| Features: |
| Metal Iron is a vital trace element that plays essential roles in various physiological processes. Its importance stems from its involvement in oxygen transport, energy production, DNA synthesis, and numerous enzymatic reactions. – Iron is a critical component of hemoglobin in red blood cells, enabling the binding and transport of oxygen from the lungs to tissues. – Iron participates in redox reactions due to its ability to alternate between ferrous (Fe²⁺) and ferric (Fe³⁺) states. Tumor cells often require increased iron to support their rapid proliferation and metabolic demands. – Elevated iron availability can promote DNA synthesis, cell division, and tumor growth. • Promotion of Reactive Oxygen Species (ROS) Formation: – Iron’s redox-active nature, while important for normal cell functions, can also lead to the generation of reactive oxygen species via reactions such as the Fenton reaction: Fe²⁺ + H₂O₂ → Fe³⁺ + •OH + OH⁻ – The hydroxyl radicals (•OH) produced are highly reactive and can cause oxidative damage to cellular components (DNA, proteins, lipids). – This oxidative damage may contribute to genomic instability, mutations, and the progression of cancer. Cancer cells often exhibit increased iron dependency, targeting iron metabolism is a strategy that is being explored for cancer therapy. – Approaches include the use of iron chelators to sequester iron and limit its availability to tumor cells, thereby inhibiting their growth. – Alternatively, therapies may aim to exploit iron’s capacity to generate toxic ROS beyond a threshold that cancer cells can manage, leading to selective cell death. |
| 1762- | MF, | Fe, | Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane |
| - | in-vitro, | RCC, | NA |
| 1737- | MFrot, | Fe, | Feature Matching of Microsecond-Pulsed Magnetic Fields Combined with Fe3O4 Particles for Killing A375 Melanoma Cells |
| - | in-vitro, | MB, | A375 |
| 3292- | SIL, | Fe, | Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study |
| - | in-vitro, | BC, | 4T1 | - | in-vivo, | BC, | 4T1 |
| 629- | VitC, | Cu, | Fe, | The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer |
| - | in-vitro, | NA, | NA |
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