Database Query Results : Juglone, ,

JG, Juglone: Click to Expand ⟱
Features:
Found in roots, leaves, nut-hulls, bark and wood of walnut trees.
Juglone (5-hydroxy-1,4-naphthoquinone)
Juglans nigra refers to the black walnut tree, which is one of the most well-known sources of juglone
-Research has focused on the hulls (the green outer covering of the walnut) because they have the highest concentrations.
-Fresh hulls can contain juglone levels in the range of approximately 1–5% of the dry weight

-Juglone can redox cycle to generate reactive oxygen species (ROS).
-Increasing Bax, decreasing Bcl‑2, caspase activation, and MMP depolarization.
-Modulation of MAPK pathways (including ERK, JNK, and p38)
-May inhibit NF‑κB signaling
-Cause DNA damage or stress that, in turn, leads to p53 pathway activation— Pin1 Inhibition
–Pin1, a peptidyl-prolyl cis/trans isomerase, is frequently overexpressed in cancer.

-ic50 maybe 5-10uM
-For matching 5uM, crude estimate is 5mg consumption of juglone required which might be 1.5 g of black walnut hull material
Scientific Papers found: Click to Expand⟱
974- JG,    Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro
- in-vitro, PC, MIA PaCa-2
"highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >p‑Akt↓, "highlight2" >TumCP↓, "highlight2" >TumCI↓,
1121- JG,    Juglone suppresses epithelial-mesenchymal transition in prostate cancer cells via the protein kinase B/glycogen synthase kinase-3β/Snail signaling pathway
- in-vitro, Pca, LNCaP
"highlight2" >E-cadherin↑, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Snail↓, "highlight2" >GSK‐3β↑,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
"highlight2" >selectivity↑, "highlight2" >LC3I↑, "highlight2" >LC3II↑, "highlight2" >Beclin-1↑, "highlight2" >ROS↑, "highlight2" >tumCV↓, "highlight2" >Dose↝, "highlight2" >TumAuto↑,
1918- JG,    ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro
- in-vitro, Liver, HepG2 - in-vivo, NA, NA
"highlight2" >TumCG↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >TumAuto↑, "highlight2" >AMPK↑, "highlight2" >mTOR↑, "highlight2" >P53↑, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >toxicity↝, "highlight2" >p62↓, "highlight2" >DR5↑, "highlight2" >Casp8↑, "highlight2" >PARP↑, "highlight2" >cl‑Casp3↑,
1919- JG,    The Anti-Glioma Effect of Juglone Derivatives through ROS Generation
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
"highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >eff↓,
1920- JG,  TQ,  Plum,    Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line
- in-vitro, PC, PANC1
"highlight2" >ROS↑, "highlight2" >TumCMig↓, "highlight2" >MMP9↓,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
"highlight2" >TumCG↓, "highlight2" >Ferroptosis↑, "highlight2" >ROS↑, "highlight2" >Iron↑, "highlight2" >lipid-P↑, "highlight2" >MDA↑, "highlight2" >GSH↓, "highlight2" >FOSL1↑, "highlight2" >HO-1↑,
1922- JG,    Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma
- in-vitro, GBM, U87MG
"highlight2" >tumCV↓, "highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >p‑p38↑, "highlight2" >eff↓, "highlight2" >Apoptosis↑, "highlight2" >OS↑,
1923- JG,    Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
- in-vitro, Endo, NA
"highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >cycA1/CCNA1↓, "highlight2" >ROS↑, "highlight2" >P21↑, "highlight2" >CDK2↓, "highlight2" >CDK1↓, "highlight2" >CDC25↓, "highlight2" >Bcl-2↓, "highlight2" >Bcl-xL↓, "highlight2" >BAX↑, "highlight2" >BAD↑, "highlight2" >Cyt‑c↑,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >BAX↑, "highlight2" >Cyt‑c↑, "highlight2" >ROS↑, "highlight2" >MDA↑, "highlight2" >GPx4↓, "highlight2" >SOD↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >eff↓,
1925- JG,    Redox regulation of mitochondrial functional activity by quinones
- in-vitro, NA, NA
"highlight2" >other↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >eff↝,
1926- JG,    Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway
- in-vitro, BC, MCF-7
"highlight2" >TumCG↓, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >i-Ca+2↑, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3?,
1927- JG,    Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway
- in-vitro, GC, SGC-7901
"highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >Bcl-2↓, "highlight2" >BAX↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3?, "highlight2" >Bax:Bcl2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 2,   ROS↑, 11,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 5,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp3?, 2,   cl‑Casp3↑, 2,   Casp8↑, 1,   Cyt‑c↑, 4,   DR5↑, 1,   Ferroptosis↑, 1,   p‑p38↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3I↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

FOSL1↑, 1,   GSK‐3β↑, 1,   mTOR↑, 1,   PI3K↓, 1,   TumCG↓, 3,  

Migration ⓘ

i-Ca+2↑, 1,   E-cadherin↑, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 4,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↓, 4,   eff↝, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,   toxicity↝, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:105  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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