condition found tbRes List
Warburg, Warburg Effect: Click to Expand ⟱
Source:
Type: effect
The Warburg effect is a metabolic phenomenon in which cancer cells preferentially use glycolysis for energy production, even in the presence of oxygen. Targeting the pathways involved in the Warburg effect is a promising strategy for cancer treatment.
The Warburg effect is always accompanied by a hypoxic condition, and activation of HIF-1a contributes to the Warburg effect through coordinated upregulation of glycolysis and downregulation of oxidative phosphorylation.
Warburg effect (GLUT1, LDHA, HK2, and PKM2).
Here are some of the key pathways and potential targets:

Note: use database Filter to find inhibitors: Ex pick target HIF1α, and effect direction ↓

1.Glycolysis Inhibitors:(2-DG, 3-BP)
-HK2 Inhibitors: such as 2-deoxyglucose, can reduce glycolysis
-PFK1 Inhibitors: such as PFK-158, can reduce glycolysis
-PFKFB Inhibitors:
-PKM2 Inhibitors: (Shikonin)
-Can reduce glycolysis
-LDH Inhibitors: (Gossypol, FX11)
-Reducing the conversion of pyruvate to lactate.
-Inhibiting the production of ATP and NADH.
-GLUT1 Inhibitors: (phloretin, WZB117)
-A key transporter involved in glucose uptake.
-GLUT3 Inhibitors:
-PDK1 Inhibitors: (dichloroacetate)
- A key enzyme involved in the regulation of glycolysis.

2.Gluconeogenesis pathway:
-FBP1 Activators: can increase gluconeogenesis
-PEPCK1 Inhibitors: can reduce gluconeogenesis

3.Pentose phosphate pathway:
-G6PD Inhibitors: can reduce the pentose phosphate pathway

4.Mitochondrial metabolism:
-MPC1 Inhibitors: can reduce mitochondrial metabolism and inhibit cancer
-SDH Inhibitors: can reduce mitochondrial metabolism and inhibit cancer cell growth.

5.Hypoxia-inducible factor 1 alpha (HIF1α) pathway:
-HIF1α inhibitors: (PX-478,Shikonin)
-Reduce expression of glycolytic genes and inhibit cancer cell growth.

6.AMP-activated protein kinase (AMPK) pathway:
-AMPK activators: (metformin,AICAR,berberine)
-Can increase AMPK activity and inhibit cancer cell growth.

7.mTOR pathway:
-mTOR inhibitors:(rapamycin,everolimus)
-Can reduce mTOR activity and inhibit cancer cell growth.
Scientific Papers found: Click to Expand⟱
3453- 5-ALA,    The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis
- in-vitro, Lung, A549
OXPHOS↑, OCR↑, Warburg↓, ROS↑, SOD2↑, Catalase↑, HO-1↑, Casp3↑, Apoptosis↑,
2321- ART/DHA,    Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706
Pyro↑, PKM2↓, Casp8↑, Casp3↑, Warburg↓, TumCCA↑, Apoptosis↑,
2388- Ash,    Withaferin A decreases glycolytic reprogramming in breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-453
GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, GLUT1↓, HK2↓, PKM2↓, cMyc↓, Warburg↓, cMyc↓,
2707- BBR,    Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
GLUT1↓, Akt↓, mTOR↓, ATP↓, GlucoseCon↓, TumCP↓, Warburg↓, selectivity↑, TumCCA↑, Glycolysis↓,
2710- BBR,    Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells
- in-vitro, Ovarian, SKOV3
Warburg↓, miR-145↑, HK2↓, TET3↑, Glycolysis↓, PKM2↓, GLUT1↓, LDH↓, PFK2↓, PDK1↓,
2347- CAP,    Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
- in-vivo, Nor, NA - in-vitro, Nor, RAW264.7
*PKM2↓, *LDHA↓, *Warburg↓, *COX2↓, *Sepsis↓, *Inflam↓, *ECAR↓, *OCR↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓, NA↓,
2307- CUR,    Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin
- in-vitro, Colon, HT29 - in-vitro, Laryn, FaDu
PKM2↓, Warburg↓, mTOR↓, Hif1a↓, Glycolysis↓,
1884- DCA,  Sal,    Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines
- in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116
eff↑, pH↓, PDKs↓, Warburg↓,
1875- DCA,    Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
- in-vitro, neuroblastoma, NA - in-vivo, NA, NA
selectivity↑, AntiCan↑, TumVol↓, PDKs↓, mt-OXPHOS↑, MMP↓, Glycolysis↓, toxicity↓, Warburg↓, ROS↑, eff↑,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
2352- dietFMD,    Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Warburg↓, mTOR↓, PKM2↓,
649- EGCG,  CUR,  PI,    Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
*BioEnh↑, EGFR↓, HER2/EBBR2↓, IGF-1↓, MAPK↓, ERK↓, RAS↓, Raf↓, NF-kB↓, p‑pRB↓, TumCCA↑, Glycolysis↓, Warburg↓, HK2↓, Pyruv↓,
2313- Flav,    Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
- Review, Var, NA
Warburg↓, antiOx↑, angioG↓, Glycolysis↓, PKM2↓, PKM2:PKM1↓, β-catenin/ZEB1↓, cMyc↓, HK2↓, Akt↓, mTOR↓, GLUT1↓, Hif1a↓,
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1↓, CDK4↓, CycB↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
994- MET,    Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy
- in-vitro, Var, NA
Glycolysis↓, HK2↓, ATP↓, AMPK↑, P53↑, Warburg↓, Apoptosis↑,
2377- MET,    Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
EMT↓, P70S6K↓, mTOR↓, PKM2↓, Warburg↓, AMPK↑,
2245- MF,    Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis
- in-vitro, Nor, NIH-3T3
Warburg↓, Hif1a↓, *Hif1a∅, Glycolysis↓, *lactateProd↓, *ADP:ATP↓, Pyruv↓, ADP:ATP↓, *PPP↓, *mt-ROS↑, *ROS↓, RPM↑, *ECAR↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, Foxm1↓, cycD1↓, CDK4↓, MMP9↓, HDAC2↓,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3036- RosA,    Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT116 - in-vitro, CRC, LS174T
GlucoseCon↓, lactateProd↓, Hif1a↓, Inflam↓, miR-155↓, STAT3↓, Glycolysis↓, IL6↓, Warburg↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
2403- SFN,    Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3 - in-vivo, NA, NA
ECAR↓, HK2↓, PKM2↓, LDHA↓, Glycolysis↓, Warburg↓,
2356- SK,    ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment
- in-vitro, Ovarian, CaOV3 - in-vitro, Ovarian, OV90 - in-vivo, NA, NA
PKM2↓, Glycolysis↓, FASN↓, lactateProd↓, Warburg↓, TumCG↓, VM↓,
2417- SK,    Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H446
TumCP↓, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, PFKFB2↓, Warburg↓, GLUT1∅, LDHA∅, PKM2∅, GLUT3∅, PDH∅,
2185- SK,    Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- in-vitro, Lung, LLC1 - in-vitro, Melanoma, B16-BL6 - in-vivo, NA, NA
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, selectivity↑, Warburg↓, TumVol↓, TumW↓,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,
3145- VitC,    Warburg_effect">Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect
- in-vitro, CRC, HCT116
Warburg↓, TumCG↓, Glycolysis↓, GlucoseCon↓, ATP↓, lactateProd↓, selectivity↑, GLUT1↓, PKM2↓, LDHA↓, mTOR↓,
3141- VitC,    High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer
- in-vitro, CRC, HCT116
Glycolysis↓, eff↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
3137- VitC,    Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose-induced oncogenic effect by downregulating the Warburg effect
- in-vitro, CRC, HCT116
Warburg↓, TumCG↓,
3136- VitC,    Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- in-vitro, Colon, SW48 - in-vitro, Colon, LoVo
ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,
2367- VitD3,    Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia
- in-vivo, AML, NA
FBP1↑, Warburg↓, Glycolysis↓, lactateProd↓,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 47

Results for Effect on Cancer/Diseased Cells:
ACC↓,1,   ACLY↓,1,   ADP:ATP↓,1,   Akt↓,9,   ALAT↓,1,   AminoA↓,1,   AMPK↓,1,   AMPK↑,6,   angioG↓,3,   AntiCan↑,3,   antiOx↑,1,   Apoptosis↑,10,   ASC↑,1,   AST↓,1,   ATG3↑,1,   ATP↓,9,   ATP↑,2,   ATP:AMP↓,1,   BAX↑,2,   Bcl-2↓,3,   Bcl-xL↓,1,   Beclin-1↑,1,   BG↓,2,   BioAv↑,2,   BioAv↝,3,   BioEnh?,1,   BNIP3↑,1,   CAIX↑,1,   Casp1↓,1,   Casp3↑,5,   Casp8↑,1,   Casp9↑,2,   Catalase↑,1,   CD34↓,1,   CD4+↑,2,   CD8+↑,2,   CDK4↓,3,   ChemoSen↑,6,   ChemoSideEff↓,2,   citrate↓,1,   cMyc↓,5,   COX2↓,3,   Cyc↓,1,   CycB↓,1,   cycD1↓,2,   Cyt‑c↑,1,   Cyt‑c↝,1,   DNAdam↑,2,   DNArepair↑,1,   Dose↝,3,   Dose∅,3,   E-cadherin↑,4,   ECAR↓,3,   eff↑,14,   EGFR↓,2,   EMT↓,4,   ER Stress↑,1,   ERK↓,2,   FAK↓,1,   FASN↓,2,   FBP1↑,1,   Foxm1↓,1,   FOXO1↓,1,   FOXP3↓,1,   G6PD↓,1,   GIT1↓,1,   Gli1↓,1,   GlucoseCon↓,12,   GLUT1↓,12,   GLUT1↑,1,   GLUT1∅,1,   GLUT2↓,1,   GLUT3↑,1,   GLUT3∅,1,   GlutaM↓,1,   Glycolysis↓,26,   GPx↑,1,   GRP78/BiP↑,1,   GSH↑,1,   GutMicro↑,2,   H4↑,1,   HDAC↓,2,   HDAC2↓,3,   HER2/EBBR2↓,1,   Hif1a↓,9,   HK2↓,12,   HMGB1↓,1,   HO-1↓,1,   HO-1↑,3,   HSP27↓,1,   ICAM-1↓,1,   IGF-1↓,2,   IGF-1R↓,1,   IL1β↓,2,   IL6↓,5,   IL6↑,1,   IL8↓,1,   Inflam↓,4,   iNOS↓,1,   Insulin↓,1,   JNK↑,2,   Jun↓,1,   Ki-67↓,1,   lactateProd↓,14,   LAMP2↑,1,   LDH↓,3,   LDHA↓,5,   LDHA∅,1,   M1↓,1,   M2 MC↓,1,   MAPK↓,2,   MAPK↑,2,   MARK4↓,2,   MCP1↓,1,   MDM2↓,1,   miR-145↑,1,   miR-155↓,2,   MMP↓,3,   MMP13↓,1,   MMP2↓,2,   MMP7↓,1,   MMP9↓,4,   MMPs↓,2,   mTOR↓,10,   MUC4↓,1,   N-cadherin↓,2,   NA↓,1,   NADPH↓,2,   Nanog↓,1,   necrosis↑,1,   neuroP↑,2,   NF-kB↓,7,   p‑NF-kB↓,1,   NK cell↑,1,   NLRP3↓,1,   NO↓,1,   NOTCH↓,1,   NRF2↑,3,   OCR↑,4,   OCT4↓,1,   OS↑,2,   other↓,1,   OXPHOS↓,1,   OXPHOS↑,3,   mt-OXPHOS↑,2,   P-gp↑,1,   P21↑,1,   p27↑,1,   p38↑,1,   P53↑,3,   p62↑,1,   p‑p65↓,1,   P70S6K↓,1,   PARP↑,1,   cl‑PARP↓,1,   PD-L1↓,1,   PDH↑,2,   PDH∅,1,   PDK1↓,2,   PDKs↓,3,   PFK↓,1,   PFK1↓,3,   PFK2↓,1,   PFKFB2↓,1,   pH↓,1,   PI3K↓,9,   p‑PI3K↑,1,   PKA↓,1,   PKM2↓,18,   PKM2∅,1,   p‑PKM2↓,1,   PKM2:PKM1↓,1,   p‑pRB↓,1,   PTEN↓,1,   PTEN↑,4,   Pyro↑,1,   Pyruv↓,2,   R5P↝,1,   radioP↑,1,   RadioS↑,1,   Raf↓,1,   RANKL↓,1,   RAS↓,1,   ROS↓,3,   ROS↑,10,   ROS⇅,1,   ROS↝,1,   mt-ROS↑,1,   RPM↑,1,   selectivity↑,7,   SIRT1↓,1,   SIRT1↑,2,   SIRT3↑,1,   SOD2↑,1,   SOX2↓,1,   STAT3↓,3,   STAT5↓,1,   survivin↓,2,   T-Cell↑,1,   talin↓,1,   TET3↑,1,   TGF-β↓,1,   TGF-β↑,1,   Th1 response↑,1,   TKT↝,1,   TLR4↓,1,   TNF-α↓,3,   TNF-α↑,1,   toxicity↓,1,   toxicity∅,1,   Treg lymp↓,2,   TumCCA↑,7,   TumCD↑,2,   TumCG↓,8,   TumCG↑,1,   TumCI↓,4,   TumCMig↓,2,   TumCP↓,12,   tumCV↓,1,   TumMeta↓,3,   TumMeta↑,1,   TumVol↓,2,   TumW↓,1,   VEGF↓,3,   Vim↓,2,   VM↓,1,   Warburg↓,46,   Wnt↓,1,   XIAP↓,1,   Zeb1↓,1,   β-catenin/ZEB1↓,2,  
Total Targets: 231

Results for Effect on Normal Cells:
ADP:ATP↓,1,   AMPK↑,1,   AntiAg↑,1,   AntiAge↑,2,   antiOx↑,3,   mt-antiOx↑,1,   ATP↑,1,   Aβ↓,1,   BBB↑,1,   BG↓,1,   BioAv↝,2,   BioEnh↑,1,   cardioP↑,2,   CardioT↓,1,   Catalase↑,3,   cognitive↑,1,   COX2↓,4,   Dose↝,1,   ECAR↓,3,   eff↝,1,   FAO↑,1,   FASN↓,1,   GlucoseCon↑,1,   Glycolysis↓,1,   GPx↑,2,   GSH↑,2,   GSTs↑,1,   GutMicro↑,1,   hepatoP↑,3,   Hif1a∅,1,   HMGB1↓,1,   HO-1↑,1,   IL1β↓,2,   IL6↓,2,   Inflam↓,4,   Iron↓,1,   IronCh↑,1,   p‑JNK↓,1,   lactateProd↓,1,   LDHA↓,1,   lipid-P↓,1,   memory↑,2,   mitResp↑,1,   MMP↓,1,   MMP↑,1,   motorD↓,1,   mTOR↓,1,   neuroP↑,4,   NF-kB↓,1,   NRF2↑,2,   OCR↑,2,   p38↓,1,   P450↑,1,   PGE2↓,1,   PGM1?,1,   PKA↑,1,   PKM2↓,2,   PPP↓,1,   ROS↓,8,   ROS↑,1,   mt-ROS↑,1,   Sepsis↓,2,   SOD↑,3,   TNF-α↓,1,   toxicity↓,1,   VitC↑,1,   VitE↑,1,   Warburg↓,1,  
Total Targets: 68

Scientific Paper Hit Count for: Warburg, Warburg Effect
6 Vitamin C (Ascorbic Acid)
5 Rosmarinic acid
3 Dichloroacetate
3 diet FMD Fasting Mimicking Diet
3 Methylene blue
3 Shikonin
2 Berberine
2 Capsaicin
2 Celastrol
2 Curcumin
2 Chemotherapy
2 Metformin
2 Resveratrol
2 Thymoquinone
2 Vitamin D3
1 5-Aminolevulinic acid
1 Artemisinin
1 Ashwagandha
1 Citric Acid
1 salinomycin
1 EGCG (Epigallocatechin Gallate)
1 Piperine
1 flavonoids
1 Melatonin
1 Magnetic Fields
1 Sulforaphane (mainly Broccoli)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:947  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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