,   N-cadherin↓,2,   NADPH↑,3,   Nanog↓,1,   Necroptosis↑,1,   neuroP↑,1,   NF-kB↓,7,   NOTCH↓,1,   NOTCH3↓,1,   NOX4↓,1,   NOXA↑,1,   NQO1↑,2,   NRF2↓,2,   NRF2↑,2,   OCT4↓,1,   other↓,1,   OXPHOS↓,1,   P21↑,1,   p27↑,1,   p38↓,1,   p38↑,3,   P53↑,1,   p65↓,1,   PARP↑,1,   cl‑PARP↑,1,   PCNA↓,1,   PDGFR-BB↓,1,   PDK1↓,1,   PI3K↓,6,   RadioS↑,1,   RAS↓,1,   p‑RB1↓,1,   RenoP↑,1,   RIP1↑,1,   RIP3↑,1,   ROCK1↑,1,   ROS↓,2,   ROS↑,9,   SIRT1↓,1,   SIRT1↑,2,   SIRT3↓,1,   SIRT3↑,1,   SIRT6↓,1,   Slug↓,1,   p‑SMAD2↓,1,   p‑SMAD3↓,1,   SMAD4↓,1,   Snail↓,1,   SOD↓,2,   SOD2↑,1,   Sp1/3/4↓,1,   STAT3↓,4,   p‑STAT3↓,1,   survivin↓,1,   Telomerase↓,2,   TGF-β↓,1,   TumCCA↓,1,   TumCCA↑,5,   TumCD↑,1,   TumCG↓,4,   TumCI↓,1,   TumCMig↓,2,   TumCP↓,1,   Twist↓,1,   uPA↓,3,   VEGF↓,4,   Vim↓,1,   XIAP↓,1,   β-catenin/ZEB1↓,3,   γH2AX↑,1,  
Total Targets: 177

Results for Effect on Normal Cells:
Akt↓,1,   AMPK↑,4,   AntiAg↑,1,   antiOx↑,5,   Apoptosis↓,1,   APP↓,1,   ATM↑,1,   ATP↑,1,   Aβ↓,2,   BACE↓,1,   BBB↑,1,   BDNF↑,3,   BioAv↝,1,   BP∅,1,   cardioP↑,2,   Casp3?,1,   Catalase↑,2,   CD34↑,1,   chemoP↑,1,   cognitive↑,3,   Dose↑,1,   ER(estro)↓,1,   ER(estro)↑,1,   FOXO1↑,1,   FOXO3↑,5,   GPx1↑,1,   Half-Life↝,2,   Hif1a↑,1,   HO-1↑,1,   IL18↓,1,   IL1β↓,3,   IL6↓,2,   IL8↓,1,   Inflam↓,5,   JNK↓,1,   LDL↓,1,   lipid-P↓,1,   MDA↓,2,   memory↑,3,   mtDam↓,1,   mTOR↓,1,   NADPH↓,1,   neuroP↑,2,   NLRP3↓,4,   NO↓,2,   NRF2↑,2,   other↓,1,   p‑p38↓,1,   p‑PPARγ↓,1,   Prx↑,1,   PTEN↓,1,   ROS↓,5,   mt-ROS↓,1,   Sepsis↓,1,   SIRT1↑,4,   SIRT3↑,2,   SOD1↑,1,   SOD2↑,1,   TLR4↓,1,   TNF-α↓,2,   toxicity↓,2,  
Total Targets: 61

Scientific Paper Hit Count for: FOXO3, Forkhead Box O3
4 Hydrogen Gas
2 Apigenin (mainly Parsley)
2 Ashwagandha
1 Alpha-Lipoic-Acid
1 Andrographis
1 Berberine
1 Capsaicin
1 Quercetin
1 Fisetin
1 Kaempferol
1 Sulforaphane (mainly Broccoli)
1 Shikonin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:997  State#:0  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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