Oroxylin-A Cancer Research Results

OA, Oroxylin-A: Click to Expand ⟱
Features:
O-methylated flavone, a chemical compound that can be found in the medicinal plants Scutellaria baicalensis [1] and Scutellaria lateriflora, [2] [3] and the Oroxylum indicum tree. [4]
Scientific Papers found: Click to Expand⟱
968- OA,    Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MBT-2
Hif1a↓, SIRT3↑, SOD2↑, GlucoseCon↓, Glycolysis↓, TumCG↓,
991- OA,    Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
- in-vivo, NA, NA - in-vivo, Nor, NA
*Glycolysis↓, *GlucoseCon↓, *lactateProd↓, *ECAR↓, *HK2↓, *PFK↓, *PKM2↓, *LDHA↓,
1130- OA,    Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓,
1229- OA,    Review of the Clinical Effect of Orlistat
- Review, Var, NA
NPC1L1↓, FASN↓, ER Stress↑, angioG↓, TumCG↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   NPC1L1↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  
Total Targets: 8

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:129  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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